DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Lrt

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001286640.1	Gene:	Lrt / 37342	FlyBaseID:	FBgn0034540	Length:	830	Species:	Drosophila melanogaster

Alignment Length:	636	Identity:	144/636 - (22%)
Similarity:	231/636 - (36%)	Gaps:	189/636 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCEN-EMEVLDLSSL 88
            ||.|...:........|...:|||..:||....|      .|..:|:..::.:| .:..|.:||
  Fly   150 PHTLRCNIDLHGMMLLADRLRTSPYSISLLDCSL------RNVTFLSDAKIFDNVSLHGLVISS- 207

  Fly    89 AQLETLKCS-----RNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSE 148
            .:::.:..|     |..|..|.:.|..|.::  ..|.|..:|.         |:|:|:::|....
  Fly   208 GEIKRVHKSAFLGIRGPLQALGLPGNALMSV--PWNALSTLSA---------LERLDLANNKIKA 261

  Fly   149 L--PNWVGACASLTAINASHNRLNNVA----VLLRNYRITELVSLDLAYNDLKQLDQFPEGFS-- 205
            |  .::|| ..||..:..|:|::::::    |.||...:     |.|..|.|....|.....|
  Fly   262 LGTADFVG-LTSLVYLELSNNQISSISQRTFVNLRKLEV-----LKLGGNRLGDYAQSLRSLSQC 320

  Fly   206 -SIRSLQLQSNEL------PSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAG 263
             |:|.|.||:|.|      .:||.      ...||:||::.|.:.::......|.:.||:|||..
  Fly   321 LSLRQLDLQANNLNGPLSEQTLPG------MRNLESLNLNRNLIKSIQNKALANFSRLVSLSLRH 379

  Fly   264 NH---LNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLG 325
            |.   |.|..|..|   ..|..|.|:||.|..:.:|
  Fly   380 NQIDVLQDHAFFGL---GALDSLDLSYNGIVAISSA----------------------------- 412

  Fly   326 QLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQ 390
                            .|..|:.|.||||:||.|..:....:.|..:|:.|.|:||
  Fly   413 ----------------SLQHLSRLTVLDLTHNFLRALTSDLIAPLPSLRELRLAGN--------- 452

  Fly   391 FKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVY 455
                           |:|...|.|:...  |::.:.:.|            |.|.|.||
  Fly   453 ---------------DISIVARNAMDGA--RELESLQMQ------------ENPLSCDC------ 482

  Fly   456 QLRAANYGGSDEALYGMFEA-------LEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTL 513
            .:|.......:..|:....|       |||.......:..|..|:   :.:.||:|  :.|:
  Fly   483 SIRPFAEWLQESQLHSSLSASCVTPPRLEGAPLLQVPVETLSCDM---DNVEKDNA--NIMQ--- 539

  Fly   514 LAAQQQCGSVRSAALFHLTRTRAPSKVRPLK--SKRYVLRMA--STGGLDAYLIRRTSQLRLTKP 574
                            ||.....|::..|:|  |:..:|...  ||.    |.:..|..|.|:|.
  Fly   540 ----------------HLETLAKPNQTSPIKDLSEEIILHELHFSTD----YGLILTWLLNLSKK 584

  Fly   575 DVIQKDQIHSMPDPHVLELILSNDD---EYLVVGNAQLWSVMDIDRAAREI 622
            |.: .|.|....:.|:.|:::.|..   |..||......||:..|.::.||
  Fly   585 DYM-CDAIFVYKEEHINEILIDNSPIHCESKVVNGQNTVSVIVPDSSSLEI 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/23 (22%)
		LRR_8	109..169	CDD:290566	15/61 (25%)
		leucine-rich repeat	111..135	CDD:275380	4/23 (17%)
		leucine-rich repeat	136..158	CDD:275380	7/23 (30%)
		leucine-rich repeat	159..183	CDD:275380	6/27 (22%)
		leucine-rich repeat	184..209	CDD:275380	7/27 (26%)
		LRR_8	205..266	CDD:290566	22/72 (31%)
		leucine-rich repeat	210..230	CDD:275380	7/25 (28%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	35/156 (22%)
		leucine-rich repeat	256..276	CDD:275380	10/22 (45%)
		LRR_8	279..359	CDD:290566	16/79 (20%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	2/43 (5%)
		leucine-rich repeat	349..372	CDD:275380	9/22 (41%)
		PP2Cc	461..655	CDD:294085	39/176 (22%)
Lrt	NP_001286640.1	LRR_RI	<151..334	CDD:238064	50/206 (24%)
		leucine-rich repeat	179..199	CDD:275378	4/25 (16%)
		leucine-rich repeat	200..223	CDD:275380	4/23 (17%)
		leucine-rich repeat	225..248	CDD:275380	6/24 (25%)
		LRR_8	249..307	CDD:290566	17/63 (27%)
		leucine-rich repeat	249..272	CDD:275380	7/23 (30%)
		LRR_RI	<270..479	CDD:238064	69/305 (23%)
		leucine-rich repeat	273..296	CDD:275380	5/22 (23%)
		leucine-rich repeat	297..322	CDD:275380	6/29 (21%)
		LRR_8	322..382	CDD:290566	21/65 (32%)
		leucine-rich repeat	323..347	CDD:275380	8/29 (28%)
		leucine-rich repeat	348..371	CDD:275380	6/22 (27%)
		LRR_8	370..428	CDD:290566	24/105 (23%)
		leucine-rich repeat	372..395	CDD:275380	10/25 (40%)
		leucine-rich repeat	396..419	CDD:275380	9/67 (13%)
		LRR_8	418..478	CDD:290566	21/97 (22%)
		leucine-rich repeat	420..443	CDD:275380	9/22 (41%)
		leucine-rich repeat	444..467	CDD:275380	9/48 (19%)
		LRRCT	476..526	CDD:214507	11/55 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910