DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and fliI

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_525097.1	Gene:	fliI / 33110	FlyBaseID:	FBgn0000709	Length:	1256	Species:	Drosophila melanogaster

Alignment Length:	593	Identity:	148/593 - (24%)
Similarity:	252/593 - (42%)	Gaps:	129/593 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VTAAEEEQAATFGQTSPQK-----LSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQL 91
            |...:.:.:|||..:..|.     |:|..:||.              |:.|      :|..|.:|
  Fly    10 VDFTKNDFSATFPSSMRQMSRVQWLTLDRTQLA--------------EIPE------ELGHLQKL 54

  Fly    92 ETLKCSRNKLMELIINGTN---LQTLVADHNYLHNISTTNTHPVPL----KLQRIDISHNNFSEL 149
            |.|..:.|:|.::....|.   |::|...||.|.|...    |..|    :|..:|:|||...|:
  Fly    55 EHLSLNHNRLEKIFGELTELSCLRSLDLRHNQLKNSGI----PPELFHLEELTTLDLSHNKLKEV 115

  Fly   150 PNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQS 214
            |..:....:|..:|.|:|::.::...| ...:|:|:.|||::|.|:.|........::::|.|..
  Fly   116 PEGLERAKNLIVLNLSNNQIESIPTPL-FIHLTDLLFLDLSHNRLETLPPQTRRLINLKTLDLSH 179

  Fly   215 N--------ELPSL------------------PDNFFAVTHARLETLNVSCNKLSTLPR--YEQN 251
            |        :||||                  |.:..::  |.|..|::|.|.|..||.  |
  Fly   180 NPLELFQLRQLPSLQSLEVLKMSGTQRTLLNFPTSIDSL--ANLCELDLSHNSLPKLPDCVY--- 239

  Fly   252 NHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNML-- 314
            |...||.|:|:.|.|.: :...:....:|..|:|:.|::..||||..: .|:|..|:::.|.|
  Fly   240 NVVTLVRLNLSDNELTE-LTAGVELWQRLESLNLSRNQLVALPAALCK-LPKLRRLLVNDNKLNF 302

  Fly   315 QQLPEEVATLGQLRVLRCCNNLLLCTPQ-LAKLAMLKVLDLSHNHL----DRVNLLALVPSRNLK 374
            :.:|..:..||.|.|....||||...|: |.:...||.|:||.|.|    |.::||     ..|.
  Fly   303 EGIPSGIGKLGALEVFSAANNLLEMVPEGLCRCGALKQLNLSCNRLITLPDAIHLL-----EGLD 362

  Fly   375 YLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMG 439
            .|||..|.:|.:..:..:..::.|...:: :|.|       ..|::|...|       :.|.:|.
  Fly   363 QLDLRNNPELVMPPKPSEASKATSLEFYN-IDFS-------LQTQLRLAGA-------AVPPSMP 412

  Fly   440 FAETPGSGDCRKLSVYQLRAA--NYGGSDEA--LYGMFEALEGRGRAAQEMSHLVPDLMKQEQMV 500
            .:.||.....||:   :||..  :.|..|.|  |.||.:..:.:...|    ..||:..|.|.:.
  Fly   413 SSATPKDSTARKI---RLRRGPRSEGDQDAAKVLKGMKDVAKDKDNEA----GAVPEDGKPESLK 470

  Fly   501 K---DSAVR----DYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGL 558
            .   |.::.    ||.||    .::..|.:....::.: ....|:|:..:...::.     .|
  Fly   471 PKRWDESLEKPQLDYSKF----FEKDDGQLPGLTIWEI-ENFLPNKIEEVVHGKFY-----EG-- 523

  Fly   559 DAYLIRRT 566
            |.|::.:|
  Fly   524 DCYIVLKT 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	5/18 (28%)
		LRR_8	109..169	CDD:290566	20/66 (30%)
		leucine-rich repeat	111..135	CDD:275380	8/27 (30%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	7/24 (29%)
		LRR_8	205..266	CDD:290566	23/88 (26%)
		leucine-rich repeat	210..230	CDD:275380	8/45 (18%)
		leucine-rich repeat	232..255	CDD:275380	9/24 (38%)
		LRR_RI	<256..410	CDD:238064	49/160 (31%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	30/82 (37%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	15/46 (33%)
		leucine-rich repeat	349..372	CDD:275380	10/26 (38%)
		PP2Cc	461..655	CDD:294085	23/115 (20%)
fliI	NP_525097.1	leucine-rich repeat	7..30	CDD:275380	5/19 (26%)
		leucine-rich repeat	31..53	CDD:275380	8/41 (20%)
		LRR_8	53..112	CDD:290566	19/62 (31%)
		leucine-rich repeat	54..76	CDD:275380	6/21 (29%)
		LRR_RI	70..304	CDD:238064	66/245 (27%)
		leucine-rich repeat	77..101	CDD:275380	8/27 (30%)
		LRR_8	101..159	CDD:290566	18/58 (31%)
		leucine-rich repeat	102..124	CDD:275380	7/21 (33%)
		leucine-rich repeat	125..148	CDD:275380	5/23 (22%)
		leucine-rich repeat	149..171	CDD:275380	7/21 (33%)
		LRR_8	152..231	CDD:290566	19/80 (24%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		leucine-rich repeat	196..220	CDD:275380	1/25 (4%)
		leucine-rich repeat	221..243	CDD:275380	9/24 (38%)
		LRR_8	243..300	CDD:290566	18/58 (31%)
		leucine-rich repeat	244..266	CDD:275380	6/22 (27%)
		leucine-rich repeat	267..289	CDD:275380	8/22 (36%)
		leucine-rich repeat	290..314	CDD:275380	6/23 (26%)
		LRR_8	315..370	CDD:290566	22/59 (37%)
		leucine-rich repeat	315..335	CDD:275380	8/19 (42%)
		leucine-rich repeat	338..360	CDD:275378	10/26 (38%)
		gelsolin_S1_like	491..602	CDD:200446	7/49 (14%)
		gelsolin_like	618..706	CDD:200436
		gelsolin_S3_like	729..828	CDD:200448
		gelsolin_like	920..1015	CDD:200436
		gelsolin_S5_like	1037..1141	CDD:200444
		gelsolin_S6_like	1151..1250	CDD:200447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910