DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Gyc88E

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster

Alignment Length:	282	Identity:	56/282 - (19%)
Similarity:	96/282 - (34%)	Gaps:	72/282 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 QTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLL 176
            ||::...|.:..:.|.:  ||   .:|.|:.:.:..:..:......||        ||....|.:
  Fly   259 QTILNRTNNIFELVTVD--PV---TERFDVQNEDLLQHEDGSEPEKSL--------RLKGQMVYM 310

  Fly   177 RNYR------------ITELVSLDLAYNDLKQLDQFPEGFSSIRSLQL----QSNELPSLPDNFF 225
            .|:|            :|.|::..|..|||...|     ||  |.|.|    ||.||....|.
  Fly   311 ENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHD-----FS--RDLMLAGTQQSVELKLALDQ-- 366

  Fly   226 AVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSI---FEPLHNAAKLRVLHLAY 287
              ...:.:.|..|...|.     |:......:...:....:.|.:   ..|:........:.:.:
  Fly   367 --EQQKSKKLEESMRLLD-----EEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILF 424

  Fly   288 NRIGVLPAACVRNWPELEILVLSG--NMLQQLPE-----EVATLGQLRVLRCCNNLLLCTPQLAK 345
            :.|......|.|..|...:.:|:.  ::..:|.|     :|.|:|.                 |.
  Fly   425 SDIVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGD-----------------AY 472

  Fly   346 LAMLKVLDLSHNHLDRVNLLAL 367
            :.:....|...||.:||..:||
  Fly   473 MVVAGAPDKDANHAERVCDMAL 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	10/56 (18%)
		leucine-rich repeat	111..135	CDD:275380	6/22 (27%)
		leucine-rich repeat	136..158	CDD:275380	2/21 (10%)
		leucine-rich repeat	159..183	CDD:275380	6/35 (17%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		LRR_8	205..266	CDD:290566	13/64 (20%)
		leucine-rich repeat	210..230	CDD:275380	7/23 (30%)
		leucine-rich repeat	232..255	CDD:275380	4/22 (18%)
		LRR_RI	<256..410	CDD:238064	20/122 (16%)
		leucine-rich repeat	256..276	CDD:275380	2/22 (9%)
		LRR_8	279..359	CDD:290566	13/86 (15%)
		leucine-rich repeat	280..303	CDD:275380	3/22 (14%)
		leucine-rich repeat	304..348	CDD:275380	7/50 (14%)
		leucine-rich repeat	349..372	CDD:275380	7/19 (37%)
		PP2Cc	461..655	CDD:294085
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572
		HNOBA	201..404	CDD:311573	37/173 (21%)
		CYCc	383..571	CDD:214485	21/129 (16%)
		Herpes_ICP4_C	794..>955	CDD:332854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900