DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Adcy8

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_058838.1	Gene:	Adcy8 / 29241	RGDID:	2036	Length:	1248	Species:	Rattus norvegicus

Alignment Length:	629	Identity:	124/629 - (19%)
Similarity:	205/629 - (32%)	Gaps:	218/629 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TRKQADPYKSKLKVSASHSGPH-----PLPVEVTAAEEEQAATFGQTS--PQKL---SLKGSQLG 59
            :||.::|..|    ..:|..|.     .||: .:....|:|...|.|.  |::.   |..||..|
  Rat    62 SRKASNPAGS----GPNHHAPQLSSDSVLPL-YSLGSGERAHNTGGTKVFPERSGSGSASGSGGG 121

  Fly    60 GSI---------------LIGNYNYLTQL-EVCENEMEVLDLSSLAQLETLKCSRNKLMELIING 108
            |.:               |.|.|:|...: ....|..:..||..|.|...|  .:.:..|:::|.
  Rat   122 GDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFL--GQRRKSEVVMNV 184

  Fly   109 ----TNLQTLVADHNYLHNISTTNTHPVPLK-------------------LQRIDISHN--NFSE 148
                |.|..||     || :|..:....|||                   :::...||.  .:|.
  Rat   185 LDVLTKLTLLV-----LH-LSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSG 243

  Fly   149 LPNWVGACASLTAINASHNRLNNVA--VLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIR-SL 210
            :..||.....:.|....:..|.:..  ||...:....::.|.|.:..|..|     |.|.:: :|
  Rat   244 VVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGL-----GTSLLQVTL 303

  Fly   211 QLQSNELPSLPDN--------FFAVTHA---------------------------RLETLNVSCN 240
            |:....|.....|        |..:..|                           ||||.|....
  Rat   304 QVLIPRLAVFSINQVLAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQE 368

  Fly   241 K--LSTLPRYEQNNHAALVNLSLAGNHLN---DSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRN 300
            :  ||.|||:        |.|.:..:..|   :.:....|     |:....|..:.:| .|.|:.
  Rat   369 RLVLSVLPRF--------VVLEMINDMTNVEDEHLQHQFH-----RIYIHRYENVSIL-FADVKG 419

  Fly   301 WPELEILVLSGNMLQQLPEEVATLGQL---------RVLRCCNNLLLCTPQLAKLAMLKVLDLSH 356
            :..|...:.:..:::.|.|..|...:|         ::|..|...:...|:..:         .|
  Rat   420 FTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQ---------DH 475

  Fly   357 NH------LDRVNLLALVPSRNLKYLDL-----SGNL---QLQVDEQQFKVCQSQSQRHWSL-VD 406
            .|      |..:..:..|.||....:|:     ||::   .|.:.:.||.|        ||. ||
  Rat   476 AHCCVEMGLSMIKTIRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDV--------WSWDVD 532

  Fly   407 VSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYG 471
            ::                   |:.::.|        .||.....|.::            :.|.|
  Rat   533 IA-------------------NKLESGG--------IPGRIHISKATL------------DCLSG 558

  Fly   472 MFEALEGRGRAAQEM--SHLVPD-LMKQ---------EQMVKDS 503
            .:...||.|:...|.  .|.:.. |:||         |.:||:|
  Rat   559 DYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPEDIVKES 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/22 (14%)
		LRR_8	109..169	CDD:290566	16/80 (20%)
		leucine-rich repeat	111..135	CDD:275380	7/23 (30%)
		leucine-rich repeat	136..158	CDD:275380	5/23 (22%)
		leucine-rich repeat	159..183	CDD:275380	4/25 (16%)
		leucine-rich repeat	184..209	CDD:275380	6/25 (24%)
		LRR_8	205..266	CDD:290566	19/98 (19%)
		leucine-rich repeat	210..230	CDD:275380	5/27 (19%)
		leucine-rich repeat	232..255	CDD:275380	9/24 (38%)
		LRR_RI	<256..410	CDD:238064	34/180 (19%)
		leucine-rich repeat	256..276	CDD:275380	3/22 (14%)
		LRR_8	279..359	CDD:290566	15/94 (16%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	8/52 (15%)
		leucine-rich repeat	349..372	CDD:275380	5/28 (18%)
		PP2Cc	461..655	CDD:294085	14/55 (25%)
Adcy8	NP_058838.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269\|PubMed:16258073, ECO:0000269\|PubMed:22494970, ECO:0000269\|PubMed:22976297	1..179		28/123 (23%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269\|PubMed:22976297	1..106		12/48 (25%)
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	49..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	51..117		14/59 (24%)
		AC_N	<158..397	CDD:292831	51/259 (20%)
		CYCc	363..561	CDD:214485	47/267 (18%)
		Guanylate_cyc	402..586	CDD:278633	42/240 (18%)
		DUF1053	614..708	CDD:283888
		CYCc	941..1145	CDD:214485
		Guanylate_cyc	970..1169	CDD:278633
		Involved in CALM1 interaction. /evidence=ECO:0000269\|PubMed:16258073	1106..1248
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269\|PubMed:19305019	1197..1212
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1220..1248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900