DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Lrrc40

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_006233600.1	Gene:	Lrrc40 / 310946	RGDID:	1562017	Length:	602	Species:	Rattus norvegicus

Alignment Length:	353	Identity:	100/353 - (28%)
Similarity:	170/353 - (48%)	Gaps:	47/353 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 GQTSPQKLSLKGSQLGGSILIGNYN--------YLTQLEVCENEMEVLDLSSLAQLETLKCSRNK 100
            |.|.||.| ||.::..|.:.:...|        :...:::.|...:.|..||..:.    ..:..
  Rat    24 GPTVPQGL-LKAARSSGQLNLAGRNLGEVPQCVWRINVDIPEEANQNLSFSSTERW----WEQTD 83

  Fly   101 LMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINAS 165
            |.:|||:...||:|..|...|..::.            :||..|..:.||:.:....:|..:|.|
  Rat    84 LTKLIISSNKLQSLSDDLRLLPALTV------------LDIHDNQLTSLPSAIRELDNLQKLNVS 136

  Fly   166 HNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGF---SSIRSLQLQSNELPSLPDNFFAV 227
            ||:|..:...:.:  :..|.:|.|.:|:|..:   ||||   ||:..|.|.||.|.::|.:|..:
  Rat   137 HNKLKMLPEEITS--LKNLKALHLQHNELTCI---PEGFEHLSSLEDLDLSSNRLATVPADFALL 196

  Fly   228 THARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGV 292
            ::  |..||:|.|:|..||. |.:....|.:|....| |.:::...:.:...|.:|:|..|::.|
  Rat   197 SN--LLRLNLSSNQLKNLPA-EISRMKRLKHLDCDAN-LLETVPPDVGSMESLELLYLRRNKLRV 257

  Fly   293 LP--AACVRNWPELEILVLSGNMLQQL-PEEVATLGQLRVLRCCNNLLLCTP-QLAKLAMLKVLD 353
            ||  .:|    .:|:.|.|:.|.:::| .|.:..|..:.||...:|.|...| ::|.|..|:.||
  Rat   258 LPEFPSC----RQLKELYLAENQIEKLGAEHLQHLQAILVLDLRSNKLRSVPEEMALLQSLERLD 318

  Fly   354 LSHNHLDRVNLLALVPSRNLKYLDLSGN 381
            ||:|  |..:|...:.:.:||:|.|.||
  Rat   319 LSNN--DISSLPCSLGNLHLKFLALEGN 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/18 (22%)
		LRR_8	109..169	CDD:290566	15/59 (25%)
		leucine-rich repeat	111..135	CDD:275380	5/23 (22%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	11/27 (41%)
		LRR_8	205..266	CDD:290566	21/60 (35%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	9/22 (41%)
		LRR_RI	<256..410	CDD:238064	40/130 (31%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	28/83 (34%)
		leucine-rich repeat	280..303	CDD:275380	8/24 (33%)
		leucine-rich repeat	304..348	CDD:275380	14/45 (31%)
		leucine-rich repeat	349..372	CDD:275380	8/22 (36%)
		PP2Cc	461..655	CDD:294085
Lrrc40	XP_006233600.1	leucine-rich repeat	84..106	CDD:275380	9/21 (43%)
		PLN00113	89..>577	CDD:215061	84/283 (30%)
		leucine-rich repeat	107..129	CDD:275380	5/33 (15%)
		leucine-rich repeat	130..152	CDD:275380	6/23 (26%)
		leucine-rich repeat	153..175	CDD:275380	9/24 (38%)
		leucine-rich repeat	176..221	CDD:275380	16/47 (34%)
		leucine-rich repeat	222..244	CDD:275380	4/22 (18%)
		leucine-rich repeat	245..266	CDD:275380	8/24 (33%)
		leucine-rich repeat	267..290	CDD:275380	7/22 (32%)
		leucine-rich repeat	291..313	CDD:275380	7/21 (33%)
		leucine-rich repeat	427..473	CDD:275380
		leucine-rich repeat	474..496	CDD:275380
		leucine-rich repeat	497..519	CDD:275380
		leucine-rich repeat	520..543	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45752
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100