DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and ltl

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001261524.1	Gene:	ltl / 38845	FlyBaseID:	FBgn0268063	Length:	817	Species:	Drosophila melanogaster

Alignment Length:	356	Identity:	96/356 - (26%)
Similarity:	164/356 - (46%)	Gaps:	50/356 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LTQLEVCENEMEVLDLSSLAQ-LETLKCSRNKLMELIINGT-----NLQTLVADHNYLHNISTTN 128
            :|.|.:..|.:..||..|..: |..|...||:|..|  ||:     ||::|..:.|   ||::.:
  Fly   159 VTNLILVSNIITRLDRGSFPKSLLILHLGRNQLESL--NGSLHDLHNLESLFINAN---NITSLD 218

  Fly   129 THPVPLKLQRIDISHNN-FSELPNWVGACASLTAINASHNRLNNVAVLLRN-YRITELVSLDLAY 191
            .........|:.::||| ...||..:....||..::...|:|.:...:||| ..::|:::.:
  Fly   219 DELPDGGQLRLLMAHNNRLERLPANMAGMHSLETVHIHCNQLRSFDRVLRNAVNLSEVMADN--- 280

  Fly   192 NDLKQL--DQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHAR----------------------L 232
            |:|:.|  |:| ...|.:.:||:..|.:.||..:...:...:                      |
  Fly   281 NELEYLAQDEF-ASCSKVETLQMGCNHIKSLNSSLLPILKLKNANFSFNDIEEFSMAELHGLRSL 344

  Fly   233 ETLNVSCNKLSTL---PRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLP 294
            :||.:|.|::..|   ||..|  ...||||.|..|.: ||:...|.....||:|:||.||:..|.
  Fly   345 KTLQLSSNRIQRLLPDPRGVQ--ELMLVNLDLDNNRI-DSLNGALAGLGNLRILNLAGNRLEHLQ 406

  Fly   295 AACVRNWPELEILVLSGNMLQQL-PEEVATLGQLRVLRCC-NNLLLCTPQLAKLAMLKVLDLSHN 357
            .........|:||.|:||.|.:| |.|:..|..|::|:.. ||:.........|.:|...:|::|
  Fly   407 VGDFDGMIRLDILDLTGNQLAELKPLEMTLLPSLKILKVAYNNITKLEQDFKGLPVLCQANLTNN 471

  Fly   358 HLDRVNLLALVPSRNLKYLDLSGNLQLQVDE 388
            .:..:: ..||.:...|..::.|.|::.:|:
  Fly   472 QISTIS-SELVTNTRCKNHNVPGKLEIHLDD 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	8/23 (35%)
		LRR_8	109..169	CDD:290566	15/65 (23%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	6/22 (27%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	6/26 (23%)
		LRR_8	205..266	CDD:290566	21/85 (25%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	9/25 (36%)
		LRR_RI	<256..410	CDD:238064	42/135 (31%)
		leucine-rich repeat	256..276	CDD:275380	9/19 (47%)
		LRR_8	279..359	CDD:290566	27/81 (33%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	16/45 (36%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085
ltl	NP_001261524.1	leucine-rich repeat	65..86	CDD:275380
		LRR_8	86..145	CDD:290566
		leucine-rich repeat	87..110	CDD:275380
		leucine-rich repeat	111..134	CDD:275380
		leucine-rich repeat	135..158	CDD:275380
		LRR_8	158..214	CDD:290566	18/59 (31%)
		leucine-rich repeat	159..180	CDD:275380	6/20 (30%)
		leucine-rich repeat	181..203	CDD:275380	8/23 (35%)
		leucine-rich repeat	204..226	CDD:275380	5/24 (21%)
		LRR_RI	226..451	CDD:238064	66/231 (29%)
		leucine-rich repeat	227..249	CDD:275380	6/21 (29%)
		leucine-rich repeat	250..272	CDD:275380	6/21 (29%)
		leucine-rich repeat	273..296	CDD:275380	6/26 (23%)
		leucine-rich repeat	297..315	CDD:275380	5/17 (29%)
		LRR_8	319..402	CDD:290566	24/85 (28%)
		leucine-rich repeat	320..335	CDD:275378	0/14 (0%)
		leucine-rich repeat	344..366	CDD:275380	9/23 (39%)
		leucine-rich repeat	367..391	CDD:275380	9/24 (38%)
		LRR_8	369..426	CDD:290566	23/57 (40%)
		leucine-rich repeat	392..415	CDD:275380	8/22 (36%)
		leucine-rich repeat	416..439	CDD:275380	11/22 (50%)
		LRR_8	438..>479	CDD:290566	8/41 (20%)
		leucine-rich repeat	440..462	CDD:275380	5/21 (24%)
		leucine-rich repeat	463..483	CDD:275380	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910