DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Toll-7

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_523797.1	Gene:	Toll-7 / 37272	FlyBaseID:	FBgn0034476	Length:	1446	Species:	Drosophila melanogaster

Alignment Length:	1321	Identity:	251/1321 - (19%)
Similarity:	384/1321 - (29%)	Gaps:	587/1321 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIING-TNLQTL 114
            |.|:|:.....:.|    ..::|.:.|:.:.|...:.|..||.|:....||::|..|. ..|.||
  Fly   100 LDLQGADGSSQLTI----QCSELYLFESTLPVAVFARLQTLEALRLDSCKLLQLPNNAFEGLATL 160

  Fly   115 VADHNYLHNISTTNTHPVPL---------KLQRIDISHNNFSELPNW----VG------------ 154
            .:.....||.....|..:.|         :|..:|:..||..:||:.    ||
  Fly   161 KSLRLSTHNSEWGPTRTLELFPDSLGGLKQLTDLDLGDNNLRQLPSGFLCPVGNLQVLNLTRNRI 225

  Fly   155 -------------------ACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLD-Q 199
                               |.:.|..::||||.|.:::......|:..|..|:||||:|.:|. :
  Fly   226 RTAEQMGFADMNCGAGSGSAGSELQVLDASHNELRSISESWGISRLRRLQHLNLAYNNLSELSGE 290

  Fly   200 FPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLP-----RYEQ--------- 250
            ...|.:|:|.:.|.:|.|.:||:..||.: ..|..:::..|:|..||     |.||
  Fly   291 ALAGLASLRIVNLSNNHLETLPEGLFAGS-KELREIHLQQNELYELPKGLFHRLEQLLVVDLSGN 354

  Fly   251 ---NNHA---------ALVNLSLAGN---------------------------HLNDSIFEPLHN 276
               :||.         .|:.|:||.|                           |:.|:.|.||:|
  Fly   355 QLTSNHVDNTTFAGLIRLIVLNLAHNALTRIDYRTFKELYFLQILNLRNNSIGHIEDNAFLPLYN 419

  Fly   277 AAKLRVLHLAYNR------------------------IGVLPAACVRNWPELEILVLSGNMLQQL 317
               |..|:||.||                        |.|:..|..:|..:|:.|.||.|.|.::
  Fly   420 ---LHTLNLAENRLHTLDDKLFNGLYVLSKLTLNNNLISVVEPAVFKNCSDLKELDLSSNQLNEV 481

  Fly   318 PEEVATLGQLRVLRCCNN------------------LLLCTPQLAKLAM--------LKVLDLSH 356
            |..:..|..||.|....|                  |.|...|:..:.:        |.||:|:.
  Fly   482 PRALQDLAMLRTLDLGENQIRTFDNQSFKNLHQLTGLRLIDNQIGNITVGMFQDLPRLSVLNLAK 546

  Fly   357 N-------------------HLDR-------------VNLL--------------ALVPSRNLKY 375
            |                   .|||             |:||              |.:|| |||:
  Fly   547 NRIQSIERGSFDKNFELEAIRLDRNFLADINGVFATLVSLLWLNLSENHLVWFDYAFIPS-NLKW 610

  Fly   376 LDLSGN--------LQLQVDEQQFKVCQSQSQR-------------------------------- 400
            ||:.||        .:|| :|.:.|...:...|
  Fly   611 LDIHGNYIEALGNYYKLQ-EEIRVKTLDASHNRITEIGPMSIPNTIELLFINNNLIGNVQPNAFV 674

  Fly   401 ---HWSLVDVSGNNRAALPTTKIRQVSA-------------------------QRNQNKTSG--- 434
               :.:.||:..|..:.|...::|....                         ||..|.|:.
  Fly   675 DKANLARVDLYANQLSKLQLQQLRVAPVVAPKPLPEFYLGGNPFECDCTMDWLQRINNLTTRQHP 739

  Fly   435 ------------PWTMGFAETPGSG--------------------------DCRKL--------- 452
                        |...|.|..|.||                          ||...
  Fly   740 RVMDMANIECVMPHARGAAVRPLSGLRPQDFLCRYESHCFALCHCCDFDACDCEMTCPSNCTCYH 804

  Fly   453 -SVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPD-----LMKQEQMVKDSAVRD-YMK 510
             .::.....:.||.        :..|...|...:.|.:..|     ::|....:....:|. |:.
  Fly   805 DQIWSTNVVDCGGQ--------QTTELPRRVPMDSSVVYLDGNNFPVLKNHAFIGRKNLRALYVN 861

  Fly   511 FTLLAAQQQ--CGSVRSAALFHLTRTRAPSKVRPLKSKRY-----------------VLRMASTG 556
            .:.:||.|.  ..|:.|..|.||    |.:|:|.|....:                 .:..|:..
  Fly   862 GSQVAAIQNRTFASLASLQLLHL----ADNKLRTLHGYEFEQLSALRELYLQNNQLTTIENATLA 922

  Fly   557 GLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSND-----------------DEYLVV 604
            .|.|..:.|....||....:.|....|.  ...:..:.|..:                 |..|:|
  Fly   923 PLAALELIRIDGNRLVTLPIWQMHATHF--GTRLKSISLGRNQWSCRCQFLQALTSYVADNALIV 985

  Fly   605 GNAQLWSVMDIDRAAREIRKEENS----------------------------------------L 629
            .:||....|...........|::|                                        |
  Fly   986 QDAQDIYCMAASSGTGSAALEDSSSNSGSLEKRELDFNATGAACTDYYSGGSMLQHGIPESYIPL 1050

