DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and GUCY1A2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001243353.1	Gene:	GUCY1A2 / 2977	HGNCID:	4684	Length:	763	Species:	Homo sapiens

Alignment Length:	834	Identity:	162/834 - (19%)
Similarity:	266/834 - (31%)	Gaps:	271/834 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQAATFGQTSPQ---KLSLKGSQLGGSILIGN 66
            :|....|.:.....:|:.:.|.|.|....||   .|||.|....|   :::|  ..||.||
Human    39 SRSPPGPLEPSPAAAAAAAAPAPTPAASAAA---AAATAGARRVQRRRRVNL--DSLGESI---- 94

  Fly    67 YNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHP 131
                       :.:......::.|  |||.:.......:|...:     |:.|: ||||...::
Human    95 -----------SRLTAPSPQTIQQ--TLKRTLQYYEHQVIGYRD-----AEKNF-HNISNRCSY- 139

  Fly   132 VPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQ 196
                     ..|:|..|:.: |......||         |:              |.|.:.::::
Human   140 ---------ADHSNKEEIED-VSGILQCTA---------NI--------------LGLKFEEIQK 171

  Fly   197 LDQFPEGFSSI------RSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAA 255
              :|.|.|.:|      |.|:.....|    .:||....|.||.:..|..|.:||      ...:
Human   172 --RFGEEFFNICFHENERVLRAVGGTL----QDFFNGFDALLEHIRTSFGKQATL------ESPS 224

  Fly   256 LVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWP-ELEILVLSGNMLQQLPE 319
            .:...|....|....|.|.|        .:.:..:|::.||..:.:. ::|:..::.   ::|..
Human   225 FLCKELPEGTLMLHYFHPHH--------IVGFAMLGMIKAAGKKIYRLDVEVEQVAN---EKLCS 278

  Fly   320 EVATLGQLRVL-----RCCN-NLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDL 378
            :|:..|....|     .|.| |::...|| ....:...|.:|.|...|.....|:...::..|.|
Human   279 DVSNPGNCSCLTFLIKECENTNIMKNLPQ-GTSQVPADLRISINTFCRAFPFHLMFDPSMSVLQL 342

  Fly   379 SGNL--QLQVDEQ---QFKVCQSQSQRHWSLVDVSGNN-------RAALP---TTKIRQVSAQRN 428
            ...|  ||:.|..   :|:.|       :.:|....|.       |.:.|   .|| .:.|...|
Human   343 GEGLRKQLRCDTHKVLKFEDC-------FEIVSPKVNATFERVLLRLSTPFVIRTK-PEASGSEN 399

  Fly   429 QNKT-------------------SGPWTMGFAETPGSG----------DCRKLSVYQLRAANYGG 464
            ::|.                   ..|......|..|.|          ..|.:.:...:|....|
Human   400 KDKVMEVKGQMIHVPESNSILFLGSPCVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQDG 464

  Fly   465 SDEALYGMFEALEGRGRAAQEMSHLVPDLM---------------KQEQMVKDSAV----RDYMK 510
            ..:.:..:...||...:|.:|......||:               :|.|..|...|    .|.:.
Human   465 LKKRMDKLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVG 529

  Fly   511 FTLLAAQ------------------QQCG--------------------------SVRSAALFHL 531
            ||.:.||                  .|||                          ..:..||..|
Human   530 FTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMAL 594

  Fly   532 TRTRAPSKV-----RPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTKPDVIQKDQIHSMPDPHVL 591
            .......:|     ||::.:|                   |:|..:.|..||     .:||.|..
Human   595 KMMELSEEVLTPDGRPIQPQR-------------------SELLFSFPVSIQ-----LVPDQHQS 635

  Fly   592 ELILSNDDEYLVVG---NAQLWSVMDIDRAAREIRKEENSLLAAK-------RLVDIA----QSF 642
            |..|..  |.:.:|   .:.|..|:.: |..|......|..||:|       |.::::    |..
Human   636 ETDLGT--EKMRIGIHSGSVLAGVVGV-RMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLL 697

  Fly   643 AAAESLSVIVVRFRHLGTDVDHLIRELK-----QSVRKKPQPVSLPLSSGSVCK 691
            ...||.:.|......|   .|:..:|:.     ..||..|:|....|||..:.|
Human   698 KREESFTFIPRSREEL---PDNFPKEIPGICYFLEVRTGPKPPKPSLSSSRIKK 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/18 (22%)
		LRR_8	109..169	CDD:290566	12/59 (20%)
		leucine-rich repeat	111..135	CDD:275380	6/23 (26%)
		leucine-rich repeat	136..158	CDD:275380	4/21 (19%)
		leucine-rich repeat	159..183	CDD:275380	3/23 (13%)
		leucine-rich repeat	184..209	CDD:275380	6/30 (20%)
		LRR_8	205..266	CDD:290566	14/66 (21%)
		leucine-rich repeat	210..230	CDD:275380	4/19 (21%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	32/165 (19%)
		leucine-rich repeat	256..276	CDD:275380	4/19 (21%)
		LRR_8	279..359	CDD:290566	16/86 (19%)
		leucine-rich repeat	280..303	CDD:275380	3/23 (13%)
		leucine-rich repeat	304..348	CDD:275380	10/49 (20%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	51/275 (19%)
GUCY1A2	NP_001243353.1	HNOB	<159..270	CDD:285002	29/153 (19%)
		HNOBA	316..503	CDD:285003	35/194 (18%)
		CYCc	485..705	CDD:214485	46/246 (19%)
		Guanylate_cyc	514..729	CDD:278633	45/244 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900