DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Lrrd1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_216085.3	Gene:	Lrrd1 / 296836	RGDID:	1562785	Length:	855	Species:	Rattus norvegicus

Alignment Length:	729	Identity:	156/729 - (21%)
Similarity:	293/729 - (40%)	Gaps:	174/729 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KQADPYKSKLKVSASHSGPHPLPVEVTAA--------EEEQAATFGQTSP------QKLSLKGSQ 57
            |..|.......|.....|....||::...        ::.|..||....|      :.|||:.:.
  Rat   131 KGFDMESDTFTVHLDAKGLQEFPVDIVKVKYVKYLYLDKNQIKTFQGADPGDLLGLETLSLQENG 195

  Fly    58 LGG-----------SILIGNYNYLT-------------QLEVCENEMEVL--DLSSLAQLETLKC 96
            |..           .:|..:||.::             ||.:..|.:|.|  .|.:|..||||..
  Rat   196 LSSIPQEIQLFHNLKVLNASYNEISHIPKELLQLGNMRQLFLNSNHIESLPSGLENLRYLETLSL 260

  Fly    97 SRNKLMEL---IINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSELPNWVGACAS 158
            .:|:|..:   :....||:||..::|.| .|.:.:...:| ||..::::.|....||..|....:
  Rat   261 GKNRLTHIPDSLCGLKNLKTLNLEYNQL-TIFSKSLCFLP-KLVSLNLTGNMIGSLPKEVRELKN 323

  Fly   159 LTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDN 223
            |..:..:||:|..:||.:  :::.::..|.||.|.|:.:....|.|..:|.|.|.:|.|.|||..
  Rat   324 LENLLMNHNKLTFLAVEI--FQLLKIKELHLADNKLEAISPKIENFKELRLLNLDNNLLQSLPKK 386

  Fly   224 FFAVTH-ARLETLNVSCNKLSTLPR---------------------YEQNNHAALV-NLSLAGNH 265
               ::| ..||:|.:|.|.|..||:                     .|:.:|.:.: :|..:||.
  Rat   387 ---ISHCVNLESLTLSDNNLEELPKKIRKLKNLRQLHANRNKMIKMAEEISHLSKIHSLEFSGNQ 448

  Fly   266 LNDSIFEPLHNAAKLRVLHLAYNRIGVLPAA-CVRNWPELEILVLSGNMLQQLPEEVATLGQLRV 329
            :.....| :.|..::..:.|.||.|...|.. |...  .|:.|..:||.:.::|.:::...||..
  Rat   449 ITHVPIE-IKNCKEITRVELNYNNIMYFPVGLCALQ--SLDYLSFNGNYISEIPVDLSFSKQLLH 510

  Fly   330 LRC-CNNLLLCTPQLAKLAMLKVLDLSHNHLDRVN--LLALVPSRNLKYLDLSGNLQLQVDEQQF 391
            |.. .|.:.:.:..|..|..|:.|||:.|.:.::.  :.|::   :|..|.||.|        :|
  Rat   511 LELNKNKITIFSEHLCSLTNLEYLDLAKNQIRKIPHCISAML---SLHVLILSDN--------KF 564

  Fly   392 KVCQSQ--SQRHWSLVDVSGNNRAALPT--TKIRQVSAQR--NQNKTSGPWTMGFAETPGSGDCR 450
            ::...:  |.::..|:|:|.|....:|:  :|::::....  |.|.|..|     ||.     |:
  Rat   565 EIFPKELCSLKNLQLLDISENQLHKIPSEISKLKKIQKLNLSNNNFTHFP-----AEL-----CQ 619

  Fly   451 KLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQM----VKDSAVRDYMKF 511
            ..::..|..:...|                   ::::.|..::.:..|:    :.::|:::
  Rat   620 LQTLEDLNISQISG-------------------KKLTRLPEEVSRMTQLKALNISNNAIKE---- 661

