DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and GUCY1B1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_011530203.1	Gene:	GUCY1B1 / 2983	HGNCID:	4687	Length:	662	Species:	Homo sapiens

Alignment Length:	321	Identity:	67/321 - (20%)
Similarity:	103/321 - (32%)	Gaps:	116/321 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 LPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAAC--VRNWPELEIL 307
            ||:.:..|.:.|...||...|::.|....|.:...:.||......:.|....|  .....|:..|
Human   240 LPQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTEISCL 304

  Fly   308 VLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVP--- 369
            .|.|.|: .|||..:.            |.||:|.:..|.     ||:...|    .|:.:|
Human   305 RLKGQMI-YLPEADSI------------LFLCSPSVMNLD-----DLTRRGL----YLSDIPLHD 347

  Fly   370 -SRNLKYLD---------------LSGNLQLQV----DE------------QQFKV------CQS 396
             :|:|..|.               |:..|||.:    ||            |.|||      |:.
Human   348 ATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTGCPARIQAFKVQTTLMLCEK 412

  Fly   397 QSQRHWSLVDVSGNNRAALPTTKI----------------RQVSAQRNQNKT---SGPWTMGFAE 442
            .|:.......:|.:....:|..::                |.|.|:|..|.|   ||  .:||
Human   413 DSRSTKGFPSISYSGFLLIPLNRLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSG--IVGF-- 473

  Fly   443 TPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKDS 503
               :..|.|                         ...|..|.::.:|:.||..:...:.||
Human   474 ---NAFCSK-------------------------HASGEGAMKIVNLLNDLYTRFDTLTDS 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566	6/20 (30%)
		leucine-rich repeat	210..230	CDD:275380
		leucine-rich repeat	232..255	CDD:275380	3/9 (33%)
		LRR_RI	<256..410	CDD:238064	44/196 (22%)
		leucine-rich repeat	256..276	CDD:275380	6/19 (32%)
		LRR_8	279..359	CDD:290566	19/81 (23%)
		leucine-rich repeat	280..303	CDD:275380	4/24 (17%)
		leucine-rich repeat	304..348	CDD:275380	12/43 (28%)
		leucine-rich repeat	349..372	CDD:275380	5/26 (19%)
		PP2Cc	461..655	CDD:294085	7/43 (16%)
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:311572
		HNOBA	207..449	CDD:311573	48/230 (21%)
		Guanylate_cyc	455..648	CDD:306677	18/84 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900