DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and GUCY1A1

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_000847.2 Gene:GUCY1A1 / 2982 HGNCID:4685 Length:690 Species:Homo sapiens


Alignment Length:713 Identity:130/713 - (18%)
Similarity:230/713 - (32%) Gaps:255/713 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   373 LKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRN------QNK 431
            ||.|.::|       |..|.:.......:.|..:.:|::.:...|..|.|...::|      |.|
Human     6 LKDLKITG-------ECPFSLLAPGQVPNESSEEAAGSSESCKATVPICQDIPEKNIQESLPQRK 63

  Fly   432 TSGPWTMGFAETPGSGDCR-------KLSVYQLRAANYGGSDEALYGMFEALEGRGR-------A 482
            ||.  :..:..|.....|:       :|:|...|..       |.:.:.|:.:...|       |
Human    64 TSR--SRVYLHTLAESICKLIFPEFERLNVALQRTL-------AKHKIKESRKSLEREDFEKTIA 119

  Fly   483 AQEMSHLVP-DLMKQ---EQMVK-------------DSAVRDYMK--FTLLAAQQQC------GS 522
            .|.::..|| :::|:   |::.|             ...::|::.  .|||.....|      |.
Human   120 EQAVAAGVPVEVIKESLGEEVFKICYEEDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGR 184

  Fly   523 VRSAALFHLTR------------TRAPSKVRP--LKSKRYVL---------------RMASTGGL 558
            :..|::..|.:            .|..|.:.|  :|:..:||               ...|....
Human   185 LEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETEVEVSLMPPCFHNDCSEFVN 249

  Fly   559 DAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVL-------ELILSNDDEYLVVGNAQLWSVMDID 616
            ..||: .:..::.|||.:.......|:..|..|       ..:...|...|..||. :..:|:  
Human   250 QPYLL-YSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFGNG-IRRLMN-- 310

  Fly   617 RAAREIRKEEN-----SLLAAKRLVDIAQSFAAAESL--SVIVVRFRHLGTDVDHLIRELKQSVR 674
              .|:.:.:.|     .:|..|    |.|:|:...::  ...|||.|..    |:.:::..:.:.
Human   311 --RRDFQGKPNFEEYFEILTPK----INQTFSGIMTMLNMQFVVRVRRW----DNSVKKSSRVMD 365

  Fly   675 KKPQPVSLPLSS-----GSVCKRTCCDR-----------SNACRHRAIEQEPLAGRSSPSGQSDR 723
            .|.|.:.:..||     ||    .|.||           |:...|.|:....|.|..:.:....:
Human   366 LKGQMIYIVESSAILFLGS----PCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLK 426

  Fly   724 DLLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYMLEQ-----NTQLLFD 783
            ..|.|.|   ..|..|....||::.:.:|...|:....::::   .|:..:.|     |..:||.
Human   427 KRLGKLK---ATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQ---LWQGQVVQAKKFSNVTMLFS 485

  Fly   784 ------------------KELNTISKSFTKQ---------RTVPNAIMAATVLPERND------- 814
                              ..||.:...|.:|         .|:.:|...|..|.:.:|       
Human   486 DIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIA 550

  Fly   815 ----------------------------------------------FTSNLMRTVTNKFISTSTP 833
                                                          |.:|:  |:.|||.|.|.|
Human   551 LMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNV--TLANKFESCSVP 613

  Fly   834 QLPQPITTSVPLGSYHQVKQAP------------PGHFGSAL----SFQQAHSYGYNLFDAKP 880
            :     ..:|...:|..:|..|            |.:|.|.:    .|..|:..|.|   :||
Human   614 R-----KINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSEIPGICHFLDAYQQGTN---SKP 668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380
leucine-rich repeat 184..209 CDD:275380
LRR_8 205..266 CDD:290566
leucine-rich repeat 210..230 CDD:275380
leucine-rich repeat 232..255 CDD:275380
LRR_RI <256..410 CDD:238064 7/36 (19%)
leucine-rich repeat 256..276 CDD:275380
LRR_8 279..359 CDD:290566
leucine-rich repeat 280..303 CDD:275380
leucine-rich repeat 304..348 CDD:275380
leucine-rich repeat 349..372 CDD:275380
PP2Cc 461..655 CDD:294085 47/268 (18%)
GUCY1A1NP_000847.2 HNOBA 277..466 CDD:400168 42/211 (20%)
Guanylate_cyc 472..643 CDD:306677 26/177 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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