DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and CG4168

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001285953.1 Gene:CG4168 / 34889 FlyBaseID:FBgn0028888 Length:1330 Species:Drosophila melanogaster


Alignment Length:743 Identity:163/743 - (21%)
Similarity:281/743 - (37%) Gaps:184/743 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    67 YNYLTQLEVCENEMEVLD---LSSLAQLETLKCSRNKLMELIINGTN----LQTLVADHNYLHNI 124
            :::|.::::..|.:|.|:   ..||..|:||....|:|..:..:..:    |:.|...:|.|.||
  Fly   637 HSHLVEIDLSYNGLERLEAQTFHSLGDLQTLNLQSNRLRTIARHAFHNLEFLRYLDLSYNRLVNI 701

  Fly   125 STTNTHPVPLKLQRIDISHNNFSELP----NWVGACASLTAINASHNRLNNVAVLLRNYRITELV 185
            |......:| .|..:|:.||....|.    .:|....:...:|.|||.:.:....|.:|..  :.
  Fly   702 SHGAFTVLP-NLAALDLMHNQLCSLSLKSFLYVSNTTTPLRLNVSHNHIASFYDELSSYMY--IY 763

  Fly   186 SLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQ 250
            .||:::|.:.:.|.|....:::|.|.|..|:|.||..:.|..... ||.|||:.|.|::|.|...
  Fly   764 QLDISHNHVTKSDSFTNLANTLRFLNLAHNQLGSLQSHAFGDLEF-LEILNVAHNNLTSLRRRSF 827

  Fly   251 NNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQ 315
            ....:|..|.|:.|.|:....|...|..|||:|.:..||:..||.....| ..||.|.::.|.|.
  Fly   828 QGLNSLQELDLSHNQLDQLQVEQFSNLRKLRILRINSNRLRALPREVFMN-TRLEFLDIAENQLS 891

  Fly   316 QLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAM-LKVLDLSHNHLDRVNLLALVPSRNLKYLDLS 379
            ..|                     .|....:.. |:.:.:|||:|:.::....:.|:.|..:.|:
  Fly   892 VWP---------------------VPAFTDIGFTLRSIQMSHNNLEYLDASMFINSQFLYDISLA 935

  Fly   380 GNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETP 444
            .|....:.:..|....:.:.     :|:|.|   .|.||.:|:|                |..||
  Fly   936 RNRITILPDNTFSFLNNLTN-----LDLSQN---PLVTTNLREV----------------FVHTP 976

  Fly   445 GSGDCRKLSVYQLRAANYGGSDEALY-------GMFEALEGRGRAAQEMS--------------- 487
               ..||||::.:          .||       .:...|:..|...||:|               
  Fly   977 ---RLRKLSLHHM----------GLYVLPPLKLPLLSYLDVSGNYLQELSPLGSLRHLRHVNVSH 1028

  Fly   488 -----------HLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHL-----TRTRA 536
                       ||.|.:     .|.|.|.....:.||    ....|:|..|..::     |..:|
  Fly  1029 NKLTNASCAAEHLPPSV-----RVLDLAHNPLRRITL----HDLASLRHLAELNILDVKVTNPQA 1084

  Fly   537 PSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRL--TKPDVIQK--DQIHSMPDPHVLELILSN 597
            .||:|.|: |.:....|:.|.:.| .|....|||:  .:|::.|:  .::.:.....:|||..||
  Fly  1085 FSKLRSLR-KLHASSHANLGEIVA-RIPGLQQLRVHCLEPNIGQQLFAKLANNTKIRLLELYGSN 1147

  Fly   598 -----DDEYLVVGNAQ------------------LWSVMDIDRAAREIRKEENSLLAAKRLVDIA 639
                 .|.:..:..:|                  .:::.::...:.:|.....:.|||.......
  Fly  1148 VQTIAPDVFTGLSRSQRLQVKISHTRISDLPPGIFYALREVPHLSIDISHNRINALAADSFYPNK 1212

  Fly   640 QSFAAAESLSVI---------------VVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSV 689
            ..:.|..:.|::               :|.|.|      .|.|.|::|.:.|      .:....:
  Fly  1213 SYWDAVGTRSIMGGLITSHNPLECECGLVWFGH------WLRRWLRESAQIK------VIQKDDL 1265

