DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AgaP_AGAP000214

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_310920.4	Gene:	AgaP_AGAP000214 / 4576149	VectorBaseID:	AGAP000214	Length:	754	Species:	Anopheles gambiae

Alignment Length:	730	Identity:	136/730 - (18%)
Similarity:	244/730 - (33%)	Gaps:	202/730 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 NYRITELVSLDLAYNDLKQLDQFP----EGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVS 238
            ||.:..||..:...|..:|:.:..    ||...:|  |:..:::.      :.:..|.::.||:.
Mosquito     5 NYALELLVLKNFGLNIWEQIKKKAQVNMEGQFLVR--QIYEDDIT------YNLIEAAVDILNIP 61

  Fly   239 CNKL-----STLPRYEQNN-------------HAALVNLSLAGNHLNDSIFEPLHNAAKLR---- 281
            ...:     .|...:.|::             ...|.||....:||  ....|...|...|
Mosquito    62 AGDILELFGKTFFEFCQDSGYDKILQVLGATPRDFLQNLDALHDHL--GTLYPGMRAPSFRCTET 124

  Fly   282 ----VLHLAYNR-------IGVLPAACVR-NWPELEILVL--SGNMLQQLPEEVATLGQLRVLRC 332
                |||....|       ||::.|...: :..::||.::  .|:.::  ||......:..|...
Mosquito   125 NGQLVLHYYSERPGLEHIVIGIVKAVASKLHGVDVEIKIIRRKGDPVE--PEAKKATAEPPVANT 187

  Fly   333 CNNLLLCT-------PQLAKLAMLKVLDLSHNHLDRVNLL-ALVPSRNLKYLDLSGNLQLQVDEQ 389
            .......|       |::.|...:..||.:...|..:.|. .::.|:.  |.....|..|:
Mosquito   188 ATAAAAATPKARHSIPEVVKSVPITSLDPAVPELANLGLCKRILASKT--YATSKSNSALK---- 246

  Fly   390 QFKVCQSQSQRHWSLVDVSG--NNRAALPTT-KIRQVSAQRNQN-------KTSGP------WTM 438
              :...:.:..|.:.:.:|.  |...::|.. ::.:.|...|.|       .:.||      |..
Mosquito   247 --QPTDTSASSHGNKLSISSSQNGSNSIPLCGEVSKASKDTNTNCDSSSSSSSGGPARNGPEWQQ 309

  Fly   439 GFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDS 503
            ...:.||:....:...:|.......|....          ..|:.::....|..|:.:|.|:...
Mosquito   310 KGPKGPGTTAVERSDHFQFLITEISGPKTP----------TRRSDEKDQQAVCQLVAKEPMISPM 364

  Fly   504 AVRDYMKFTLLAAQQ----QCGSVRSAALFHLTRTRAP-----SKVRP--LKSKRYVLRMASTGG 557
            .......|.|:..:.    |.|...|..:..:.....|     ..|||  ..|...:|...:|
Mosquito   365 TFCKIFPFHLMFDRNMHIVQAGRSVSRVIPRIYEKNCPLLALFEAVRPHLQLSFENILAHINT-- 427

  Fly   558 LDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLW----SVMDIDRA 618
              .|:::       ||..|:.|.:.:         |.|.....|:...:..|:    |||::|..
Mosquito   428 --IYVLK-------TKAGVMSKSERY---------LRLKGQMMYIPGSDLILFQCYPSVMNLDDL 474

  Fly   619 ARE-IRKEENSLLAAKR-LVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVR---KKPQ 678
            .:: :...:..|..|.| ||.:::.|.|...|:          |:::.|...|:|:.|   .:.|
Mosquito   475 TKKGLHISDIPLHDASRDLVLLSEKFEAEYKLT----------TNLEILTDRLQQTYRDLESEKQ 529

  Fly   679 PVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPS-----------GQSDRDLLAKDKDD 732
            .....|.  ||..:|.   :|..||    |.|:|.:...|           ||    ..|.:.|.
Mosquito   530 KTDRLLY--SVLPKTV---ANELRH----QRPVAPKRYDSVTLMFSGIVGFGQ----YCAANTDP 581

  Fly   733 EFVLAHARVLQEEQQLEMLDE-TESVSESVLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQ 796
            |..:...::|.|  ...:.|| |:|.|.|                               :..|.
Mosquito   582 EGAMKIVKMLNE--LYTIFDELTDSKSNS-------------------------------NIYKV 613

  Fly   797 RTVPNAIMAATVLPE 811
            .||.:..||.:.||:
Mosquito   614 ETVGDKYMAVSGLPD 628

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380	2/4 (50%)
		leucine-rich repeat	184..209	CDD:275380	6/28 (21%)
		LRR_8	205..266	CDD:290566	10/78 (13%)
		leucine-rich repeat	210..230	CDD:275380	1/19 (5%)
		leucine-rich repeat	232..255	CDD:275380	4/40 (10%)
		LRR_RI	<256..410	CDD:238064	34/181 (19%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	19/104 (18%)
		leucine-rich repeat	280..303	CDD:275380	8/38 (21%)
		leucine-rich repeat	304..348	CDD:275380	9/52 (17%)
		leucine-rich repeat	349..372	CDD:275380	5/23 (22%)
		PP2Cc	461..655	CDD:294085	39/210 (19%)
AgaP_AGAP000214	XP_310920.4	HNOB	1..163	CDD:285002	32/167 (19%)
		HNOBA	361..547	CDD:285003	44/220 (20%)
		CYCc	527..713	CDD:214485	32/148 (22%)
		Guanylate_cyc	553..745	CDD:278633	22/113 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900