DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Lrfn5

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001101494.1	Gene:	Lrfn5 / 314164	RGDID:	1309357	Length:	719	Species:	Rattus norvegicus

Alignment Length:	846	Identity:	166/846 - (19%)
Similarity:	286/846 - (33%)	Gaps:	256/846 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMEL--IINGTNLQTLVADHNYLHNIS 125
            |||   ...:.::|........||  ..|.|| |::..|:.:  .|:...::..:|| |::.||.
  Rat    10 LIG---IAVRAQICPKRCVCQILS--PNLATL-CAKKGLLFVPPNIDRRTVELRLAD-NFVTNIK 67

  Fly   126 TTN----THPVPLKLQRIDISH---NNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITE 183
            ..:    |..|.|.|.|..||.   :.|::|.|       |.|::.:.|||..:.
  Rat    68 RKDFANMTSLVDLTLSRNTISFITPHAFADLRN-------LRALHLNSNRLTKIT---------- 115

  Fly   184 LVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLP----DNFFAVTHARLETLNVSCNKLST 244
                    ||:.      .|.|::..|.|.:|:|..:.    |:.||     ||.|::|.|.|.|
  Rat   116 --------NDMF------SGLSNLHHLILNNNQLTLISSTAFDDVFA-----LEELDLSYNNLET 161

  Fly   245 LPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVL 309
            :|                        ::.:.....|..|.|.:|.|..:|.....:..::..|.:
  Rat   162 IP------------------------WDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLHKMTRLDV 202

  Fly   310 SGNMLQQLPEE--------VATLGQLR----VLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRV 362
            :.|.||:||.:        :||.|.:.    .|....|.|.|..:|..|          ..|.|.
  Rat   203 TSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGNPLHCNCELLWL----------RRLSRE 257

  Fly   363 NLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQ-SQRHWSLVDVSGNNRAAL-------PTTK 419
            :.|....|..|    |:|.....:.|::| :|:.. ..||...:.|....||.|       |...
  Rat   258 DDLETCASPAL----LTGRYFWSIPEEEF-LCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPA 317

  Fly   420 IRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQ 484
            |..:|.   :.|.....|.......|:.|....:|....|.....|:.|           |.|.|
  Rat   318 IHWISP---EGKLISNATRSLVYDNGTLDILITTVKDTGAFTCIASNPA-----------GEATQ 368

  Fly   485 EMS-HLV--PDLMKQEQMV--KDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLK 544
            .|. |::  |.|:.....:  .|....|      ::...:.||..|:       :...:|:.  :
  Rat   369 TMDLHIIKLPHLLNSTNNIHEPDPGSSD------ISTSTKSGSNASS-------SNGDTKMS--Q 418

  Fly   545 SKRYVLRMASTGGLDAYLIRRT--------SQLRLTKPDVIQKDQIHSMPDPHVLELILSN---- 597
            .|..|...:|:..|..:..:|.        .|...|..|.:    ::.|..|.....:::|
  Rat   419 DKIVVAEASSSTALLKFNFQRNIPGIRMFQIQYNGTYDDTL----VYRMIPPTSKTFLVNNLASG 479

  Fly   598 -----------DDEYL------VVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAA 645
                       ||...      |||..|..:..|..|.    ...::..|....::.|.....|:
  Rat   480 TMYDLCVLAIYDDGITSLTATRVVGCIQFTTEQDYVRC----HFMQSQFLGGTMIIIIGGIIVAS 540

  Fly   646 ESLSVIV--VRFRHLGTDVDHLIRELK------QSVRKKPQPVSLPLS----------SGSVCK- 691
            ..:.:|:  :|::....:..|.:.::.      ...:.:...|:||.|          :...||
  Rat   541 VLVFIIILMIRYKVCNNNGQHKVTKVSNVYSQTNGAQMQGCSVTLPQSMSKQAMGHEENAQCCKV 605

  Fly   692 ---------RTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVLQEEQQ 747
                     .||..:.::....|:  .|....|:|..|                      :::::
  Rat   606 ASDSAIQSSETCSSQDSSTTTSAL--PPTWTSSAPVSQ----------------------KQKRK 646

  Fly   748 LEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKEL-------NTISKSFTKQR--TVPNAI 803
            .......|..||:|.:.|         .|||.......|       :::::..|.||  |.|||:
  Rat   647 TGTKPSAEPQSEAVTNVE---------SQNTNRNNSTALQLASCPPDSVTEGPTSQRAHTKPNAL 702

  Fly   804 M 804
            :
  Rat   703 L 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/20 (30%)
		LRR_8	109..169	CDD:290566	18/66 (27%)
		leucine-rich repeat	111..135	CDD:275380	7/27 (26%)
		leucine-rich repeat	136..158	CDD:275380	7/24 (29%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	4/24 (17%)
		LRR_8	205..266	CDD:290566	16/64 (25%)
		leucine-rich repeat	210..230	CDD:275380	7/23 (30%)
		leucine-rich repeat	232..255	CDD:275380	8/22 (36%)
		LRR_RI	<256..410	CDD:238064	34/166 (20%)
		leucine-rich repeat	256..276	CDD:275380	0/19 (0%)
		LRR_8	279..359	CDD:290566	21/91 (23%)
		leucine-rich repeat	280..303	CDD:275380	6/22 (27%)
		leucine-rich repeat	304..348	CDD:275380	15/55 (27%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		PP2Cc	461..655	CDD:294085	38/229 (17%)
Lrfn5	NP_001101494.1	LRR 1	52..73		5/21 (24%)
		leucine-rich repeat	53..76	CDD:275380	5/23 (22%)
		PPP1R42	56..211	CDD:411060	49/215 (23%)
		LRR 2	76..97		7/20 (35%)
		leucine-rich repeat	77..100	CDD:275380	8/22 (36%)
		LRR 3	100..121		8/51 (16%)
		leucine-rich repeat	101..124	CDD:275380	8/46 (17%)
		LRR 4	124..145		4/20 (20%)
		leucine-rich repeat	125..148	CDD:275380	5/22 (23%)
		LRR 5	148..169		9/49 (18%)
		leucine-rich repeat	149..172	CDD:275380	8/46 (17%)
		LRR 6	172..193		6/20 (30%)
		leucine-rich repeat	173..196	CDD:275380	6/22 (27%)
		LRR 7	196..217		6/20 (30%)
		leucine-rich repeat	197..215	CDD:275380	6/17 (35%)
		TPKR_C2	240..>272	CDD:417692	11/45 (24%)
		IgI_SALM5_like	287..374	CDD:409421	21/100 (21%)
		Ig strand B	304..308	CDD:409421	2/3 (67%)
		Ig strand C	317..321	CDD:409421	1/3 (33%)
		Ig strand E	340..344	CDD:409421	1/3 (33%)
		Ig strand F	354..359	CDD:409421	1/4 (25%)
		Ig strand G	367..370	CDD:409421	1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..416		5/45 (11%)
		FN3	421..494	CDD:419708	12/76 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..719		23/123 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000