DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and conv

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001286416.1	Gene:	conv / 36588	FlyBaseID:	FBgn0261269	Length:	1092	Species:	Drosophila melanogaster

Alignment Length:	696	Identity:	163/696 - (23%)
Similarity:	261/696 - (37%)	Gaps:	185/696 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EEEQAATFGQTSPQKLSLKG-----SQLGGSILIGNYNYLTQL-EVCENEMEVLDLSSLAQLETL 94
            :|...||:.|.|...|:...     :..|..:|..:||.:|:: :.|        ...|.:|.|:
  Fly   410 DETTFATYFQLSYNNLTNLAQIPIQNMTGLKVLNASYNSITEIPKNC--------FPKLYELHTI 466

  Fly    95 KCSRNKLMELIINGT-----NLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWV- 153
            ..|.|.:.. |.||.     :|:::...||.:..|.::....:|..|: :|:|||   ||.:.|
  Fly   467 DVSHNNISS-IFNGVFQTLFSLRSIDLSHNSMREIKSSTFGTLPTLLE-MDLSHN---ELVSVVR 526

  Fly   154 GACASLTAINA-----------------------SHNRLNNV-----AVLLRNYRITELVSLDLA 190
            |:.|.||::..                       |||||.|:     .|:      ..|:.|||:
  Fly   527 GSLAKLTSLRQLYLNNNQLEKLFQLPISLNELYFSHNRLTNIPSGTWPVM------NSLIYLDLS 585

  Fly   191 YNDLKQL---DQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNN 252
            :|.|...   :.| .|...::.|:||:|.:...|.:..||. :.|:.|::..|.::||.|.....
  Fly   586 HNQLGDTLNGESF-TGLLVVQRLKLQNNGISQPPKDAVAVM-STLQYLHLENNNITTLERSAFGK 648

  Fly   253 HAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQL 317
            ...|..|:|.||.:.|..........:|..|:|:.|.|..|........|.|..|.||.|.|.:|
  Fly   649 LPVLFELNLYGNQVKDISKRAFEGLLQLLTLNLSSNGIQTLQNDIFVGLPSLRNLDLSFNSLTKL 713

  Fly   318 PEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSR-----NLKYLD 377
            ..:.            |.:      |..|..|:.||||||.:..|..... ||.     ||:.|:
  Fly   714 DNKT------------NGV------LDDLLSLETLDLSHNRISFVTKKTF-PSHQYIPYNLRNLN 759

  Fly   378 LSGNL----------------QLQVDEQQ-----------FKVCQS-----------QSQRH--- 401
            ||.||                :|.|...|           |...||           :|:.|
  Fly   760 LSYNLMPILTYDITFGTKKLVRLDVSHNQINDLRRGVISNFTSLQSLDMSYNELSNLKSEEHIFD 824

  Fly   402 ----WSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGS--GDCRKLSVYQLRAA 460
                .|.:|:|.|....||...:.:|.:.:..:.|:.    ...:.|.|  |..|..| ..|.|.
  Fly   825 LPQNLSWLDLSHNKIYHLPFANLVKVKSLKYVDLTNN----SLEDVPASIVGSMRNGS-QVLLAG 884

  Fly   461 N---YGGSDEAL-YGMFEALEGRGRAAQEMSHL---VPDLMKQEQMVKDSAVRDYMKFTLLAAQQ 518
            |   .|.:...| |.|.:    :..|.:::..:   .|.|:|.:|::  |...:|    |..|:.
  Fly   885 NPLHCGCNARPLKYFMLQ----QTIAGEDLKSIYCGTPALIKDKQLI--SLDDEY----LHCAED 939

  Fly   519 QCGSVRSAALFHLTRTRAPSKVRPLKSKR--------YVLRMASTGGLDAYLIRRTSQLRLTKPD 575
            :....:......||..|    .|.:|:.:        ||...:.......| ||.:|...|.:.|
  Fly   940 EQEMYKGIDYEQLTDVR----FREVKTNKAGMLTLCWYVSGFSDVSDFHVY-IRSSSNDVLHQSD 999

  Fly   576 VIQKDQIHSMPDPHVLEL-----------ILSNDDEYLVVGNAQLW 610
            ....::...:|...:..|           |:|.|.:    ||.:.|
  Fly  1000 YAYNNRTAQIPVEELSTLGEEKLRGAEICIVSRDSD----GNTRKW 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/23 (30%)
		LRR_8	109..169	CDD:290566	20/88 (23%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	9/22 (41%)
		leucine-rich repeat	159..183	CDD:275380	9/51 (18%)
		leucine-rich repeat	184..209	CDD:275380	8/27 (30%)
		LRR_8	205..266	CDD:290566	18/60 (30%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	51/203 (25%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	24/79 (30%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	10/43 (23%)
		leucine-rich repeat	349..372	CDD:275380	10/27 (37%)
		PP2Cc	461..655	CDD:294085	35/176 (20%)
conv	NP_001286416.1	leucine-rich repeat	125..148	CDD:275380
		leucine-rich repeat	150..175	CDD:275380
		leucine-rich repeat	176..199	CDD:275380
		LRR_8	198..258	CDD:290566
		leucine-rich repeat	200..223	CDD:275380
		LRR_RI	201..545	CDD:238064	37/147 (25%)
		leucine-rich repeat	224..271	CDD:275380
		LRR_8	245..306	CDD:290566
		leucine-rich repeat	272..295	CDD:275380
		LRR_8	296..354	CDD:290566
		leucine-rich repeat	296..319	CDD:275380
		LRR_8	322..401	CDD:290566
		leucine-rich repeat	322..343	CDD:275380
		leucine-rich repeat	344..367	CDD:275380
		leucine-rich repeat	371..390	CDD:275380
		leucine-rich repeat	391..414	CDD:275380	1/3 (33%)
		leucine-rich repeat	416..438	CDD:275380	4/21 (19%)
		LRR_8	437..495	CDD:290566	15/66 (23%)
		leucine-rich repeat	439..462	CDD:275380	6/30 (20%)
		leucine-rich repeat	463..486	CDD:275380	7/23 (30%)
		LRR_RI	486..738	CDD:238064	75/281 (27%)
		LRR_8	486..545	CDD:290566	17/62 (27%)
		leucine-rich repeat	487..510	CDD:275380	4/22 (18%)
		leucine-rich repeat	511..534	CDD:275380	11/26 (42%)
		leucine-rich repeat	535..554	CDD:275380	0/18 (0%)
		LRR_8	554..614	CDD:290566	19/66 (29%)
		leucine-rich repeat	555..578	CDD:275380	7/28 (25%)
		leucine-rich repeat	579..603	CDD:275380	8/24 (33%)
		leucine-rich repeat	604..627	CDD:275380	7/23 (30%)
		LRR_8	626..710	CDD:290566	24/83 (29%)
		leucine-rich repeat	628..649	CDD:275380	6/20 (30%)
		leucine-rich repeat	652..672	CDD:275380	6/19 (32%)
		LRR_8	698..765	CDD:290566	27/85 (32%)
		leucine-rich repeat	700..726	CDD:275380	10/43 (23%)
		leucine-rich repeat	727..745	CDD:275380	8/17 (47%)
		LRR_8	777..839	CDD:290566	12/61 (20%)
		leucine-rich repeat	779..802	CDD:275380	4/22 (18%)
		leucine-rich repeat	829..852	CDD:275380	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910