DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Gyc89Db

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_650551.1	Gene:	Gyc89Db / 42002	FlyBaseID:	FBgn0038436	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	358	Identity:	68/358 - (18%)
Similarity:	131/358 - (36%)	Gaps:	89/358 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 RVNLLALVPSRNLKYLDLSGNLQL----QVDEQQFKVCQSQSQ--RHWSLVDVSGNNRAALPTTK 419
            |||::|......:..:||:..|:|    .|.:...|:..:..:  ..|.|.:...|.:..:.:..
  Fly   205 RVNVIAHPSQLKMPSVDLNVFLELFPFTIVLDHDMKITLAGEKIVETWILHNPGVNPKTFIGSHI 269

  Fly   420 IRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALE-GRGRAA 483
            :.:...:|.:: |...|     ||          :.|:|...:         .||.:. |..|||
  Fly   270 LERFKCRRPKD-TQIQW-----ET----------ILQMRTVLF---------EFELIRTGHNRAA 309

  Fly   484 QEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKR- 547
            .:.: |..|.   |...:.|::.:.....|.:|::  .|..:|.........:..::.|...:|
  Fly   310 YDAA-LNFDF---ENFDEASSLNEAQAMALASAKE--FSAENAKEEAAAAATSKDEIDPATGQRR 368

  Fly   548 --YVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMP------DPHVL--ELILSN----- 597
              ..||.....|...|:....|.:.|..|.:...|::|.:.      :||.|  ||:::.
  Fly   369 HSVGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCS 433

  Fly   598 ----------------------DDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQ 640
                                  .|.:...|:..|:|::....|.|..:.||:          :.|
  Fly   434 KLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRKSEEH----------VCQ 488

  Fly   641 SFAAAESLSVIVVRFRHLGTDVDHLIRELKQSV 673
            ||   |.:|||.:...::.....:.|::..|:|
  Fly   489 SF---EEVSVIFIEVMNIYDSGSNNIQDAMQAV 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		LRR_RI	<256..410	CDD:238064	12/54 (22%)
		leucine-rich repeat	256..276	CDD:275380
		LRR_8	279..359	CDD:290566
		leucine-rich repeat	280..303	CDD:275380
		leucine-rich repeat	304..348	CDD:275380
		leucine-rich repeat	349..372	CDD:275380	4/10 (40%)
		PP2Cc	461..655	CDD:294085	45/232 (19%)
Gyc89Db	NP_650551.1	HNOB	2..161	CDD:400167
		HNOBA	218..479	CDD:400168	51/291 (18%)
		Nucleotidyl_cyc_III	488..665	CDD:416391	10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900