DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and CG6749

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_648354.1	Gene:	CG6749 / 39144	FlyBaseID:	FBgn0036040	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	462	Identity:	122/462 - (26%)
Similarity:	197/462 - (42%)	Gaps:	89/462 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KSKLKVSASHSGPH---PLPVEVTAAEEEQAATFGQT---SPQKLSLKGSQLGGSILIGNY---- 67
            :::|:|.:..:..|   .|.:::|.|......|.|.:   :.::|:|.|..|..  :.||:
  Fly    65 QTELEVGSGENADHLANLLDLDLTGAAPINVHTNGFSILPNLRQLNLSGCGLVD--IRGNHFAPE 127

  Fly    68 NYLTQLEVCENEMEVLD---LSSLAQLETLKCSRNKLMEL-IINGTNLQTLVADHNYLHNISTTN 128
            :.|.:::...|:||:||   ..:|.:|.....|.|.|.:. :.:...|..|...||.|.|.
  Fly   128 SALQRIDFSHNQMELLDRDFFGNLRKLIYANFSHNALKQCDLPHMPLLNRLELGHNRLVNA---- 188

  Fly   129 THPVPLKLQRIDISHNNFSELP-NWVGACASLTAINASHNRLNNVAVLLRNYR-ITELVSLDLAY 191
            |..|..:||.:.::.|...:|. |.......|..:..|.|||:::.  |..:: :.:|..|:|:.
  Fly   189 TFGVCPQLQELILNDNQLIQLDVNAFRGLHGLLELQLSGNRLSSIG--LETFQPLAQLRKLNLSQ 251

  Fly   192 NDLKQLDQFPEGFSSIRS-------LQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYE 249
            |.|..|.  |..|.::::       |.|..|.:..|.||.|.|. |||:.|:||.|.:::|
  Fly   252 NALDALR--PNVFGAVQNFVLHLQQLDLSGNRIRLLFDNQFRVL-ARLQMLDVSRNSIASL---- 309

  Fly   250 QNNHAALVNLSLAGNHLNDSIFEPLH--NAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGN 312
                                  .|.|  ....||.|:|.||.|..:..|.......|:.|.||.|
  Fly   310 ----------------------SPAHFVGLGSLRKLYLQYNAILEIKPATFAALLNLDTLDLSYN 352

  Fly   313 MLQQLPEEV---ATLGQLRVLRCCNNLLLCTPQLA--KLAMLKVLDLSHNHLDRVNLLALVPSRN 372
            .|:.|.|::   .||.::|.|....|.:.....||  .|..|:.|.|.||.|..:::....|.|.
  Fly   353 NLEFLEEQIFGGNTLPRMRRLNLNGNRMKHLHPLAFSSLPFLEYLKLGHNELKSLDVRMFAPMRR 417

  Fly   373 LKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNR--------AALPTTKIRQVSAQRNQ 429
            |:.|.|..||   ::|....|.:|.|.....|||   |||        .:.|  .:::|:.:.|
  Fly   418 LQKLHLGHNL---LEEINLDVLESLSSVQEILVD---NNRLTFLAKVNVSFP--NLKRVAIEGN- 473

  Fly   430 NKTSGPW 436
                 ||
  Fly   474 -----PW 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/19 (21%)
		LRR_8	109..169	CDD:290566	16/60 (27%)
		leucine-rich repeat	111..135	CDD:275380	8/23 (35%)
		leucine-rich repeat	136..158	CDD:275380	5/22 (23%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		LRR_8	205..266	CDD:290566	16/67 (24%)
		leucine-rich repeat	210..230	CDD:275380	8/19 (42%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	46/160 (29%)
		leucine-rich repeat	256..276	CDD:275380	2/21 (10%)
		LRR_8	279..359	CDD:290566	29/84 (35%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	16/48 (33%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		PP2Cc	461..655	CDD:294085
CG6749	NP_648354.1	LRR_RI	103..>256	CDD:238064	41/160 (26%)
		LRR_8	104..164	CDD:290566	16/61 (26%)
		leucine-rich repeat	106..129	CDD:275380	6/24 (25%)
		leucine-rich repeat	130..153	CDD:275380	7/22 (32%)
		leucine-rich repeat	154..195	CDD:275380	12/44 (27%)
		LRR_RI	194..455	CDD:238064	84/297 (28%)
		LRR_8	194..254	CDD:290566	15/61 (25%)
		leucine-rich repeat	196..219	CDD:275380	5/22 (23%)
		leucine-rich repeat	220..243	CDD:275380	6/24 (25%)
		leucine-rich repeat	244..267	CDD:275380	8/24 (33%)
		LRR_8	271..330	CDD:290566	24/85 (28%)
		leucine-rich repeat	272..295	CDD:275380	8/23 (35%)
		leucine-rich repeat	296..319	CDD:275380	8/48 (17%)
		LRR_8	319..380	CDD:290566	21/60 (35%)
		leucine-rich repeat	320..343	CDD:275380	8/22 (36%)
		leucine-rich repeat	344..369	CDD:275380	10/24 (42%)
		LRR_8	368..428	CDD:290566	19/62 (31%)
		leucine-rich repeat	370..393	CDD:275380	6/22 (27%)
		leucine-rich repeat	394..417	CDD:275380	7/22 (32%)
		leucine-rich repeat	418..441	CDD:275380	8/25 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910