  Fly   690 CKRTCCDRSNACRHRAIEQEPLAGRSSP 717
            .:.....|:|.|      .:|.:||..|
  Fly  1266 KRMVQRARANTC------HDPTSGRHLP 1287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 5/18 (28%)
LRR_8 109..169 CDD:290566 18/67 (27%)
leucine-rich repeat 111..135 CDD:275380 8/23 (35%)
leucine-rich repeat 136..158 CDD:275380 6/25 (24%)
leucine-rich repeat 159..183 CDD:275380 6/23 (26%)
leucine-rich repeat 184..209 CDD:275380 5/24 (21%)
LRR_8 205..266 CDD:290566 21/60 (35%)
leucine-rich repeat 210..230 CDD:275380 7/19 (37%)
leucine-rich repeat 232..255 CDD:275380 9/22 (41%)
LRR_RI <256..410 CDD:238064 35/154 (23%)
leucine-rich repeat 256..276 CDD:275380 6/19 (32%)
LRR_8 279..359 CDD:290566 20/80 (25%)
leucine-rich repeat 280..303 CDD:275380 8/22 (36%)
leucine-rich repeat 304..348 CDD:275380 7/43 (16%)
leucine-rich repeat 349..372 CDD:275380 6/22 (27%)
PP2Cc 461..655 CDD:294085 48/273 (18%)
CG4168NP_001285953.1 leucine-rich repeat 99..118 CDD:275380
LRR_8 121..181 CDD:290566
LRR_RI 122..350 CDD:238064
leucine-rich repeat 122..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..194 CDD:275380
leucine-rich repeat 195..214 CDD:275380
leucine-rich repeat 215..236 CDD:275380
LRR_8 265..322 CDD:290566
leucine-rich repeat 266..287 CDD:275380
leucine-rich repeat 288..311 CDD:275380
leucine-rich repeat 312..338 CDD:275380
LRR_RI 315..546 CDD:238064
leucine-rich repeat 339..365 CDD:275380
LRR_8 365..424 CDD:290566
leucine-rich repeat 366..388 CDD:275380
leucine-rich repeat 389..412 CDD:275380
LRR_8 413..470 CDD:290566
leucine-rich repeat 414..436 CDD:275380
leucine-rich repeat 437..459 CDD:275380
leucine-rich repeat 460..483 CDD:275380
LRR_8 482..545 CDD:290566
leucine-rich repeat 484..510 CDD:275380
leucine-rich repeat 511..534 CDD:275380
leucine-rich repeat 535..589 CDD:275380
LRR_RI 588..891 CDD:238064 73/258 (28%)
LRR_8 588..650 CDD:290566 2/12 (17%)
leucine-rich repeat 590..613 CDD:275380
leucine-rich repeat 614..639 CDD:275380 0/1 (0%)
LRR_8 638..698 CDD:290566 14/59 (24%)
leucine-rich repeat 640..663 CDD:275380 6/22 (27%)
leucine-rich repeat 664..687 CDD:275380 5/22 (23%)
LRR_8 688..749 CDD:290566 18/61 (30%)
leucine-rich repeat 688..711 CDD:275380 8/23 (35%)
leucine-rich repeat 712..735 CDD:275380 6/22 (27%)
leucine-rich repeat 740..783 CDD:275380 11/44 (25%)
LRR_8 784..843 CDD:290566 21/59 (36%)
leucine-rich repeat 785..808 CDD:275380 8/22 (36%)
leucine-rich repeat 809..832 CDD:275380 9/22 (41%)
LRR_RI <827..1053 CDD:238064 61/289 (21%)
LRR_8 832..890 CDD:290566 20/58 (34%)
leucine-rich repeat 833..856 CDD:275380 7/22 (32%)
leucine-rich repeat 857..879 CDD:275380 8/22 (36%)
leucine-rich repeat 880..900 CDD:275380 7/40 (18%)
LRR_8 904..963 CDD:290566 13/66 (20%)
leucine-rich repeat 905..928 CDD:275380 6/22 (27%)
leucine-rich repeat 929..952 CDD:275380 4/22 (18%)
leucine-rich repeat 953..977 CDD:275380 11/50 (22%)
leucine-rich repeat 978..1020 CDD:275380 11/51 (22%)
LRR_8 1019..1074 CDD:290566 11/63 (17%)
leucine-rich repeat 1045..1068 CDD:275380 6/31 (19%)
leucine-rich repeat 1069..1090 CDD:275380 5/20 (25%)
leucine-rich repeat 1091..1114 CDD:275380 6/24 (25%)
leucine-rich repeat 1115..1161 CDD:275380 10/45 (22%)
leucine-rich repeat 1162..1190 CDD:275380 1/27 (4%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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