DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and CG8272

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001260812.1	Gene:	CG8272 / 35875	FlyBaseID:	FBgn0033337	Length:	710	Species:	Drosophila melanogaster

Alignment Length:	687	Identity:	142/687 - (20%)
Similarity:	232/687 - (33%)	Gaps:	196/687 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 ILIGNYNYLTQLEV------CENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNY 120
            |::..::||...::      |:.....||.:...|...:..|:..|.:.:..|.:|  :..:..:
  Fly    18 IVLKIFSYLGYSDLQAAGSTCQRWHAALDQAEFNQRTRVCFSKVVLSDQLSPGVDL--MRCERRF 80

  Fly   121 LHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELV 185
            .|.:..             |::.....||..::|..|...|       |:||
  Fly    81 QHFLFE-------------DVTLGQVKELMRFMGRTAQSLA-------LDNV------------- 112

  Fly   186 SLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQ 250
              ||  || ||..........:.||.|: ..||......|      |::.|.||..|:.|    .
  Fly   113 --DL--ND-KQFYGMLGVLPHLHSLSLK-RCLPLFMSGSF------LDSYNNSCPDLNDL----A 161

  Fly   251 NNHAALVNLSLAGN-HLNDSI------FEPLHNAAKLRVLHLAYNRI-------------GVLPA 295
            :|.|.:..|:|..| :|.|:|      |.|...|..:...|:|::..             .|||:
  Fly   162 SNLAGIKELTLCENQYLTDAILMRLTSFMPSLEAINMSGCHIAFHNAIHRRFYPATSSSDHVLPS 226

  Fly   296 ACVRNWP-ELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHL 359
            ..|..:. .|.||.|....|:.|......:||..:..|..||.|....||....|....:
  Fly   227 ESVLTFKFILTILNLQRRTLRVLNFSHTLIGQALLALCDLNLQLQRLYLAGCRQLNCTTI----- 286

  Fly   360 DRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVD--VSGNNRAALPTTK--- 419
              :|.||..|  .|..||||..:.:. ||....:.|:..|.....|:  :|..|..|:...|
  Fly   287 --LNFLATQP--QLCALDLSATMCVN-DENLAALVQTNPQLEHLKVNGCLSITNAGAIHLAKLKC 346

  Fly   420 IRQVSAQRNQNKTSGPWTMGFA--ETPG-----------SGDCRKLSVYQLRA-----ANY---G 463
            ::.:......|.||.....|.|  |.|.           ..:|.|.....||.     .|:   |
  Fly   347 LKSLDISNCDNLTSSGIIEGIASEENPVIQELNVSYLQICEECIKAIASNLRCLRSLHLNHCVNG 411

  Fly   464 GSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAAL 528
            .:|||:    :::.|:.|..:|:|                             .:.|..:..|||
  Fly   412 ATDEAI----QSVIGQLRWLRELS-----------------------------LEHCSGLTDAAL 443

  Fly   529 -------FHLTRTRAPSKVR------PLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKD 580
                   ..::|.::.|:|.      |..|.....|.:..|.|.:..|    .||....|.|.:|
  Fly   444 TGINISKLEMSRKQSGSQVSSMDNFYPPYSNTLAERDSLAGSLQSIKI----SLRSKAEDEIVRD 504

  Fly   581 QIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAA 645
            ...........|:.|..:|::......||       |..|.:     :|....::.|::..:.
  Fly   505 ARRKQAMLAAYEMNLIREDDFEGHNIQQL-------RGLRSL-----NLRGCNKISDVSLKYG-- 555

  Fly   646 ESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSL 682
                     .:|:         ||::.:....|.:||
  Fly   556 ---------LKHI---------ELRRLMLSNCQQISL 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/18 (17%)
		LRR_8	109..169	CDD:290566	8/59 (14%)
		leucine-rich repeat	111..135	CDD:275380	2/23 (9%)
		leucine-rich repeat	136..158	CDD:275380	4/21 (19%)
		leucine-rich repeat	159..183	CDD:275380	4/23 (17%)
		leucine-rich repeat	184..209	CDD:275380	6/24 (25%)
		LRR_8	205..266	CDD:290566	17/61 (28%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		LRR_RI	<256..410	CDD:238064	45/176 (26%)
		leucine-rich repeat	256..276	CDD:275380	8/26 (31%)
		LRR_8	279..359	CDD:290566	21/93 (23%)
		leucine-rich repeat	280..303	CDD:275380	6/36 (17%)
		leucine-rich repeat	304..348	CDD:275380	14/43 (33%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	36/209 (17%)
CG8272	NP_001260812.1	AMN1	269..440	CDD:187754	43/213 (20%)
		leucine-rich repeat	270..295	CDD:275381	8/33 (24%)
		leucine-rich repeat	296..319	CDD:275381	8/23 (35%)
		leucine-rich repeat	322..346	CDD:275381	5/23 (22%)
		leucine-rich repeat	347..399	CDD:275381	10/51 (20%)
		leucine-rich repeat	400..426	CDD:275381	6/29 (21%)
		leucine-rich repeat	427..535	CDD:275381	25/147 (17%)
		AMN1	515..>642	CDD:187754	15/92 (16%)
		leucine-rich repeat	536..560	CDD:275381	4/48 (8%)
		leucine-rich repeat	561..586	CDD:275381	4/14 (29%)
		leucine-rich repeat	587..612	CDD:275381
		leucine-rich repeat	613..638	CDD:275381
		leucine-rich repeat	639..663	CDD:275381
		F-box-like	12..>44	CDD:289689	4/25 (16%)
		leucine-rich repeat	129..166	CDD:275381	13/47 (28%)
		leucine-rich repeat	167..192	CDD:275381	7/24 (29%)
		leucine-rich repeat	193..244	CDD:275381	11/50 (22%)
		C2	<231..274	CDD:301316	12/42 (29%)
		leucine-rich repeat	246..269	CDD:275381	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
	1	1.000