DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Lgr6

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001028581.1 Gene:Lgr6 / 329252 MGIID:2441805 Length:967 Species:Mus musculus


Alignment Length:855 Identity:185/855 - (21%)
Similarity:296/855 - (34%) Gaps:243/855 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 QKLSLKGSQLG---GSILIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSR--NKLMELI--- 105
            ::|.|.|:.|.   |....|.:: |..|.:..|::..:...:|.:|.:|:..|  ..|:.|:   
Mouse    93 EELRLSGNHLSHIPGQAFSGLHS-LKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPER 156

  Fly   106 -ING-TNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASH-- 166
             ..| ::|:.|..|.|.|..|.....:.:| .||.:.::.|:...:|::  |..:||::...|  
Mouse   157 SFEGLSSLRHLWLDDNALTEIPVRALNNLP-ALQAMTLALNHIRHIPDY--AFQNLTSLVVLHLH 218

  Fly   167 -NRLNNVAVLLRNYR-ITELVSLDLAYNDLKQLDQFPEGFSSIRSLQ---LQSNELPSLPDNFFA 226
             ||:.:|..  .::. :..|.:|||.||:|:   :||....::..||   ..:|.:.::|:..| 
Mouse   219 NNRIQHVGT--HSFEGLHNLETLDLNYNELQ---EFPLAIRTLGRLQELGFHNNNIKAIPEKAF- 277

  Fly   227 VTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAG-NHLNDSIFEPLHNAAKLRVLHLAYNRI 290
            :....|:|::...|.:..:.|......:.|..|||.| ..:.:  |..|.....|.:|.|....|
Mouse   278 MGSPLLQTIHFYDNPIQFVGRSAFQYLSKLHTLSLNGATDIQE--FPDLKGTTSLEILTLTRAGI 340

  Fly   291 GVLPAACVRNWPELEILVLSGNMLQQLP--------EEV---------------ATLGQLRVLRC 332
            .:||....:..|.|.||.||.|.:::||        ||:               :.||.|:.|..
Mouse   341 RLLPPGVCQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDL 405

  Fly   333 C-NNLLLCTPQ-LAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFK--- 392
            . |.:....|: .:.|..|..|||:.|.|..:.|..|   ..|.:|.|.|||.|   .|.|.   
Mouse   406 SWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGL---GGLMHLKLKGNLAL---SQAFSKDS 464

  Fly   393 -------------------VCQS--QSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQ------- 429
                               :|.|  ::...|...|.......| |...:..::.|...       
Mouse   465 FPKLRILEVPYAYQCCAYGICASFFKTSGQWQAEDFHPEEEEA-PKRPLGLLAGQAENHYDLDLD 528

  Fly   430 -----------------NKTSGP-----------------WTM--------------GFAETPGS 446
                             :...||                 |.:              .||..|..
Mouse   529 ELQMGTEDSKPHPSVQCSPVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLLTVFASGPSP 593

  Fly   447 GDCRKLSVYQLRAAN---------YGGSDEALYGMFEALEGR---GRAAQ----------EMSHL 489
            ....||.|..:..||         ....|...||.|.....|   |...|          |.|.|
Mouse   594 LSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLGCQATGFLAVLGSEASVL 658

  Fly   490 VPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMAS 554
            :..|...:..:..:.||.|.|      ....||||:.||..|.          |......|.:||
Mouse   659 LLTLAAVQCSISVTCVRAYGK------APSPGSVRAGALGCLA----------LAGLAAALPLAS 707

  Fly   555 TGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPD--PHVL----ELILSNDDEYLVVGNAQLWSVM 613
            .|...|      |.|.|.          ::.|:  |..|    .|::.|...:|||..|.:....
Mouse   708 VGEYGA------SPLCLP----------YAPPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYC 756

  Fly   614 DIDRAARE------IRKEENSLLAAKRLVDIAQSFAAAESL------------SVIVVRF----- 655
            |:.|...|      :.:....|:.|..|:....:|.:..|:            ||::|..     
Mouse   757 DLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPAC 821

