DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Lrrc18

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_017455569.1	Gene:	Lrrc18 / 306278	RGDID:	1311738	Length:	262	Species:	Rattus norvegicus

Alignment Length:	279	Identity:	69/279 - (24%)
Similarity:	115/279 - (41%)	Gaps:	63/279 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 QRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFP 201
            :|:|:|....:..|..:                         .|:.|:..|||:.|.::::....
  Rat    30 KRLDLSKMGITTFPKCI-------------------------LRLNEIDELDLSRNMIRKIPDSI 69

  Fly   202 EGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLST--LP-RYEQNNHAALVNLSLAG 263
            ..|.::|.|.|.||.:..||::...:|  .|..||||.|:|:|  || ...|..:...|||.|
  Rat    70 SKFQNLRWLDLHSNYIDKLPESIGQMT--SLLFLNVSNNRLTTNGLPVELNQLKNIRTVNLGL-- 130

  Fly   264 NHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEE----VATL 324
            ||| ||:...|....:|..:.|..|.:..:||. :...|:|:.|.:..|...: |:|    |.::
  Rat   131 NHL-DSVPTTLGALKELHEVGLHDNLLTSIPAG-ISKLPKLKKLNVKRNPFPK-PDESDMFVDSI 192

  Fly   325 GQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVN-LLALVPSRNLKYLD---LSGNLQLQ 385
            .:|..|.......||:..|.|....:         |::| :.::.||...|.:.   :|.|...:
  Rat   193 KRLENLYLVEEKDLCSSCLQKCQQAR---------DKLNKIRSMAPSAPRKAIFSNLVSPNSTAK 248

  Fly   386 VDEQQFKVCQSQSQRHWSL 404
                       :||..|.|
  Rat   249 -----------ESQEEWRL 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566	4/31 (13%)
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380	4/20 (20%)
		leucine-rich repeat	159..183	CDD:275380	1/23 (4%)
		leucine-rich repeat	184..209	CDD:275380	5/24 (21%)
		LRR_8	205..266	CDD:290566	24/63 (38%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	11/25 (44%)
		LRR_RI	<256..410	CDD:238064	39/157 (25%)
		leucine-rich repeat	256..276	CDD:275380	10/19 (53%)
		LRR_8	279..359	CDD:290566	18/83 (22%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	12/47 (26%)
		leucine-rich repeat	349..372	CDD:275380	4/23 (17%)
		PP2Cc	461..655	CDD:294085
Lrrc18	XP_017455569.1	leucine-rich repeat	30..51	CDD:275380	5/45 (11%)
		leucine-rich repeat	52..74	CDD:275380	5/21 (24%)
		PLN00113	55..>200	CDD:215061	48/151 (32%)
		leucine-rich repeat	75..97	CDD:275380	8/23 (35%)
		leucine-rich repeat	98..122	CDD:275380	11/23 (48%)
		leucine-rich repeat	123..145	CDD:275380	10/24 (42%)
		leucine-rich repeat	146..168	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45752
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100