DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Phlpp and GUCY2C

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_004954.2 Gene:GUCY2C / 2984 HGNCID:4688 Length:1073 Species:Homo sapiens


Alignment Length:945 Identity:164/945 - (17%)
Similarity:289/945 - (30%) Gaps:352/945 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 LKGSQLGGSILIG-NYNYLTQLEVCENEMEV---------LDLSSLAQLETLKCSRNKLMELIIN 107
            :..:|..|.:||| :..|.|.....:.|:..         |.......|..|.....|||..::|
Human   109 ISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVN 173

  Fly   108 --GTN---LQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACASLTA------ 161
              .||   .:|.....:|::. :.|.|......|..::.|.:.||   :.:|....|..      
Human   174 FWKTNDLPFKTYSWSTSYVYK-NGTETEDCFWYLNALEASVSYFS---HELGFKVVLRQDKEFQD 234

  Fly   162 INASHNRLNNVAVL---------LRNYR-ITE---LVSLDLAYNDLKQLDQFPEGFSSIRSLQLQ 213
            |...|||.:||.::         |:..| :.|   ::.:|| :|     ||:.|           
Human   235 ILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDL-FN-----DQYFE----------- 282

  Fly   214 SNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAA 278
                    ||.                   |.|.|.:|   .||.....||.|.:|.|....:..
Human   283 --------DNV-------------------TAPDYMKN---VLVLTLSPGNSLLNSSFSRNLSPT 317

  Fly   279 KLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNL------- 336
            | |...|||                |..::|.|:||:...|....:...:......||       
Human   318 K-RDFALAY----------------LNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDG 365

  Fly   337 ---------------LLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPS---RNLKY-LDLSGN- 381
                           ||.|....|  ..|||.....|:::...:.:.|:   :|.|. .|::|. 
Human   366 PVTLDDWGDVDSTMVLLYTSVDTK--KYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRG 428

  Fly   382 -----------------------LQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQV 423
                                   |.|:...:.:::    .|:.||  .:...|...|.|.:...|
Human   429 PQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYEL----RQKKWS--HIPPENIFPLETNETNHV 487

  Fly   424 SAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGS----------------------- 465
            |.:.:.:|                  |:.::.:||...|...                       
Human   488 SLKIDDDK------------------RRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELN 534

  Fly   466 -------------------DEALYGMFEALEGRGRAAQEMSHLV--PDLMKQEQMVKDSAVRDYM 509
                               |..::|:.|..| ||...:.::..:  ||....:...|.|.:.|..
Human   535 KLLQIDYYNLTKFYGTVKLDTMIFGVIEYCE-RGSLREVLNDTISYPDGTFMDWEFKISVLYDIA 598

  Fly   510 KFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRP---LKSKRYVLRMASTGGLDAYLIRR----TS 567
            |              ..:..|.::|....:::.   :...|.|:::... |.::.|..:    |:
Human   599 K--------------GMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDF-GCNSILPPKKDLWTA 648

  Fly   568 QLRLTKPDVIQKDQIHSM----------------------------------PDPHVLELILSND 598
            ...|.:.::.||..::|.                                  ..|...:|.|...
Human   649 PEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETA 713

  Fly   599 DE-----YLVVGNAQLWSVMDIDRAAR-EIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRH 657
            :|     ||:|.|.  |   :.|...| :.:|.|.:|   .::..:.........:..::.|.:.
Human   714 EEKELEVYLLVKNC--W---EEDPEKRPDFKKIETTL---AKIFGLFHDQKNESYMDTLIRRLQL 770

  Fly   658 LGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSD 722
            ...:::||:.|..|..:               .:|...||.|                       
Human   771 YSRNLEHLVEERTQLYK---------------AERDRADRLN----------------------- 797

  Fly   723 RDLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQNTQLLFDKELN 787
                       |:|....|::..::...: |.|...|..:.......:..:.:.:|.:.....||
Human   798 -----------FMLLPRLVVKSLKEKGFV-EPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLN 850

  Fly   788 TISKSFT---------KQRTVPNAIMAATVLPERN 813
            .|.|||.         |..|:.:|.|.|:.||:||
Human   851 DIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRN 885

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 6/20 (30%)
LRR_8 109..169 CDD:290566 15/68 (22%)
leucine-rich repeat 111..135 CDD:275380 4/23 (17%)
leucine-rich repeat 136..158 CDD:275380 5/21 (24%)
leucine-rich repeat 159..183 CDD:275380 9/39 (23%)
leucine-rich repeat 184..209 CDD:275380 6/24 (25%)
LRR_8 205..266 CDD:290566 10/60 (17%)
leucine-rich repeat 210..230 CDD:275380 2/19 (11%)
leucine-rich repeat 232..255 CDD:275380 4/22 (18%)
LRR_RI <256..410 CDD:238064 38/203 (19%)
leucine-rich repeat 256..276 CDD:275380 7/19 (37%)
LRR_8 279..359 CDD:290566 20/101 (20%)
leucine-rich repeat 280..303 CDD:275380 4/22 (18%)
leucine-rich repeat 304..348 CDD:275380 12/65 (18%)
leucine-rich repeat 349..372 CDD:275380 5/25 (20%)
PP2Cc 461..655 CDD:294085 38/284 (13%)
GUCY2CNP_004954.2 PBP1_GC_C_enterotoxin_receptor 35..415 CDD:107364 77/375 (21%)
PK_GC-C 480..750 CDD:270946 45/311 (14%)
Pkinase_Tyr 502..745 CDD:285015 39/263 (15%)
CYCc 788..979 CDD:214485 26/133 (20%)
Guanylate_cyc 815..1002 CDD:278633 19/72 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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