DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and AgaP_AGAP007060

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_565144.3	Gene:	AgaP_AGAP007060 / 3290298	VectorBaseID:	AGAP007060	Length:	1185	Species:	Anopheles gambiae

Alignment Length:	1040	Identity:	227/1040 - (21%)
Similarity:	369/1040 - (35%)	Gaps:	320/1040 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNYNYLTQLEVCENEMEVLDLSSLAQ---LE 92
            :|.|.:...:|.:|....|......|.:..|:...|...:..|.:.|.:::.:|..:..:   |:
Mosquito    25 DVQAYKFNLSAEYGTVEVQFEKSLVSIVPPSLFEDNGQKVDTLVMREVDVQRVDADTFTKAVALK 89

  Fly    93 TLKCSRNKLMEL----IINGTNLQTL---------VADHNY--LHNIS----TTNTHPV-PLK-- 135
            :|:..||::.:|    ..|.|||:.:         |.::.:  |.|:|    :.|..|| |.|
Mosquito    90 SLQMHRNRIPKLFNRMFRNATNLRRINFGGNRIDAVEEYTFEGLENLSVIRLSRNKIPVLPRKLF 154

  Fly   136 -----LQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRN--YRITELVSLDLAYND 193
                 |..:.:.||...|||.  |....||.::..:...|.:..|.||  ..:.||.:|.|..|.
Mosquito   155 AGLSSLTSLLLDHNRILELPE--GIFEDLTILDELYLSFNFLERLTRNSFKGLVELDNLALHNNR 217

  Fly   194 LKQLDQFPEGFSSIRSLQ---LQSNELPSL-PDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHA 254
            :..::  |:.|:|:.:||   |.||.|.|| |:.|.|.|  :|..|::|.|:|:.||:.......
Mosquito   218 ISTIE--PDTFASLATLQYLTLGSNRLTSLAPETFIAQT--KLAKLDLSVNQLAELPKDLFRYTT 278

  Fly   255 ALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGN------- 312
            ||..|.::.|.|.:...:...|.|||..|.:::|.:..|.||..||..:||:|:|..|
Mosquito   279 ALKELKISNNSLKELHSDLFANTAKLEDLVISHNEVESLDAALFRNLRKLEMLLLENNNIGHIFP 343

  Fly   313 ----MLQQL------PEEVATL--GQLRVLRCC------NNLL---------------------- 337
                .||.|      ...:.|:  |..|.||..      |||:
Mosquito   344 GTFDALQSLRALDLNQNGIMTIEGGLFRALRVLDKLYLQNNLISMVSGYSLEGAVQLTELYLNKN 408

  Fly   338 ---------LCTPQLAKLAM------------------LKVLDLSHNHLDRVNLLALVPSRNLKY 375
                     |..|.|..|||                  ||:|.|..|.|..::.....|...|:.
Mosquito   409 PLQSIDDDFLRIPSLMALAMDFCGLKTLPKGLFAKQQSLKLLFLEGNKLTDLDPDLFAPLVELEE 473

  Fly   376 LDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALP------TTKIRQVSAQRNQNKTSG 434
            ||||.||...:......:...:      |:|:|.|...:|.      .|.:::::.::|: .|..
Mosquito   474 LDLSANLLYNISNALANLTSLK------LLDLSDNRLRSLQDNAFANMTTLKKINLKQNK-LTEI 531

  Fly   435 PWTMGFAETP-----------------------------GSGDCRKL----------------SV 454
            |  ...|:.|                             |..:..||                .:
Mosquito   532 P--RALAKLPNLSTLTLETNKIKSTVVGEPLANLEDLYMGENEITKLRLNDFPAVEELYVERNQI 594

  Fly   455 YQLRAANYGG---------SDEALYGMFE------------ALEGR--GRAAQEMSHLVPDLMKQ 496
            :.|....:.|         :|..|.|..|            .|.|.  ||..:.   ....|:|.
Mosquito   595 HSLSVDTFVGNRKLKTVDLTDNRLTGPLEGIFAPLRKLVTLTLSGNPLGRVTRA---TFEGLLKL 656

  Fly   497 EQMVKDSAVRDYMKFTLLA---------------AQQQCGSVRSAALFHLTRTRAPSKVRPLKSK 546
            |    |..:|: :|.|.|.               ::.:..:|..|::      |...|:|.....
Mosquito   657 E----DLTLRN-IKLTELTGAPFASLSELEKLDLSENRLAAVDEASV------RGIGKLREFYIN 710

  Fly   547 RYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDD---EYLVVGNAQ 608
            ...:.:....|||  ::.|...:.|:...::       :||     .:|:|..   |:.|.|..
Mosquito   711 DNEIGIDGLSGLD--ILNRVQTVSLSNQSIV-------VPD-----TLLANKSWMVEFYVQGGT- 760

  Fly   609 LWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSV 673
             ::.:........|..|:.||...|:||.:.:.|            |::    |.:|
Mosquito   761 -FASLPAQFFRSTIALEKLSLSDNKQLVKLPKDF------------FQY----VPYL-------- 800

  Fly   674 RKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSG------------QSDRDLL 726
                :.:.|..:|.||.:....|.....|...|.:.||  :|.|.|            .:|.:|.
Mosquito   801 ----EELVLLNNSLSVLEPGVFDPLGLLRELDISENPL--KSLPGGLFAQTFLLESLRMADANLT 859