  Fly   630 LAAK-----RLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSV 689
            |||.     .||.||..||..|||.:.:  |.|.|..|                       .|..
  Fly  1051 LAAALALLFLLVVIAMVFAFRESLRIWL--FAHYGVRV-----------------------FGPR 1090

  Fly   690 CKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAH-----------ARVLQ 743
            |:               |.|.|         .|..||...||.|||..|           .||..
  Fly  1091 CE---------------ESEKL---------YDAVLLHSAKDSEFVCQHLAAQLETGRPPLRVCL 1131

  Fly   744 EEQQL-------EMLDETESVSESV--------LSEEQFKCWEYMLEQNTQLLFDKELNTISKSF 793
            :.:.|       ::|:.|. ||..|        |..|..:|               ||
  Fly  1132 QHRDLAHDATHYQLLEATR-VSRRVVILLTRNFLQTEWARC---------------EL------- 1173

  Fly   794 TKQRTVPNAIMAATVLPERNDFTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSY------HQVK 852
              :|:|.:|                 :|....|.:....|::.....:.:.|..|      |:::
  Fly  1174 --RRSVHDA-----------------LRGRPQKLVIIEEPEVAFEAESDIELLPYLKTSAVHRIR 1219

  Fly   853 QAPPGHFGSALSFQQAHSYGYNLFDAKPRPKFHGGT------------VKRSAGPNSAY------ 899
            :: ..||...|.:.....|          |.|.|..            ||:.|.|...|
  Fly  1220 RS-DRHFWEKLRYALPVDY----------PTFRGNNYTLELDHHNHERVKQPASPGLLYRQAPPP 1273

  Fly   900 ----------FGSLQRLMPYN 910
                      .|::.:::|.|
  Fly  1274 AYCGPADAVGIGAVPQVVPVN 1294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/19 (37%)
		LRR_8	109..169	CDD:290566	21/103 (20%)
		leucine-rich repeat	111..135	CDD:275380	7/32 (22%)
		leucine-rich repeat	136..158	CDD:275380	9/56 (16%)
		leucine-rich repeat	159..183	CDD:275380	7/23 (30%)
		leucine-rich repeat	184..209	CDD:275380	10/25 (40%)
		LRR_8	205..266	CDD:290566	24/113 (21%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	10/48 (21%)
		LRR_RI	<256..410	CDD:238064	64/319 (20%)
		leucine-rich repeat	256..276	CDD:275380	10/46 (22%)
		LRR_8	279..359	CDD:290566	30/148 (20%)
		leucine-rich repeat	280..303	CDD:275380	10/46 (22%)
		leucine-rich repeat	304..348	CDD:275380	15/61 (25%)
		leucine-rich repeat	349..372	CDD:275380	14/68 (21%)
		PP2Cc	461..655	CDD:294085	51/280 (18%)
Toll-7	NP_523797.1	LRR_8	135..201	CDD:290566	17/65 (26%)
		leucine-rich repeat	136..159	CDD:275380	8/22 (36%)
		leucine-rich repeat	160..190	CDD:275380	5/29 (17%)
		LRR_8	189..259	CDD:290566	14/69 (20%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		leucine-rich repeat	215..248	CDD:275380	1/32 (3%)
		LRR_RI	247..501	CDD:238064	68/257 (26%)
		LRR_8	247..308	CDD:290566	20/60 (33%)
		leucine-rich repeat	249..273	CDD:275380	7/23 (30%)
		leucine-rich repeat	274..297	CDD:275380	9/22 (41%)
		LRR_8	297..356	CDD:290566	17/59 (29%)
		leucine-rich repeat	298..321	CDD:275380	8/23 (35%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	345..406	CDD:290566	8/60 (13%)
		leucine-rich repeat	346..371	CDD:275380	2/24 (8%)
		leucine-rich repeat	372..395	CDD:275380	5/22 (23%)
		leucine-rich repeat	396..419	CDD:275380	5/22 (23%)
		LRR_8	419..478	CDD:290566	16/61 (26%)
		leucine-rich repeat	420..443	CDD:275380	6/22 (27%)
		leucine-rich repeat	444..467	CDD:275380	4/22 (18%)
		LRR_RI	466..622	CDD:238064	36/156 (23%)
		leucine-rich repeat	468..488	CDD:275380	7/19 (37%)
		LRR_8	491..549	CDD:290566	12/57 (21%)
		leucine-rich repeat	491..514	CDD:275380	4/22 (18%)
		leucine-rich repeat	515..536	CDD:275380	3/20 (15%)
		leucine-rich repeat	539..562	CDD:275380	5/22 (23%)
		leucine-rich repeat	563..585	CDD:275380	3/21 (14%)
		leucine-rich repeat	586..626	CDD:275380	12/40 (30%)
		leucine-rich repeat	627..653	CDD:275380	5/26 (19%)
		LRRCT	716..772	CDD:214507	10/55 (18%)
		LRRNT	796..830	CDD:214470	4/41 (10%)
		leucine-rich repeat	812..829	CDD:275380	4/24 (17%)
		leucine-rich repeat	833..854	CDD:275380	2/20 (10%)
		LRR_8	853..913	CDD:290566	14/63 (22%)
		leucine-rich repeat	855..878	CDD:275380	6/22 (27%)
		LRR_4	878..918	CDD:289563	8/43 (19%)
		leucine-rich repeat	879..902	CDD:275380	7/26 (27%)
		leucine-rich repeat	903..926	CDD:275380	2/22 (9%)
		leucine-rich repeat	927..953	CDD:275380	5/27 (19%)
		TIR	1098..1235	CDD:214587	34/179 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910