  Fly   512 TLLAAQQQCGSVRSAALFHLTRTR---APSKVRPLKSKRYVLRMASTGGLD----AYLIRRTSQL 569
                ..:..|.:|:...||.:..:   .||....|.    ||:....||.:    ...|.:.|.|
  Rat   662 ----IPRNIGELRNLITFHASNNQINSLPSSFLSLN----VLQSLDLGGNNLTDLPSAIYKLSSL 718

  Fly   570 R--------LTKP--DVIQKDQIHSMP---------DPHVLELILSNDDEYLVVGNAQLWSVMDI 615
            :        |.:|  ::.:..|:|::.         |..:||.|      :.:|.|....:..:.
  Rat   719 KEINFDDNPLLRPPMEICKGKQMHTITCYLQRADDRDEKILEKI------FHIVANNITETKFEF 777

  Fly   616 DRAAREIRKEENSL 629
            .:....:.:.|||:
  Rat   778 LQQKLHMARSENSV 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/21 (29%)
		LRR_8	109..169	CDD:290566	17/59 (29%)
		leucine-rich repeat	111..135	CDD:275380	7/23 (30%)
		leucine-rich repeat	136..158	CDD:275380	5/21 (24%)
		leucine-rich repeat	159..183	CDD:275380	6/23 (26%)
		leucine-rich repeat	184..209	CDD:275380	7/24 (29%)
		LRR_8	205..266	CDD:290566	22/83 (27%)
		leucine-rich repeat	210..230	CDD:275380	8/20 (40%)
		leucine-rich repeat	232..255	CDD:275380	10/43 (23%)
		LRR_RI	<256..410	CDD:238064	38/160 (24%)
		leucine-rich repeat	256..276	CDD:275380	4/20 (20%)
		LRR_8	279..359	CDD:290566	22/81 (27%)
		leucine-rich repeat	280..303	CDD:275380	6/23 (26%)
		leucine-rich repeat	304..348	CDD:275380	11/44 (25%)
		leucine-rich repeat	349..372	CDD:275380	6/24 (25%)
		PP2Cc	461..655	CDD:294085	31/199 (16%)
Lrrd1	XP_216085.3	leucine-rich repeat	162..185	CDD:275380	4/22 (18%)
		LRR_8	185..242	CDD:290566	10/56 (18%)
		leucine-rich repeat	186..208	CDD:275380	4/21 (19%)
		leucine-rich repeat	209..231	CDD:275380	3/21 (14%)
		leucine-rich repeat	232..254	CDD:275380	7/21 (33%)
		LRR_RI	253..564	CDD:238064	85/331 (26%)
		LRR_8	253..311	CDD:290566	17/59 (29%)
		leucine-rich repeat	255..277	CDD:275380	6/21 (29%)
		leucine-rich repeat	278..300	CDD:275380	7/23 (30%)
		LRR_8	299..357	CDD:290566	17/60 (28%)
		leucine-rich repeat	301..323	CDD:275380	5/21 (24%)
		leucine-rich repeat	324..346	CDD:275380	6/23 (26%)
		leucine-rich repeat	347..392	CDD:275380	16/47 (34%)
		leucine-rich repeat	439..461	CDD:275380	5/22 (23%)
		leucine-rich repeat	463..484	CDD:275380	6/22 (27%)
		leucine-rich repeat	487..507	CDD:275380	4/19 (21%)
		leucine-rich repeat	508..530	CDD:275380	5/21 (24%)
		leucine-rich repeat	531..553	CDD:275380	6/24 (25%)
		LRR_RI	537..>728	CDD:238064	41/242 (17%)
		LRR_8	553..610	CDD:290566	14/64 (22%)
		leucine-rich repeat	554..576	CDD:275380	7/29 (24%)
		leucine-rich repeat	577..599	CDD:275380	6/21 (29%)
		leucine-rich repeat	600..648	CDD:275380	10/76 (13%)
		leucine-rich repeat	649..671	CDD:275380	2/29 (7%)
		LRR_8	670..728	CDD:290566	13/61 (21%)
		leucine-rich repeat	672..694	CDD:275380	5/25 (20%)
		leucine-rich repeat	695..717	CDD:275380	4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910