  Fly   727 ---AKDKDDEFVLA-------HARVLQEE--QQLEMLDETESVSESVLSEEQ---FKCWE----Y 772
               |...|..:|||       ..|.|:|.  .:|..| ||.|:..:.|...|   ||..|    .
Mosquito   860 TLPAGIFDKLYVLAKLDLANNQLRTLREGVFNRLYSL-ETLSLENNQLEALQPALFKSLEKLNIV 923

  Fly   773 MLEQNTQLLFDKEL------NTISKSFTKQRTVPNAIMA-----ATVLPERNDFTSNLMRTVTNK 826
            :|..|.....|.:|      ..|..|:.:..|...:.||     ..:..|.|..||..:.:...|
Mosquito   924 ILSHNKLAAIDPQLFAGLPVTAIDLSYNRLTTFDESAMAFAGRLLMLSMESNKLTSLKIHSTLEK 988

Fly 827 826
Mosquito 989 988

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/22 (27%)
		LRR_8	109..169	CDD:290566	21/82 (26%)
		leucine-rich repeat	111..135	CDD:275380	9/39 (23%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	6/25 (24%)
		leucine-rich repeat	184..209	CDD:275380	7/24 (29%)
		LRR_8	205..266	CDD:290566	24/64 (38%)
		leucine-rich repeat	210..230	CDD:275380	12/23 (52%)
		leucine-rich repeat	232..255	CDD:275380	7/22 (32%)
		LRR_RI	<256..410	CDD:238064	54/227 (24%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	36/153 (24%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	20/99 (20%)
		leucine-rich repeat	349..372	CDD:275380	7/22 (32%)
		PP2Cc	461..655	CDD:294085	42/234 (18%)
AgaP_AGAP007060	XP_565144.3	leucine-rich repeat	88..111	CDD:275380	6/22 (27%)
		LRR_8	110..170	CDD:290566	15/59 (25%)
		leucine-rich repeat	112..135	CDD:275380	3/22 (14%)
		leucine-rich repeat	136..159	CDD:275380	6/22 (27%)
		leucine-rich repeat	160..183	CDD:275380	8/24 (33%)
		LRR_8	166..218	CDD:290566	17/53 (32%)
		leucine-rich repeat	186..207	CDD:275380	4/20 (20%)
		LRR_8	207..266	CDD:290566	24/62 (39%)
		leucine-rich repeat	208..231	CDD:275380	7/24 (29%)
		leucine-rich repeat	232..255	CDD:275380	12/24 (50%)
		LRR_RI	236..481	CDD:238064	68/246 (28%)
		LRR_8	254..312	CDD:290566	18/59 (31%)
		leucine-rich repeat	256..279	CDD:275380	7/22 (32%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		LRR_8	303..362	CDD:290566	17/58 (29%)
		leucine-rich repeat	304..327	CDD:275380	8/22 (36%)
		leucine-rich repeat	328..351	CDD:275380	6/22 (27%)
		LRR_8	351..410	CDD:290566	9/58 (16%)
		leucine-rich repeat	352..375	CDD:275380	5/22 (23%)
		leucine-rich repeat	376..399	CDD:275380	3/22 (14%)
		LRR_8	421..481	CDD:290566	18/59 (31%)
		leucine-rich repeat	423..446	CDD:275380	4/22 (18%)
		leucine-rich repeat	447..468	CDD:275380	6/20 (30%)
		LRR_RI	448..690	CDD:238064	45/258 (17%)
		leucine-rich repeat	471..493	CDD:275380	7/21 (33%)
		LRR_8	492..551	CDD:290566	11/67 (16%)
		leucine-rich repeat	494..517	CDD:275380	5/28 (18%)
		leucine-rich repeat	518..540	CDD:275380	4/24 (17%)
		leucine-rich repeat	541..562	CDD:275380	0/20 (0%)
		leucine-rich repeat	563..583	CDD:275380	3/19 (16%)
		LRR_8	582..642	CDD:290566	8/59 (14%)
		leucine-rich repeat	584..604	CDD:275380	1/19 (5%)
		leucine-rich repeat	608..631	CDD:275380	4/22 (18%)
		LRR_8	630..690	CDD:290566	12/67 (18%)
		leucine-rich repeat	632..655	CDD:275380	5/25 (20%)
		leucine-rich repeat	656..679	CDD:275380	6/27 (22%)
		leucine-rich repeat	680..703	CDD:275380	3/28 (11%)
		leucine-rich repeat	704..750	CDD:275380	10/59 (17%)
		LRR_RI	<764..978	CDD:238064	54/244 (22%)
		LRR_8	775..834	CDD:290566	17/86 (20%)
		leucine-rich repeat	775..799	CDD:275380	9/39 (23%)
		leucine-rich repeat	800..823	CDD:275380	6/34 (18%)
		leucine-rich repeat	824..847	CDD:275380	7/24 (29%)
		LRR_8	848..906	CDD:290566	15/58 (26%)
		leucine-rich repeat	848..871	CDD:275380	4/22 (18%)
		leucine-rich repeat	872..895	CDD:275380	6/22 (27%)
		LRR_RI	875..1133	CDD:238064	27/115 (23%)
		LRR_8	895..953	CDD:290566	15/58 (26%)
		leucine-rich repeat	896..919	CDD:275380	8/23 (35%)
		leucine-rich repeat	920..941	CDD:275380	4/20 (20%)
		leucine-rich repeat	943..966	CDD:275380	5/22 (23%)
		leucine-rich repeat	1032..1080	CDD:275380
		leucine-rich repeat	1057..1078	CDD:275378
		leucine-rich repeat	1081..1104	CDD:275380
		leucine-rich repeat	1105..1123	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910