DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and CG10738

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_729905.2	Gene:	CG10738 / 39516	FlyBaseID:	FBgn0036368	Length:	1250	Species:	Drosophila melanogaster

Alignment Length:	983	Identity:	178/983 - (18%)
Similarity:	298/983 - (30%)	Gaps:	340/983 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 TFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELII 106
            ||.:|.|....:..|.:.   |:..:|: ||:             |...|:........:.|.|
  Fly   156 TFARTRPPDTQISKSVVA---LLLAFNW-TQV-------------SFLYLDDASGQYQPVAETI- 202

  Fly   107 NGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNN 171
                |.||......:.:|.|.||           |.|:.|.:.|  ..|....|..|      ..
  Fly   203 ----LSTLTDAGVSIRDIRTWNT-----------IYHHGFMDNP--FEALVEQTYAN------TR 244

  Fly   172 VAVLLRNY--RITELVSLD-----------LAYNDLKQLDQF-PEGFSSIRSLQLQSNELPSLPD 222
            :.::|.:|  .:..:|||.           :...|::|.|.. ||.:  :|.|.|:.
  Fly   245 IYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKY--LRGLLLED-------- 299

  Fly   223 NFFAVTHARLETLNVSC--NKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHL 285
                     :|.|.|..  :.|..:|       .|.|:.:...|.:|..:..|..|
  Fly   300 ---------VEPLAVQAFQSYLGIVP-------TASVSFATFANEVNKYMERPPFN--------- 339

  Fly   286 AYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLK 350
                                           .|..:...|.::.:......|.....|...|:::
  Fly   340 -------------------------------FPNPLGPFGGVKQISAEAAYLYDAVHLYAKALME 373

  Fly   351 VLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQ-----QFKVCQSQSQRHWSLVDVSGN 410
            |||......:...::|.:  :..:|....| ..:.:||.     .:.|....|.|       :|.
  Fly   374 VLDSGGRPRNGSAIVAAI--KGSRYRSAMG-YHVYIDENGDAAGNYTVLARGSVR-------NGR 428

  Fly   411 NRAAL----------PTTKIRQVS-AQRNQN-KTSGP--WTMGF--AETP----GSGDCRKLSVY 455
            |:..|          ..:.:..:| |..:|| |...|  |..|.  |..|    |...|...: .
  Fly   429 NQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKCVNYT-G 492

  Fly   456 QLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQC 520
            ::.||..||:...|..:...|....|..||:..|:..:..:|..:.::           ..:||.
  Fly   493 EISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHEN-----------EREQQS 546

  Fly   521 GSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSM 585
            .......|.||.|...|....||                    .||||:.|:           |.
  Fly   547 QKQTRHLLNHLPRRLPPQSTHPL--------------------IRTSQVSLS-----------SN 580

  Fly   586 PDPHVLELILSNDDEYLVV------GNAQLWSVMDIDRAA----REIRKEENSLLAAKR------ 634
            ||.         |..|..:      ...||:::..:.:.:    ||::||...|..|:.
  Fly   581 PDA---------DFRYTTIFTPIGLYKGQLYAIKKVRKKSVDITREMKKELKLLRDARHDNICAF 636

  Fly   635 --------LVDIAQSFAAAESLSVIV----VRFRH--LGTDVDHLIRELKQSVRKKPQPVSLPLS 685
                    .:.|...:....||..|:    |:..:  :.:.|..:||.:   :.....|:..
  Fly   637 IGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGV---IYLHDSPIRF--- 695

  Fly   686 SGSVCKRTCC----------------------DRSNACRH------RAIEQEPLAGRSSPSGQSD 722
            .|::|...|.                      |.|...:|      :.:.:.|...|..||..
  Fly   696 HGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSL-- 758

  Fly   723 RDLLAKDKDDEFVLA------HAR-----------------VLQEEQQLE----MLDETESVSES 760
              ::...:.|.:...      |.|                 |||.:..|.    .|...|:..:.
  Fly   759 --VMGTQRGDAYSFGILLYEMHVRRGPFGETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDC 821

  Fly   761 VLSEEQFKCWEYMLEQNTQLLFDKELNTISKSFTKQRTV-----PNAIMAATVLPERNDFTSNLM 820
            | ||...:||....|..      .:..||.   ||.|.:     ||.......:.|:  :.:||.
  Fly   822 V-SECLRECWAERPEDR------PDFKTIR---TKLRPLRKGMRPNIFDNMMAMMEK--YANNLE 874

  Fly   821 RTVTNKFISTSTPQLPQPITTSVPLGSYHQV------KQAPPGHFGSALSFQQAHSY-----GYN 874
            ..|.::     |.||.:....:..|  .|::      .|...||......::|...|     |:.
  Fly   875 ALVDDR-----TDQLQEEKKKTDAL--LHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFT 932

  Fly   875 LFDAKPRP 882
            ...|:..|
  Fly   933 AMSAECTP 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/18 (17%)
		LRR_8	109..169	CDD:290566	14/59 (24%)
		leucine-rich repeat	111..135	CDD:275380	7/23 (30%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	4/25 (16%)
		leucine-rich repeat	184..209	CDD:275380	8/36 (22%)
		LRR_8	205..266	CDD:290566	11/62 (18%)
		leucine-rich repeat	210..230	CDD:275380	2/19 (11%)
		leucine-rich repeat	232..255	CDD:275380	5/24 (21%)
		LRR_RI	<256..410	CDD:238064	21/158 (13%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	8/79 (10%)
		leucine-rich repeat	280..303	CDD:275380	0/22 (0%)
		leucine-rich repeat	304..348	CDD:275380	4/43 (9%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		PP2Cc	461..655	CDD:294085	41/221 (19%)
CG10738	NP_729905.2	PBP1_Speract_GC_like	41..441	CDD:107365	70/401 (17%)
		ANF_receptor	67..416	CDD:279440	64/369 (17%)
		PK_GC-A_B	570..853	CDD:270944	57/322 (18%)
		TyrKc	597..847	CDD:197581	45/269 (17%)
		HNOBA	<862..907	CDD:285003	9/53 (17%)
		CYCc	886..1078	CDD:214485	10/57 (18%)
		Guanylate_cyc	913..1099	CDD:278633	5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900