DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and CG43373

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001097622.2	Gene:	CG43373 / 39835	FlyBaseID:	FBgn0263131	Length:	1854	Species:	Drosophila melanogaster

Alignment Length:	998	Identity:	179/998 - (17%)
Similarity:	324/998 - (32%)	Gaps:	316/998 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 EVCENEMEVLDLSSLAQLET------LKCSRNKLME-------------------LIINGTNLQT 113
            ||.|..|..:|..|:..|..      |.|.::.::|                   |::.||::..
  Fly   960 EVNEYLMRAIDARSIDHLRAEHCQSLLLCFKDNVLERKYASEPDRMLCVYFYCSLLVLLGTSIMR 1024

  Fly   114 LVADHNYLHNISTTN--------------THPV----PLKLQRIDI---SHNNFSELPNWVG-AC 156
            ||...:.|..::.:.              .|.:    |..::|..:   |:...|:|..:.. |.
  Fly  1025 LVVFQSSLLTLALSTGALLLLGFLVFLVACHKINFQLPSDIKRFSLRIHSNRRISQLFAFASVAL 1089

  Fly   157 ASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLP 221
            ..||.:.|..........||:..|....|:..::.||           :.:.:....:.|    |
  Fly  1090 IVLTTLLAMFQESGRQMELLQRRRFWLDVNGSISLND-----------TELNTKMYDAEE----P 1139

  Fly   222 DNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLA 286
            |..|.:.:                     |....|..||:    ::.:.::.|....||.:|.||
  Fly  1140 DCDFYLAY---------------------NTFLLLTLLSM----MSCATYQVLRILLKLLLLLLA 1179

  Fly   287 YNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATL--------------------------- 324
            ....    .||..|     :...|..|.|:|..|.|.|
  Fly  1180 SGSY----MACSSN-----LYSRSREMSQELANEEALLRYIIDSIFLFAFMLALIFHSHQTEATY 1235

  Fly   325 --------------GQLRVLRCCNNLLL---CTPQLAK--LAMLKVL-DLSHNHLDRVNLL-ALV 368
                          ..:..|:..|..||   ....:|:  |:..|.| ||.|...|.|.:| |.:
  Fly  1236 RLDFIWKLQATEEKEDMEHLQAYNRKLLENILPVHVAEHFLSREKHLDDLYHEQCDSVCILFASI 1300

  Fly   369 PSRNLKYLDLSGN------LQL----------QVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPT 417
            |:.:..|::|.||      |:|          .:.|::|:..:.......:.:..||........
  Fly  1301 PNFSEFYVELEGNNEGVECLRLLNEIIADFDELLSEERFRCIEKIKSTGATYMAASGLTANTCDR 1365

  Fly   418 TKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLR-AANYG-------GSDEALYGMFE 474
            .....|:|..:       :.:...:.....:....:.:::| ..|.|       |:.:..|.::
  Fly  1366 VNFSHVTAMAD-------YALQLFDKIEEVNMHSFNNFRMRIGINIGPVVAGVIGACKPQYDIW- 1422

  Fly   475 ALEGRGRAAQEMSH-----LVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQC-GSV----RSAALF 529
                 |.|....|.     ||..:...::|.:....|.:        :..| |||    :.:.:.
  Fly  1423 -----GNAVNVASRMDSTGLVDHIQVTQEMQQILEGRGF--------ELTCRGSVDVKGKGSMIT 1474

  Fly   530 HLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTK-PDVI--------QKDQIHSM 585
            :..:.|     ||:.:|.  |.:|.|.      :.....|.|.| |:.:        |::|:...
  Fly  1475 YFLKGR-----RPIDAKE--LELAKTE------VEPPKTLTLAKEPEKLDSGTATEKQREQVKEQ 1526

  Fly   586 PDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSV 650
            ......:.:|.:.|             :|::...:.:..:....|.  |..:|:.||....|.|
  Fly  1527 GSTEQEDDLLPSPD-------------IDMNSNMQNLTAQRRKSLC--RQHNISSSFGTTVSSS- 1575

  Fly   651 IVVRFRHLGTDVDHLIRELKQSVRKKPQPVSL----PLSSGSVCKRTCCDRSNACRHRAIEQEPL 711
                     |.:...|......|.....|..|    |||:.:.      :.:::|.......:.|
  Fly  1576 ---------TGITPSISNSSSVVTIGALPAILRGGNPLSNANP------NATDSCSECGGASKSL 1625

  Fly   712 AGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETE--------SVSESVLSEEQFK 768
            |..::|    .|.|:|..||:         :..::::.:.|..|        ::|.|.||.:|
  Fly  1626 ATPTAP----PRTLVADLKDE---------IARDEKIGLKDSIENLEILLKNNISLSDLSNKQ-- 1675

  Fly   769 CWEYMLEQNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERNDFTSN-----------LMRT 822
                  :||   |..:..::.:.:..|:.|:.:..:..||......|||:           ..|:
  Fly  1676 ------QQN---LRGETSSSTTTTLRKRDTIVSFNVTETVTTTAAPFTSSSGSSNSSSQQKKRRS 1731

  Fly   823 VTN--KFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQAHSYGYNLFDAKPRPKFH 885
            ||.  ...:|||       ||.:.........|..||...|..|.....|...:..|.:||
  Fly  1732 VTTIAASFTTST-------TTRLLSNESQSSTQTAPGTLESGGSVPGQSSTENSSQDWQPR---- 1785

  Fly   886 GGTVKRSAGPNSAYFGSLQRLMP 908
                ..|..||.:...:.|.:.|
  Fly  1786 ----TASLEPNRSPIKTSQSMSP 1804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/43 (14%)
		LRR_8	109..169	CDD:290566	14/81 (17%)
		leucine-rich repeat	111..135	CDD:275380	5/41 (12%)
		leucine-rich repeat	136..158	CDD:275380	5/25 (20%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	3/24 (13%)
		LRR_8	205..266	CDD:290566	8/60 (13%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	1/22 (5%)
		LRR_RI	<256..410	CDD:238064	44/217 (20%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	26/126 (21%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	13/89 (15%)
		leucine-rich repeat	349..372	CDD:275380	10/24 (42%)
		PP2Cc	461..655	CDD:294085	38/219 (17%)
CG43373	NP_001097622.2	AC_N	<523..720	CDD:292831
		CYCc	686..881	CDD:214485
		Guanylate_cyc	722..895	CDD:278633
		DUF1053	<949..1005	CDD:283888	10/44 (23%)
		CYCc	1259..1455	CDD:214485	38/208 (18%)
		Guanylate_cyc	1285..1479	CDD:278633	35/214 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900