DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and caps

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001303391.1	Gene:	caps / 39493	FlyBaseID:	FBgn0023095	Length:	811	Species:	Drosophila melanogaster

Alignment Length:	397	Identity:	96/397 - (24%)
Similarity:	156/397 - (39%)	Gaps:	80/397 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LTQLEVCENEMEVLDLSS--LAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPV 132
            :.:|.:..|:::.:|.|.  .|||..|..|.|.::           .:.:.::.::
  Fly    74 IQRLVIKNNKLKTIDSSMQFYAQLTFLDLSFNDML-----------TIPERSFAYH--------- 118

  Fly   133 PLKLQRIDISHNNFSELPN--WVGACASLTAINASHNRLNNVAVLLRNYR----ITELVSLDLAY 191
             .|||.:.:.||...::.|  ::|    |:.|:..:.|.|.:|.|  .||    :.:|..|:|..
  Fly   119 -AKLQELHLDHNKIGQVSNKTFLG----LSTISVLNLRGNLIAEL--EYRTFSPMVKLAELNLGQ 176

  Fly   192 NDLKQLDQFP-EGFSSIRSLQLQSNELPSLPDNF-FAVTHARLETLNVSCNKLSTLPRYEQNNHA 254
            |.:..:|... :|..::|.|.|..|.|.::|... |...|: |..|.:..|...|:|.....:..
  Fly   177 NRISHIDPHALDGLDNLRVLYLDDNTLTTVPGELTFQALHS-LAELYLGTNSFMTIPGGAFQDLK 240

  Fly   255 ALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPE 319
            .|..|.|.|..|::...:.|.....||.|.|:.||:..:|.|..:....||.|.:..|..
  Fly   241 GLTRLDLRGAGLHNISGDALKGLVSLRFLDLSDNRLPAIPTAAFQRLGRLEQLNIGQNDF----- 300

  Fly   320 EVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQL 384
            ||.:.|....||...:|.|...|               .|.||...|...:.||::|:||.|.||
  Fly   301 EVISSGAFSGLRELRHLELTGAQ---------------RLRRVESGAFSGNTNLEHLNLSSNKQL 350

  Fly   385 QVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPW----TMGFAETPG 445
                .:..........|.|.|.:..|..::|....:              ||    |:..:|.|.
  Fly   351 ----NELSSIALGGLPHLSTVVLKANQLSSLDEGLV--------------PWADLQTLDLSENPF 397

  Fly   446 SGDCRKL 452
            ..|||.|
  Fly   398 ECDCRLL 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/18 (22%)
		LRR_8	109..169	CDD:290566	9/61 (15%)
		leucine-rich repeat	111..135	CDD:275380	0/23 (0%)
		leucine-rich repeat	136..158	CDD:275380	6/23 (26%)
		leucine-rich repeat	159..183	CDD:275380	8/27 (30%)
		leucine-rich repeat	184..209	CDD:275380	6/25 (24%)
		LRR_8	205..266	CDD:290566	17/61 (28%)
		leucine-rich repeat	210..230	CDD:275380	6/20 (30%)
		leucine-rich repeat	232..255	CDD:275380	5/22 (23%)
		LRR_RI	<256..410	CDD:238064	41/153 (27%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	20/79 (25%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	12/43 (28%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		PP2Cc	461..655	CDD:294085
caps	NP_001303391.1	leucine-rich repeat	75..96	CDD:275380	4/20 (20%)
		LRR_8	96..155	CDD:290566	16/83 (19%)
		leucine-rich repeat	97..120	CDD:275380	4/43 (9%)
		leucine-rich repeat	121..144	CDD:275380	7/26 (27%)
		LRR_8	143..201	CDD:290566	16/59 (27%)
		leucine-rich repeat	145..168	CDD:275380	7/24 (29%)
		LRR_RI	147..397	CDD:238064	72/290 (25%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		leucine-rich repeat	193..217	CDD:275380	7/23 (30%)
		LRR_8	217..276	CDD:290566	16/59 (27%)
		leucine-rich repeat	218..241	CDD:275380	5/22 (23%)
		leucine-rich repeat	242..265	CDD:275380	6/22 (27%)
		LRR_8	265..321	CDD:290566	19/60 (32%)
		leucine-rich repeat	266..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..313	CDD:275380	8/27 (30%)
		LRR_8	312..374	CDD:290566	20/80 (25%)
		leucine-rich repeat	314..335	CDD:275380	7/35 (20%)
		leucine-rich repeat	339..363	CDD:275380	7/27 (26%)
		LRRCT	395..445	CDD:214507	5/10 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910