DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Lrfn2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001034788.1	Gene:	Lrfn2 / 316205	RGDID:	1311831	Length:	788	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	157/788 - (19%)
Similarity:	257/788 - (32%)	Gaps:	261/788 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 QLGGSILI-------GNYNYLTQLEVCENEMEVLDLSSLAQLETLK---CSRNKLMEL---IING 108
            :|||:.:|       .|...|..|.:..|.:..:...|...||:|:   ...|:|..|   .:.|
  Rat    58 RLGGNFIIHIGRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRG 122

  Fly   109 -TNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNW--VGACASLTAINASHNRLN 170
             .|||.|:.::|.|..|:........|.|:.:|:|:||...|| |  |....:|..::..||.|:
  Rat   123 LVNLQHLIVNNNQLGGIADDAFEDFLLTLEDLDLSYNNLHGLP-WDSVRRMVNLHQLSLDHNLLD 186

  Fly   171 NVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSL-PDNFFAVTHARLET 234
            ::|              :..:.||::|.:          |.|.||.|..| ||..||.:.|.|
  Rat   187 HIA--------------EGTFADLQKLAR----------LDLTSNRLQKLPPDPIFARSQASL-- 225

  Fly   235 LNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVR 299
                   |:..|      .|..::.|..||        |||                   ..|..
  Rat   226 -------LTATP------FAPPLSFSFGGN--------PLH-------------------CNCEL 250

  Fly   300 NW-------PELEIL----VLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLD 353
            .|       .:||..    .|.|.....:.||.               .:|.|.|.
  Rat   251 LWLRRLERDDDLETCGSPGGLKGRYFWHIREEE---------------FVCEPPLI--------- 291

  Fly   354 LSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQR-HWSLVD---VSGNNRAA 414
            ..|.|               |.|.|.|    |....:.|.....|.. ||...|   |..::|.|
  Rat   292 TQHTH---------------KLLVLEG----QAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTA 337

  Fly   415 LPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCR-KLSVYQL---------------RAANYG 463
            :.......:....:|:  |||:|...|...|..... ::|:.||               |.::..
  Rat   338 VYDNGTLDILITTSQD--SGPFTCIAANAAGEATATVEVSIVQLPHLSNSTSRMAPPKSRLSDIT 400

  Fly   464 GSDEALYGMFEALEGRG-------RAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCG 521
            ||.:...|      |.|       ::..|.:.||.|:.....:||.|..:...:..:...|..|.
  Rat   401 GSSKTSRG------GGGSGAGEPPKSTPERAVLVSDVTTTSALVKWSVSKSAPRVKMYQLQYNCS 459

  Fly   522 SVRSAALFHLTRTRAPSKVRPLKSKRYVL-RMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSM 585
            .  ...|.:        ::.|..:|.:|: .:.|..|.|..::                    :|
  Rat   460 D--DEVLIY--------RMIPASNKAFVVNNLVSGTGYDLCVL--------------------AM 494

  Fly   586 PDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSV 650
            .|.....|..:|     :||.||.::..|..    :.:...:.:|....::.|.....|...:.:
  Rat   495 WDDTATTLTATN-----IVGCAQFFTKADYP----QCQSMHSQILGGTMILVIGGIIVATLLVFI 550

  Fly   651 IVVRFRHLGTDVD--------HLIRELKQSVRKKPQPV------SLPLSSGSVCKRT-------- 693
            :::..|:...:.|        .:.....|:...:|.|:      .||.:...|..|.
  Rat   551 VILMVRYKVCNHDAPGKMAAATVSNVYSQTNGAQPPPLGGMPVGQLPQAPPKVVVRNELMDFSTS 615

  Fly   694 ---CCDRSNACRHRAIEQ----------EPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARV-LQE 744
               .||.|::....:.|.          .|.|.|..||            .|..:.|.|.: |:.
  Rat   616 LARACDSSSSSSLGSGEAAGLSRGPWRLPPPAPRPKPS------------LDRLMGAFASLDLKS 668

  Fly   745 EQQLEMLD 752
            :::.|:||
  Rat   669 QRKEELLD 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/25 (28%)
		LRR_8	109..169	CDD:290566	20/61 (33%)
		leucine-rich repeat	111..135	CDD:275380	6/23 (26%)
		leucine-rich repeat	136..158	CDD:275380	9/23 (39%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	3/24 (13%)
		LRR_8	205..266	CDD:290566	18/61 (30%)
		leucine-rich repeat	210..230	CDD:275380	10/20 (50%)
		leucine-rich repeat	232..255	CDD:275380	3/22 (14%)
		LRR_RI	<256..410	CDD:238064	30/168 (18%)
		leucine-rich repeat	256..276	CDD:275380	5/19 (26%)
		LRR_8	279..359	CDD:290566	12/90 (13%)
		leucine-rich repeat	280..303	CDD:275380	2/29 (7%)
		leucine-rich repeat	304..348	CDD:275380	9/47 (19%)
		leucine-rich repeat	349..372	CDD:275380	2/22 (9%)
		PP2Cc	461..655	CDD:294085	33/201 (16%)
Lrfn2	NP_001034788.1	LRR_RI	27..>209	CDD:238064	45/175 (26%)
		LRR 1	53..74		4/15 (27%)
		leucine-rich repeat	54..77	CDD:275380	5/18 (28%)
		LRR_8	76..136	CDD:290566	16/59 (27%)
		LRR 2	77..98		4/20 (20%)
		leucine-rich repeat	78..101	CDD:275380	5/22 (23%)
		LRR 3	101..122		4/20 (20%)
		leucine-rich repeat	102..125	CDD:275380	5/22 (23%)
		LRR_8	125..185	CDD:290566	20/60 (33%)
		LRR 4	125..146		7/20 (35%)
		leucine-rich repeat	126..150	CDD:275380	6/23 (26%)
		LRR 5	150..171		9/21 (43%)
		leucine-rich repeat	151..174	CDD:275380	9/23 (39%)
		LRR_8	174..>215	CDD:290566	14/64 (22%)
		LRR 6	174..195		5/34 (15%)
		leucine-rich repeat	175..198	CDD:275380	7/36 (19%)
		LRR 7	198..219		9/30 (30%)
		LRRCT	242..286	CDD:214507	12/85 (14%)
		IG_like	298..376	CDD:214653	19/83 (23%)
		Ig	303..376	CDD:299845	17/78 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..423		6/45 (13%)
		fn3	428..493	CDD:278470	14/94 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	620..655		9/46 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..707		3/9 (33%)
		PDZ-binding	785..788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000