DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and GUCY2F

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001513.2	Gene:	GUCY2F / 2986	HGNCID:	4691	Length:	1108	Species:	Homo sapiens

Alignment Length:	753	Identity:	127/753 - (16%)
Similarity:	239/753 - (31%)	Gaps:	278/753 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 VTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIG 291
            |.|:|    |:..:..:.|.|.:.|           ||.:::.:.  |....|...||..|. :.
Human   379 VQHSR----NMQFHGFNQLMRTDSN-----------GNGISEYVI--LDTNLKEWELHSTYT-VD 425

  Fly   292 VLPAACVRNWPELEILVLSGNMLQ----QLPEEVATLGQLRVLRC-------CNN-------LLL 338
            :          |:|:|...|..:.    :.|...|        :|       |:.       :::
Human   426 M----------EMELLRFGGTPIHFPGGRPPRADA--------KCWFAEGKICHGGIDPAFAMMV 472

  Fly   339 CTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWS 403
            |...|  :|:|.:...::....|:|.:.|:...|        .:.|.:::..|......|:|
Human   473 CLTLL--IALLSINGFAYFIRRRINKIQLIKGPN--------RILLTLEDVTFINPHFGSKR--- 524

  Fly   404 LVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQ-----LRAANYG 463
                  .:||::......:|.:.|:...:....::    ||.:.:...:::|:     |:..:.|
Human   525 ------GSRASVSFQITSEVQSGRSPRLSFSSGSL----TPATYENSNIAIYEGDWVWLKKFSLG 579

  Fly   464 GSDEALYGMFEALEGRGRAAQEMSHLVPDL----------------------------------- 493
            .     :|..::::.|   |.::..::.||
Human   580 D-----FGDLKSIKSR---ASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILT 636

  Fly   494 ---MKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSK------RYV 549
               :|.:.|.|.|.:.|.:|.......::....|                  |||:      |:|
Human   637 NQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGR------------------LKSRNCVVDGRFV 683

  Fly   550 LRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMD 614
            |::...|..|                              :||::..:::|..:  ...||:..:
Human   684 LKVTDYGFND------------------------------ILEMLRLSEEESSM--EELLWTAPE 716

  Fly   615 IDRAAREIRKEENSLLAAKRLVDIA---QSFAAAESLSVIVVR---FRHLGTDVDHLIRELKQSV 673
            :.||.|           ..||...|   .|||..  :..::||   |..:......:|..|
Human   717 LLRAPR-----------GSRLGSFAGDVYSFAII--MQEVMVRGTPFCMMDLPAQEIINRL---- 764

  Fly   674 RKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAG----------------------RSS 716
             |||.||..|:.........|......|...|.||.|...                      |..
Human   765 -KKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRML 828

  Fly   717 PSGQSDRDLLAKDKDDEFVLAHARVLQEEQQLEML-------DETESVSESVLSEEQ-------- 766
            ....|:.:.|.:::.:|..:       |:|:.|.|       ...||:.:....|.:
Human   829 EQYSSNLEDLIRERTEELEI-------EKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLY 886

  Fly   767 ------FKCWEYMLE--------QNTQLLFDKELNTISKSFTKQRTVPNAIMAATVLPERN---- 813
                  |.....|.|        .:...|||..:.  |....|..|:.:|.|.|:.||:||
Human   887 FSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIG--SHDVYKVETIGDAYMVASGLPKRNGSRH 949

  Fly   814 -----DFTSNLMRTVTNKFISTSTPQLPQPITTSVPLG 846
                 :.:.:::.:| ..|.....|::|..|...:..|
Human   950 AAEIANMSLDILSSV-GTFKMRHMPEVPVRIRIGLHSG 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566	9/38 (24%)
		leucine-rich repeat	210..230	CDD:275380	1/2 (50%)
		leucine-rich repeat	232..255	CDD:275380	4/22 (18%)
		LRR_RI	<256..410	CDD:238064	27/171 (16%)
		leucine-rich repeat	256..276	CDD:275380	3/19 (16%)
		LRR_8	279..359	CDD:290566	16/97 (16%)
		leucine-rich repeat	280..303	CDD:275380	3/22 (14%)
		leucine-rich repeat	304..348	CDD:275380	9/61 (15%)
		leucine-rich repeat	349..372	CDD:275380	4/22 (18%)
		PP2Cc	461..655	CDD:294085	37/243 (15%)
GUCY2F	NP_001513.2	PBP1_sensory_GC_DEF_like	54..435	CDD:107366	17/83 (20%)
		ANF_receptor	75..412	CDD:279440	10/49 (20%)
		PKc_like	545..815	CDD:304357	56/349 (16%)
		HNOBA	<824..869	CDD:285003	9/51 (18%)
		CYCc	848..1040	CDD:214485	29/149 (19%)
		Guanylate_cyc	875..1062	CDD:278633	23/115 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900