DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Lrrc4b

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001258010.1 Gene:Lrrc4b / 308571 RGDID:1307121 Length:709 Species:Rattus norvegicus


Alignment Length:271 Identity:72/271 - (26%)
Similarity:122/271 - (45%) Gaps:55/271 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   138 RIDISHNNFSELPNWVGACASLTAINASHNRL--NNVAVL----LRNYRITELVSLDLAYNDLKQ 196
            |:..:....:|:|      ||: .:|..:..|  |::.|:    .::.|..|:  |.|:.|.:::
  Rat    71 RVICTRRELAEVP------ASI-PVNTRYLNLQENSIQVIRTDTFKHLRHLEI--LQLSKNLVRK 126

  Fly   197 LD--QFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNL 259
            ::  .| .|..|:.:|:|..|.|.::|...|... ::|..|.:..|.:.::|.|..|...:|..|
  Rat   127 IEVGAF-NGLPSLNTLELFDNRLTTVPTQAFEYL-SKLRELWLRNNPIESIPSYAFNRVPSLRRL 189

  Fly   260 SLAG----NHLNDSIFEPLHNAAKLRVLHLAYNRIGVLP--AACVRNWPELEILVLSGNMLQQLP 318
            .|..    .:::::.||.|.|   ||.|:|....:..:|  .|.||    ||.|.||||.|    
  Rat   190 DLGELKRLEYISEAAFEGLVN---LRYLNLGMCNLKDIPNLTALVR----LEELELSGNRL---- 243

  Fly   319 EEVATLGQLRVLRCCNNLLLCTPQLA--------KLAMLKVLDLSHNHLDRVNLLAL-----VPS 370
             ::...|..:.|.....|.|...|:|        .|..|:.|:||||     ||::|     .|.
  Rat   244 -DLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHN-----NLMSLPHDLFTPL 302

  Fly   371 RNLKYLDLSGN 381
            ..|:.:.|:.|
  Rat   303 HRLERVHLNHN 313

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566 6/30 (20%)
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380 3/19 (16%)
leucine-rich repeat 159..183 CDD:275380 5/29 (17%)
leucine-rich repeat 184..209 CDD:275380 6/26 (23%)
LRR_8 205..266 CDD:290566 16/64 (25%)
leucine-rich repeat 210..230 CDD:275380 6/19 (32%)
leucine-rich repeat 232..255 CDD:275380 6/22 (27%)
LRR_RI <256..410 CDD:238064 43/145 (30%)
leucine-rich repeat 256..276 CDD:275380 6/23 (26%)
LRR_8 279..359 CDD:290566 29/89 (33%)
leucine-rich repeat 280..303 CDD:275380 8/24 (33%)
leucine-rich repeat 304..348 CDD:275380 15/51 (29%)
leucine-rich repeat 349..372 CDD:275380 10/27 (37%)
PP2Cc 461..655 CDD:294085
Lrrc4bNP_001258010.1 LRRNT 59..92 CDD:214470 6/27 (22%)
LRR <89..299 CDD:227223 63/230 (27%)
LRR 1 89..110 4/20 (20%)
leucine-rich repeat 90..113 CDD:275380 3/22 (14%)
LRR 2 113..134 5/23 (22%)
leucine-rich repeat 114..137 CDD:275380 6/25 (24%)
LRR 3 137..158 7/20 (35%)
leucine-rich repeat 138..161 CDD:275380 6/23 (26%)
LRR 4 161..182 5/20 (25%)
leucine-rich repeat 162..185 CDD:275380 6/22 (27%)
LRR 5 185..207 4/21 (19%)
leucine-rich repeat 186..210 CDD:275380 6/23 (26%)
LRR 6 210..231 7/23 (30%)
leucine-rich repeat 211..232 CDD:275380 6/20 (30%)
LRR 7 232..253 10/29 (34%)
leucine-rich repeat 233..256 CDD:275380 10/27 (37%)
LRR 8 256..277 4/20 (20%)
leucine-rich repeat 257..280 CDD:275380 5/22 (23%)
LRR 9 280..301 9/25 (36%)
leucine-rich repeat 281..302 CDD:275380 9/25 (36%)
LRRCT 313..363 CDD:214507 1/1 (100%)
I-set 366..455 CDD:400151
Ig strand A 366..369 CDD:409353
Ig strand A' 373..376 CDD:409353
Ig strand B 382..389 CDD:409353
Ig strand C 395..400 CDD:409353
Ig strand C' 403..405 CDD:409353
Ig strand D 414..418 CDD:409353
Ig strand E 421..425 CDD:409353
Ig strand F 435..442 CDD:409353
Ig strand G 445..455 CDD:409353
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..552
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X32
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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