DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and LRRTM3

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_821079.3	Gene:	LRRTM3 / 347731	HGNCID:	19410	Length:	581	Species:	Homo sapiens

Alignment Length:	500	Identity:	121/500 - (24%)
Similarity:	191/500 - (38%)	Gaps:	141/500 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 CENEMEVLDLSSLAQLET--------LKCSRNKLMELIIN---GTN-LQTLVADHNYLHNISTTN 128
            ||.:|...:...|.::.:        |....|.|.:|..|   |.| |..|..|||::.||....
Human    40 CEGKMVYCESQKLQEIPSSISAGCLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENA 104

  Fly   129 THPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYR-ITELVSLDLAYN 192
            .:.: .:|:.:.:|.|..|..                   |||      .:| :|.|.:|||:||
Human   105 FNGI-RRLKELILSSNRISYF-------------------LNN------TFRPVTNLRNLDLSYN 143

  Fly   193 DLKQL--DQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAA 255
            .|..|  :|| .|...:.||.|:||.|.::|...|.... .||.|::..|::.:|.|   |..|.
Human   144 QLHSLGSEQF-RGLRKLLSLHLRSNSLRTIPVRIFQDCR-NLELLDLGYNRIRSLAR---NVFAG 203

  Fly   256 LVNLSLAGNHLNDSIFEPLHNA-----AKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQ 315
            ::.|...  ||..:.|..|:.|     ..|:.|:|.:|:|.|:.......|..|:.|.||||
Human   204 MIRLKEL--HLEHNQFSKLNLALFPRLVSLQNLYLQWNKISVIGQTMSWTWSSLQRLDLSGN--- 263

  Fly   316 QLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSG 380
                |:.......|.:|..|             |:.|:|..|.|..:....|....:|..:.|:|
Human   264 ----EIEAFSGPSVFQCVPN-------------LQRLNLDSNKLTFIGQEILDSWISLNDISLAG 311

  Fly   381 NL--------QLQVDEQQFK-------VCQSQSQ----------RHWSLVDVSGNNR----AALP 416
            |:        .|....:.||       :|.|..:          :::|:...|...|    .|||
Human   312 NIWECSRNICSLVNWLKSFKGLRENTIICASPKELQGVNVIDAVKNYSICGKSTTERFDLARALP 376

  Fly   417 TTKIR-QVSAQRNQNKTSGPWTMGFAETPG---SGDCRKLSVYQLRAANYGGSDEALYGMFEALE 477
            ....: ::...::::|...|.|:|..| ||   ..|...:|.:::.|
Human   377 KPTFKPKLPRPKHESKPPLPPTVGATE-PGPETDADAEHISFHKIIA------------------ 422

  Fly   478 GRGRAAQEMSHLV------------PDLMKQEQMVKDSAVRDYMK 510
              |..|..:|.||            |..|||.|  :.|.:|.:.|
Human   423 --GSVALFLSVLVILLVIYVSWKRYPASMKQLQ--QRSLMRRHRK 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/29 (21%)
		LRR_8	109..169	CDD:290566	12/60 (20%)
		leucine-rich repeat	111..135	CDD:275380	7/23 (30%)
		leucine-rich repeat	136..158	CDD:275380	4/21 (19%)
		leucine-rich repeat	159..183	CDD:275380	4/24 (17%)
		leucine-rich repeat	184..209	CDD:275380	11/26 (42%)
		LRR_8	205..266	CDD:290566	17/60 (28%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		LRR_RI	<256..410	CDD:238064	40/183 (22%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	21/79 (27%)
		leucine-rich repeat	280..303	CDD:275380	7/22 (32%)
		leucine-rich repeat	304..348	CDD:275380	10/43 (23%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085	12/61 (20%)
LRRTM3	NP_821079.3	LRRNT	33..61	CDD:214470	4/20 (20%)
		LRR 1	63..83		5/19 (26%)
		leucine-rich repeat	66..86	CDD:275380	6/19 (32%)
		LRR_8	86..145	CDD:404697	22/84 (26%)
		LRR 2	86..107		7/20 (35%)
		leucine-rich repeat	87..110	CDD:275380	7/23 (30%)
		LRR 3	110..131		7/45 (16%)
		leucine-rich repeat	111..134	CDD:275380	8/47 (17%)
		LRR 4	134..155		10/21 (48%)
		leucine-rich repeat	135..158	CDD:275380	11/23 (48%)
		PPP1R42	156..342	CDD:411060	53/211 (25%)
		LRR 5	158..179		8/20 (40%)
		leucine-rich repeat	159..182	CDD:275380	8/23 (35%)
		LRR 6	182..203		7/23 (30%)
		leucine-rich repeat	183..206	CDD:275380	8/25 (32%)
		LRR 7	206..226		6/21 (29%)
		leucine-rich repeat	207..230	CDD:275380	6/24 (25%)
		LRR 8	230..251		6/20 (30%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		LRR 9	254..275		8/27 (30%)
		leucine-rich repeat	255..279	CDD:275380	9/30 (30%)
		LRR 10	279..300		7/33 (21%)
		leucine-rich repeat	280..300	CDD:275380	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..408		7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910