DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Lrrc1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001014290.1	Gene:	Lrrc1 / 367113	RGDID:	1549773	Length:	524	Species:	Rattus norvegicus

Alignment Length:	465	Identity:	115/465 - (24%)
Similarity:	181/465 - (38%)	Gaps:	115/465 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 IGNYNYLTQLEVCENE-------------MEVLDLS---------SLAQLETLKCSRNKLMELII 106
            |.|:..|.:|:|..|:             ::|.|.|         |..:|:.|.|       |.:
  Rat    78 IANFMQLVELDVSRNDIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC-------LSV 135

  Fly   107 NGTNLQTLVADHNYLHNISTTNTH-------PVPL----KLQRIDISHNNFSELPNWVGACASLT 160
            |..:||:|..:...|:|:::....       |..|    :|:.:|:.:|....||..:||...|.
  Rat   136 NDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYSLPESIGALLHLK 200

  Fly   161 AINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFF 225
            .:....|:|:.:...:.|.|  .|:.||::.|.|::|.:...|..|:..|.:..|.|.::||...
  Rat   201 DLWLDGNQLSELPQEIGNLR--NLLCLDVSENRLERLPEEISGLISLTDLVVSQNLLETVPDGIG 263

  Fly   226 AVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRI 290
            .:  .:|..|.:..|:|:.||                         |.:.:...|..|.|..||:
  Rat   264 KL--KKLSILKLDQNRLTQLP-------------------------EAIGDCENLTELVLTENRL 301

  Fly   291 GVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAM-LKVLDL 354
            ..||.: :....:|..|....|.|..||:|:.....|.|....:|.|...|.....|| |.|||:
  Rat   302 LTLPTS-IGKLKKLNNLNADRNKLVSLPKEIGGCCSLTVFCIRDNRLTRIPSEVSQAMELHVLDV 365

  Fly   355 SHNHLDRVNLLALVPSRNLKYLDLSGN-------LQLQVDEQQFK---------------VCQSQ 397
            :.|.|..:.|  .:.:..||.|.||.|       .|..||....:               :||..
  Rat   366 AGNRLHHLPL--SLTTLKLKALWLSDNQSQPLLTFQTDVDHTTGEKILTCVLLPQMPSEPICQES 428

  Fly   398 SQR---HWSLV-DVSGNNRAALPTTKIRQVSAQR--------NQNKTSGPWTMGFAETPGSGDCR 450
            ..|   ..||| |||   ..|.....:.:|||.|        .:|:|.   |:....||..|:.:
  Rat   429 LPRCGAMESLVNDVS---EEAWDDHSVHRVSAIRFLEDEKDEEENQTR---TLQRRATPHPGELK 487

  Fly   451 --KLSVYQLR 458
              |.:|..||
  Rat   488 NMKKTVENLR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/18 (28%)
		LRR_8	109..169	CDD:290566	16/70 (23%)
		leucine-rich repeat	111..135	CDD:275380	7/34 (21%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	8/24 (33%)
		LRR_8	205..266	CDD:290566	12/60 (20%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	47/180 (26%)
		leucine-rich repeat	256..276	CDD:275380	1/19 (5%)
		LRR_8	279..359	CDD:290566	26/80 (33%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	12/43 (28%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		PP2Cc	461..655	CDD:294085
Lrrc1	NP_001014290.1	LRR_RI	33..232	CDD:238064	38/162 (23%)
		leucine-rich repeat	38..60	CDD:275380
		LRR	39..412	CDD:227223	91/372 (24%)
		leucine-rich repeat	61..83	CDD:275380	2/4 (50%)
		leucine-rich repeat	84..106	CDD:275380	4/21 (19%)
		leucine-rich repeat	107..129	CDD:275380	5/21 (24%)
		leucine-rich repeat	130..152	CDD:275380	8/28 (29%)
		leucine-rich repeat	153..175	CDD:275380	2/21 (10%)
		leucine-rich repeat	176..198	CDD:275380	7/21 (33%)
		leucine-rich repeat	199..221	CDD:275380	5/23 (22%)
		leucine-rich repeat	222..244	CDD:275380	7/21 (33%)
		leucine-rich repeat	245..290	CDD:275380	12/71 (17%)
		leucine-rich repeat	314..336	CDD:275380	7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910