DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and CG33958

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001033958.1	Gene:	CG33958 / 37088	FlyBaseID:	FBgn0053958	Length:	710	Species:	Drosophila melanogaster

Alignment Length:	721	Identity:	129/721 - (17%)
Similarity:	252/721 - (34%)	Gaps:	225/721 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KATRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNY 67
            ||.:...:|..|......|......:.::::..:..:... .:|:|..::..|.  ||.:|:..:
  Fly     5 KAHKSGENPDPSPCPAGGSRMPTPSVKIDISTCQSNRPME-SRTAPDDVNPSGE--GGLLLVPTH 66

  Fly    68 NYLTQLEVCENEMEVLDLS---------SLAQLETLKCSRN-KLMELII------------NGTN 110
            :.|...::....:...|:|         :.|:...:|..|. :||::||            ....
  Fly    67 HNLQLDKISVRSISSEDISNGGSGRCCNAAARNPAIKTGRRLQLMQMIILPFIPILALIVQTSVT 131

  Fly   111 LQTLVADHNYLHNISTTNTHPVP-------LKLQRIDISHNNFSELPNWVGACASLTA--INASH 166
            ||.::...:.:.:|.|..|....       |:|:|.:::...|:   |.....|:||.  .|..|
  Fly   132 LQEILEYRSAVADIETQVTIATDLGKVVTRLQLERSEVAFYIFT---NGSKQRANLTLRFANTDH 193

  Fly   167 NRLNNVA-------------------VLLRNYR--------------------ITELVSLDLAYN 192
             .|||:.                   ::|..|.                    |||:::...:.|
  Fly   194 -ALNNMTTWSEISVPTAPDEDEDDREMMLNRYEFQSRLNEFRDRVRLEPEESSITEVMNWYTSIN 257

  Fly   193 ---------DLKQLD-----QFPEGFSS-IRSLQLQSNELPSL-----------PDNFFAVTHAR 231
                     .:|:.|     ::..||.: ::|::.| |...|.           .:||  |::.|
  Fly   258 RGLLHHLSEQIKETDNSGVWRYLVGFKNLLKSIECQ-NIATSFGIRYYGRGSLTAENF--VSYVR 319

  Fly   232 LE---------TLNVS---CNKLSTLPRYEQNNHAALVNLSLAGNHLNDS-------IFEPLHN- 276
            .|         |||.:   .|..:.:...::.:.|..:..:|..|:.|.|       .:|.::|
  Fly   320 YEFMAREMINSTLNYAPMLKNMYTNITSTKKFHRAKQMGTTLLKNNPNVSNERSAIEYYELMNNY 384

  Fly   277 AAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTP 341
            ...||:|..|..|:       ::.:       :...:::...:|...:..|.|      :|:.:|
  Fly   385 TDDLRILQKALRRL-------IKEY-------VDKTLVEADRKEAIGIAILVV------VLIVSP 429

  Fly   342 QLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVD 406
                    .::.|..|....:.|.||             ||     .|:.|..:.:.::..||:.
  Fly   430 --------VIIVLVKNAAATIQLYAL-------------NL-----SQKAKELKREKRKSDSLLF 468

  Fly   407 VSGNNRAALPTTKIRQVSAQRNQNKT---SGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEA 468
            .......|:...:.:||.|:..:..|   |.  .:||.|.  :.||..|.|.....:.|...||.
  Fly   469 QMLPPSVAMQLKQTQQVPAELYEAVTIYFSD--IVGFTEI--AADCTPLEVVTFLNSIYRVFDER 529

  Fly   469 L--YGMFEA--------------LEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQ 517
            :  |.:::.              ::...:...|::.:..||:....:.:.....|..      .|
  Fly   530 IECYDVYKVETIGDSYMVASGLPVKNGNKHISEIATMALDLLDASSVFRIPRAGDEF------VQ 588

  Fly   518 QQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVL---------RMASTGGLDAYLIRRTSQLRLTK 573
            .:||......:..:..|:.|         ||.|         ||.|||  :|..|..|.::.
  Fly   589 IRCGVHTGPVVAGIVGTKMP---------RYCLFGDTVNTASRMESTG--EAQKIHITEEMH--- 639

  Fly   574 PDVIQK 579
             |.:|:
  Fly   640 -DSLQQ 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/31 (19%)
		LRR_8	109..169	CDD:290566	15/68 (22%)
		leucine-rich repeat	111..135	CDD:275380	5/30 (17%)
		leucine-rich repeat	136..158	CDD:275380	4/21 (19%)
		leucine-rich repeat	159..183	CDD:275380	10/64 (16%)
		leucine-rich repeat	184..209	CDD:275380	5/39 (13%)
		LRR_8	205..266	CDD:290566	16/84 (19%)
		leucine-rich repeat	210..230	CDD:275380	6/30 (20%)
		leucine-rich repeat	232..255	CDD:275380	5/34 (15%)
		LRR_RI	<256..410	CDD:238064	27/161 (17%)
		leucine-rich repeat	256..276	CDD:275380	5/26 (19%)
		LRR_8	279..359	CDD:290566	12/79 (15%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	5/43 (12%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	26/144 (18%)
CG33958	NP_001033958.1	NIT	159..396	CDD:285564	47/243 (19%)
		HNOBA	<439..479	CDD:285003	10/57 (18%)
		CYCc	459..647	CDD:214485	41/211 (19%)
		Guanylate_cyc	485..669	CDD:278633	37/185 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900