DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and LRRIQ4

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001073929.1 Gene:LRRIQ4 / 344657 HGNCID:34298 Length:560 Species:Homo sapiens


Alignment Length:360 Identity:105/360 - (29%)
Similarity:160/360 - (44%) Gaps:54/360 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 YLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMEL---IINGTNLQTLVADHNYLHNISTTNTH 130
            |.|.|:    |:.|:...:|..||.|..:.|.|..|   |:|.|.|:.:....|..      ...
Human   126 YQTDLK----EIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQF------EVF 180

  Fly   131 PVPL----KLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNY-RITELVSLDLA 190
            |..|    .|:.||:..|....:|..:|   .||.:...:...||:.||..:. :.::|..|||:
Human   181 PQELCVLYTLEIIDLDENKIGAIPEEIG---HLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLS 242

  Fly   191 YNDLKQLDQFPEGFSSIRSLQ---LQSNELPSLPDNFFAVTHARLETL-NVSCNKLSTLPRYEQN 251
            :|   .|...|:.|:.:|.:.   |..|.|..:|......|...|..| |...::|       :.
Human   243 HN---LLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRL-------RG 297

  Fly   252 NHAALVN---LSLAGNHLNDSIFEPLHNAA--KLRVLHLAYNRIGVLPAACVRNWPELEILVLSG 311
            :...|||   |.|:.|||:..   ||...|  .|.||.|..|:||.||:. :.:..:|:||.|:|
Human   298 SFRCLVNLRFLDLSQNHLHHC---PLQICALKNLEVLGLDDNKIGQLPSE-LGSLSKLKILGLTG 358

  Fly   312 NMLQQLPEEVATLGQLRVLRCCNN----LLLCTPQLAKLAMLKVLDLSHNHLDRVNL-LALVPSR 371
            |.....||||.:|..|..|....:    |......:.||..||.|.:.:|||:.:.: |..:|  
Human   359 NEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMP-- 421

  Fly   372 NLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVD 406
            ||:.||...||..|:.:   .:||:|:.:...|.|
Human   422 NLEVLDCRHNLLKQLPD---AICQAQALKELRLED 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 8/21 (38%)
LRR_8 109..169 CDD:290566 13/63 (21%)
leucine-rich repeat 111..135 CDD:275380 4/27 (15%)
leucine-rich repeat 136..158 CDD:275380 6/21 (29%)
leucine-rich repeat 159..183 CDD:275380 6/24 (25%)
leucine-rich repeat 184..209 CDD:275380 8/24 (33%)
LRR_8 205..266 CDD:290566 16/67 (24%)
leucine-rich repeat 210..230 CDD:275380 5/22 (23%)
leucine-rich repeat 232..255 CDD:275380 4/23 (17%)
LRR_RI <256..410 CDD:238064 56/161 (35%)
leucine-rich repeat 256..276 CDD:275380 10/22 (45%)
LRR_8 279..359 CDD:290566 29/83 (35%)
leucine-rich repeat 280..303 CDD:275380 9/22 (41%)
leucine-rich repeat 304..348 CDD:275380 16/47 (34%)
leucine-rich repeat 349..372 CDD:275380 8/23 (35%)
PP2Cc 461..655 CDD:294085
LRRIQ4NP_001073929.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
LRR 1 23..47
LRR 2 48..70
leucine-rich repeat 50..72 CDD:275380
LRR 3 72..95
leucine-rich repeat 73..119 CDD:275380
LRR 4 97..116
LRR_RI 117..360 CDD:238064 74/260 (28%)
LRR 5 117..140 5/17 (29%)
LRR_8 120..177 CDD:290566 17/54 (31%)
leucine-rich repeat 120..143 CDD:275380 6/20 (30%)
LRR 6 141..164 8/22 (36%)
leucine-rich repeat 144..166 CDD:275380 8/21 (38%)
LRR 7 166..187 4/26 (15%)
leucine-rich repeat 167..189 CDD:275380 4/27 (15%)
LRR 8 188..210 6/24 (25%)
LRR_8 189..246 CDD:290566 17/62 (27%)
leucine-rich repeat 190..212 CDD:275380 7/24 (29%)
LRR 9 212..233 4/20 (20%)
leucine-rich repeat 213..235 CDD:275380 4/21 (19%)
LRR_8 234..315 CDD:290566 24/90 (27%)
LRR 10 234..256 8/24 (33%)
leucine-rich repeat 236..258 CDD:275380 8/24 (33%)
LRR_RI 253..501 CDD:238064 67/217 (31%)
LRR 11 258..281 4/22 (18%)
leucine-rich repeat 259..304 CDD:275380 10/51 (20%)
LRR 12 283..301 4/24 (17%)
LRR 13 302..325 10/25 (40%)
leucine-rich repeat 305..327 CDD:275380 8/24 (33%)
LRR 14 326..348 9/22 (41%)
leucine-rich repeat 328..350 CDD:275380 9/22 (41%)
LRR 15 350..371 10/20 (50%)
leucine-rich repeat 351..370 CDD:275380 10/18 (56%)
leucine-rich repeat 374..399 CDD:275380 5/24 (21%)
LRR 16 374..397 3/22 (14%)
LRR 17 398..422 8/25 (32%)
LRR_8 399..456 CDD:290566 20/60 (33%)
leucine-rich repeat 400..422 CDD:275380 8/23 (35%)
leucine-rich repeat 423..445 CDD:275380 8/24 (33%)
LRR 18 424..443 6/21 (29%)
LRR 19 444..466 3/10 (30%)
leucine-rich repeat 446..468 CDD:275380 2/8 (25%)
LRR 20 468..489
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 529..560
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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