DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Gyc32E

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001097148.1	Gene:	Gyc32E / 34553	FlyBaseID:	FBgn0010197	Length:	1191	Species:	Drosophila melanogaster

Alignment Length:	805	Identity:	150/805 - (18%)
Similarity:	250/805 - (31%)	Gaps:	302/805 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 SHNRLNNVAVLLRNYRITELVSLD--LAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAV 227
            |:.|:|   ::.|||       ||  :.....|.||:.  .|.|:..:.:...:.|.:.|
  Fly   281 SNRRVN---IMERNY-------LDPYIRKEKSKSLDKI--SFRSVIKISMTYPQNPHIRD----- 328

  Fly   228 THARLETLNVSCNKLSTLPR-------YEQ---NNHAALVNLSLAGNHLNDSIFEPLHNAAKLRV 282
                      .|:|:....|       |.|   :|    :::.:.|.||.||:.  ::..|...|
  Fly   329 ----------ICSKIKDYARKTPFLVPYHQRVFDN----ISVPIYGLHLYDSVM--IYVRAITEV 377

  Fly   283 LHLA---YNRIGVLPAACVRNWPEL---EILVLS-----GN----MLQQLPEEVATLGQL----- 327
            |.|.   |:...|:.....|::..:   ::.:.|     ||    .||......|::|.|
  Fly   378 LRLGGDIYDGNLVMSHIFNRSYHSIQGFDVYIDSNGDAEGNYTVITLQNDVGSGASIGSLAKMSM 442

  Fly   328 -----------------------RVLRCCNNLLLCTPQLA--------KLAMLKVLD-------- 353
                                   |.::..|.    .|.||        :|...|.||
  Fly   443 QPVGFFAYDKNSVIPEFRYIKNDRPIQWLNG----RPPLAEPLCGFHGELCPRKKLDWRYLVSGP 503

  Fly   354 -------------LSHNHLDR--VNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQ------ 397
                         :.|...::  ..||..|..:::..::| |......::..|::|:..
  Fly   504 LCALVVVVAIALLIKHYRYEQTLAGLLWKVDMKDVTVINL-GEYNNPTNKNIFQICRQSILVVGE 567

  Fly   398 -SQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAAN 461
             ::|.::.:.:...|..|:.....:.|...|:..|          |.....:.|..::.....|:
  Fly   568 PNKRSFTNIALFRGNIVAMKKIHKKSVDITRSIRK----------ELKLMREVRHENIINFIGAS 622

  Fly   462 YGGSDEALYGMFEALEGRGR----AAQE--------MSHLVPDLMKQEQMVKDSAVRDYMKFTLL 514
               :|.....:|.....||.    .|.|        :|.||.|::|....:.||.:..:
  Fly   623 ---TDHGSVIIFTTYCARGSLEDVLANEDLHLDHMFISSLVSDILKGMIYLHDSEIISH------ 678

  Fly   515 AAQQQCGSVRSA------------ALFHLTRTRA----PSKVRPLKSKRYVLRMASTGGLDAYLI 563
                  |::||:            :.|.|...:|    |:| ..|:.|| .|.||.....|||..
  Fly   679 ------GNLRSSNCLIDSRWVCQISDFGLHELKAGQEEPNK-SELELKR-ALCMAPELLRDAYRP 735

  Fly   564 RRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENS 628
            .|.||    |.||            :...::|     |.::|....|.    |.|   ..|||
  Fly   736 GRGSQ----KGDV------------YSFGILL-----YEMIGRKGPWG----DTA---YSKEE-- 770

  Fly   629 LLAAKRLVDIAQSFAAAESLSVIVVR--FRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCK 691
                     |.|.....|.|...|.|  ..|...|:...||:                     |.
  Fly   771 ---------IIQFVKCPEMLQHGVFRPALTHTHLDIPDYIRK---------------------CL 805

  Fly   692 RTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEMLDETES 756
            ..|.|.....|                           .|...|..|.:.||...:..:.|...|
  Fly   806 CQCWDEDPEVR---------------------------PDIRLVRMHLKELQAGLKPNIFDNMLS 843

  Fly   757 VSESVLSEEQFKCWEYMLE----QNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERNDFTS 817
            :.|.         :.|.||    :.|.||::::..|   .....:.:|..:  |.:|...:...:
  Fly   844 IMEK---------YAYNLEGLVQERTNLLYEEKKKT---DMLLYQMLPRPV--AELLKRGDPVEA 894

  Fly   818 NLMRTVT---------NKFISTSTP 833
            .....||         .:..:||||
  Fly   895 ECFDCVTILFSDIVGFTELCTTSTP 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	1/3 (33%)
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380	6/17 (35%)
		leucine-rich repeat	184..209	CDD:275380	7/26 (27%)
		LRR_8	205..266	CDD:290566	10/70 (14%)
		leucine-rich repeat	210..230	CDD:275380	2/19 (11%)
		leucine-rich repeat	232..255	CDD:275380	6/32 (19%)
		LRR_RI	<256..410	CDD:238064	38/234 (16%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	24/151 (16%)
		leucine-rich repeat	280..303	CDD:275380	6/25 (24%)
		leucine-rich repeat	304..348	CDD:275380	14/91 (15%)
		leucine-rich repeat	349..372	CDD:275380	7/45 (16%)
		PP2Cc	461..655	CDD:294085	51/223 (23%)
Gyc32E	NP_001097148.1	PBP1_Speract_GC_like	44..448	CDD:107365	41/199 (21%)
		ANF_receptor	59..427	CDD:279440	38/178 (21%)
		PHA02988	534..826	CDD:165291	74/406 (18%)
		PK_GC-A_B	550..832	CDD:270944	75/395 (19%)
		HNOBA	<847..886	CDD:285003	9/52 (17%)
		CYCc	865..1057	CDD:214485	10/60 (17%)
		Guanylate_cyc	892..1076	CDD:278633	6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900