DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Lrfn1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001121166.1	Gene:	Lrfn1 / 365222	RGDID:	1304707	Length:	766	Species:	Rattus norvegicus

Alignment Length:	640	Identity:	130/640 - (20%)
Similarity:	209/640 - (32%)	Gaps:	193/640 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   231 RLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPA 295
            |:..|.::.|.::.:.|.:..|..:||:|:|:.|.:.........:...||.|||..||:..:..
  Rat    66 RVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDSNRLAEVRG 130

  Fly   296 ACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLD 360
            ..:|....|..|:|..|.::::  |.|...                  |.|:.::.||||:|:|:
  Rat   131 DQLRGLGNLRHLILGNNQIRKV--ESAAFD------------------AFLSTVEDLDLSYNNLE 175

  Fly   361 RVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLV--DVSGNNRAALPTTKIRQV 423
            .:...|:....||..|.|..||...:.|..|      .|.| .||  |::.|....||...: .:
  Rat   176 ALPWEAVGQMVNLNTLTLDHNLIDHIAEGTF------VQLH-KLVRLDMTSNRLHKLPPDGL-FL 232

  Fly   424 SAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQL------------------------------- 457
            .:|....|...|.|:.|...|...:|..|.:.:|
  Rat   233 RSQGGGPKPPTPLTVSFGGNPLHCNCELLWLRRLTREDDLETCATPEHLTDRYFWSIPEEEFLCE 297

  Fly   458 -----RAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSA------------- 504
                 |.|  ||  .||....:|:..|.||..:...:|..:....:::.:|:
  Rat   298 PPLITRQA--GG--RALVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLDVT 358

  Fly   505 ---VRDYMKFTLLAAQ---------QQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGG 557
               :||...||.:|:.         :.|  |....|........|....|..|.  :......|.
  Rat   359 ITTLRDSGTFTCIASNAAGEATAPVEVC--VVPLPLMAPPPAAPPPLTEPGSSD--IATPGRPGA 419

  Fly   558 LDAYLIRRTSQLRLTKPDVI---------------QKDQIHSMPDPHVLELILSNDDEYLV---- 603
            .|:...||.....||...|:               |.....|..|..|..:|.|....:||
  Rat   420 NDSATERRLVAAELTSSSVLIRWPAQRPVPGIRMYQVQYNSSADDSLVYRMIPSTSQTFLVNDLA 484

  Fly   604 VGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAES--------------------- 647
            .|.|       .|.....:..:..:.|.|.|:|...|...|.:.
  Rat   485 AGRA-------YDLCVLAVYDDGATALPATRVVGCVQFTTAGDPAPCRPLRAHFLGGTMIIAIGG 542

  Fly   648 ---------LSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRT---------- 693
                     :.::::|::..| |.|.  |.:|.:.|..|: ||      .||.:|
  Rat   543 VIVASVLVFIVLLMIRYKVYG-DGDS--RRIKGTSRSPPR-VS------HVCSQTNGSSAQQASA 597

  Fly   694 --CCDRSNACRHRAI----------------EQEPLAGRSSPSGQSDRDLLAKDK 730
              ..||..|.|..|:                |.|.:.|||.....:...||..::
  Rat   598 PPAPDRYEALREVAVPAAIEAKAMEAEATSTELEVVLGRSLGGSATSLCLLPSEE 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566	10/34 (29%)
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380	4/22 (18%)
		LRR_RI	<256..410	CDD:238064	41/155 (26%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	21/79 (27%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	8/43 (19%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		PP2Cc	461..655	CDD:294085	45/267 (17%)
Lrfn1	NP_001121166.1	LRR 1	66..87		4/20 (20%)
		leucine-rich repeat	67..90	CDD:275380	4/22 (18%)
		PPP1R42	70..226	CDD:411060	46/182 (25%)
		LRR 2	90..111		5/20 (25%)
		leucine-rich repeat	91..114	CDD:275380	5/22 (23%)
		LRR 3	114..135		7/20 (35%)
		leucine-rich repeat	115..138	CDD:275380	8/22 (36%)
		LRR 4	138..159		6/40 (15%)
		leucine-rich repeat	139..163	CDD:275380	8/43 (19%)
		LRR 5	163..184		7/20 (35%)
		leucine-rich repeat	164..187	CDD:275380	7/22 (32%)
		LRR 6	187..208		8/26 (31%)
		leucine-rich repeat	188..211	CDD:275380	9/29 (31%)
		LRR 7	211..232		6/21 (29%)
		leucine-rich repeat	212..230	CDD:275380	6/17 (35%)
		LRRCT	252..>284	CDD:214507	4/31 (13%)
		Ig	299..387	CDD:416386	18/93 (19%)
		Ig strand A	299..302	CDD:409353	0/2 (0%)
		Ig strand A'	306..310	CDD:409353	2/5 (40%)
		Ig strand B	316..324	CDD:409353	3/7 (43%)
		Ig strand C	330..335	CDD:409353	1/4 (25%)
		Ig strand C'	338..340	CDD:409353	0/1 (0%)
		Ig strand D	346..350	CDD:409353	0/3 (0%)
		Ig strand E	353..357	CDD:409353	0/3 (0%)
		Ig strand F	367..374	CDD:409353	3/6 (50%)
		Ig strand G	377..387	CDD:409353	1/11 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..422		4/26 (15%)
		FN3	426..500	CDD:238020	16/80 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..601		9/39 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..742		2/7 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000