  Fly   656 ----------RHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEP 710
                      .|...|    :|.|..|.|   .|..|..::....:::.||.:.|.  .|.....
Mouse   822 LNPLLYLLFNPHFRDD----LRRLWPSPR---SPGPLAYAAAGELEKSSCDSTQAL--VAFSDVD 877

  Fly   711 LAGRSSPSGQ 720
            |...:|.:||
Mouse   878 LILEASEAGQ 887

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 6/25 (24%)
LRR_8 109..169 CDD:290566 16/62 (26%)
leucine-rich repeat 111..135 CDD:275380 7/23 (30%)
leucine-rich repeat 136..158 CDD:275380 5/21 (24%)
leucine-rich repeat 159..183 CDD:275380 6/27 (22%)
leucine-rich repeat 184..209 CDD:275380 9/24 (38%)
LRR_8 205..266 CDD:290566 14/64 (22%)
leucine-rich repeat 210..230 CDD:275380 5/22 (23%)
leucine-rich repeat 232..255 CDD:275380 4/22 (18%)
LRR_RI <256..410 CDD:238064 52/203 (26%)
leucine-rich repeat 256..276 CDD:275380 7/20 (35%)
LRR_8 279..359 CDD:290566 29/104 (28%)
leucine-rich repeat 280..303 CDD:275380 6/22 (27%)
leucine-rich repeat 304..348 CDD:275380 17/68 (25%)
leucine-rich repeat 349..372 CDD:275380 8/22 (36%)
PP2Cc 461..655 CDD:294085 52/239 (22%)
Lgr6NP_001028581.1 LRRNT 34..68 CDD:214470
LRR_4 70..107 CDD:289563 4/13 (31%)
leucine-rich repeat 70..91 CDD:275380
LRR 1 91..112 5/18 (28%)
LRR_8 92..150 CDD:290566 13/57 (23%)
LRR_4 92..131 CDD:289563 9/38 (24%)
leucine-rich repeat 92..115 CDD:275380 6/21 (29%)
LRR 2 115..136 4/21 (19%)
leucine-rich repeat 116..139 CDD:275380 5/22 (23%)
LRR_8 138..198 CDD:290566 15/60 (25%)
LRR 3 139..160 4/20 (20%)
leucine-rich repeat 140..163 CDD:275380 5/22 (23%)
LRR_RI 143..392 CDD:238064 64/259 (25%)
LRR 4 163..186 6/22 (27%)
leucine-rich repeat 164..187 CDD:275380 7/23 (30%)
LRR_8 186..246 CDD:290566 18/64 (28%)
LRR 5 187..208 5/22 (23%)
leucine-rich repeat 188..211 CDD:275380 6/24 (25%)
LRR 6 211..232 4/22 (18%)
leucine-rich repeat 212..235 CDD:275380 4/24 (17%)
LRR 7 235..256 9/23 (39%)
leucine-rich repeat 236..258 CDD:275380 9/24 (38%)
LRR_8 258..314 CDD:290566 13/56 (23%)
LRR 8 258..279 5/21 (24%)
leucine-rich repeat 259..282 CDD:275380 5/23 (22%)
LRR 9 282..302 4/19 (21%)
leucine-rich repeat 283..304 CDD:275380 4/20 (20%)
LRR 10 303..325 6/23 (26%)
LRR_8 305..364 CDD:290566 20/60 (33%)
leucine-rich repeat 307..348 CDD:275380 13/42 (31%)
LRR 11 329..350 6/20 (30%)
LRR 12 353..374 8/20 (40%)
leucine-rich repeat 354..375 CDD:275380 8/20 (40%)
LRR_8 375..434 CDD:290566 14/58 (24%)
LRR 13 375..396 2/20 (10%)
leucine-rich repeat 376..399 CDD:275380 3/22 (14%)
LRR 14 399..420 4/20 (20%)
leucine-rich repeat 400..421 CDD:275380 4/20 (20%)
LRR 15 423..443 8/22 (36%)
leucine-rich repeat 424..444 CDD:275380 8/22 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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