DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Flii

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001008280.1	Gene:	Flii / 287375	RGDID:	1307590	Length:	1270	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	116/501 - (23%)
Similarity:	203/501 - (40%)	Gaps:	117/501 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LSLKGSQLGGSILIGNYNYLTQLEVCENEMEVL-----DLSSLAQLETLKCSRNKLMEL---IIN 107
            :.|.|:...|.....|...:|.|...:.....|     :|::|.:||.|..|.|.|..|   :.:
  Rat    13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSS 77

  Fly   108 GTNLQTLVADHNYLHNISTTNTHPVP---LKLQR---IDISHNNFSELPNWVGACASLTAINASH 166
            ..:|:.:||..|.|.|..      ||   .||..   :|:|||..:|.|..:....::..:|.||
  Rat    78 LPSLRAIVARANSLKNSG------VPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSH 136

  Fly   167 NRLNNVAVLLRNYRITELVSLDLAYNDLK-------------------------QLDQFPEGFSS 206
            |.::::...| ...:|:|:.|||:.|.|:                         ||.|.| ...:
  Rat   137 NSIDSIPNQL-FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLP-AMMA 199

  Fly   207 IRSLQLQSNE--LPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDS 269
            :::|.|::.:  ..:||.:...:::  |..:::|||.|:.:|
  Rat   200 LQTLHLRNTQRTQSNLPTSLEGLSN--LSDVDLSCNDLTRVP----------------------- 239

  Fly   270 IFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCN 334
              |.|:....|..|:|:.|:|..| :.|:..|..||.|.||.|.|..||..:..|.:|:.|...:
  Rat   240 --ECLYTLPNLHRLNLSSNQIAEL-SLCIDQWVHLETLNLSRNQLTSLPSAICKLTKLKKLYLNS 301

  Fly   335 NLL---LCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSR-----NLKYLDLSGNLQLQVDEQQF 391
            |.|   .....:.||..|:....::|:|:      |:|..     .|:.|.|:.|..:.:.|...
  Rat   302 NKLDFDGLPSGIGKLTSLEEFMAANNNLE------LIPESLCRCPKLRKLVLNKNRLVTLPEAIH 360

  Fly   392 KVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVS-------AQRNQNKTSG--PWTMGFAETPGSG 447
            .:.:.:      ::||..|....:|.......:       :.:||.:.:|  |.|:..|...|||
  Rat   361 FLTEIE------VLDVRENPSLVMPPKPADHTAEWYNIDFSLQNQLRLAGASPATVAAAAAVGSG 419

  Fly   448 D----CRKLSVYQLRAANYGGSD----EALYGMFEALEGRGRAAQE 485
            .    .||:   :||.......|    :.|.||.:..:.:.:..:|
  Rat   420 SKDPLARKM---RLRRRKDSAQDVQAKQVLKGMSDVAQEKNKNQEE 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/21 (33%)
		LRR_8	109..169	CDD:290566	20/65 (31%)
		leucine-rich repeat	111..135	CDD:275380	8/26 (31%)
		leucine-rich repeat	136..158	CDD:275380	7/24 (29%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	10/49 (20%)
		LRR_8	205..266	CDD:290566	10/62 (16%)
		leucine-rich repeat	210..230	CDD:275380	4/21 (19%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	38/161 (24%)
		leucine-rich repeat	256..276	CDD:275380	2/19 (11%)
		LRR_8	279..359	CDD:290566	26/82 (32%)
		leucine-rich repeat	280..303	CDD:275380	8/22 (36%)
		leucine-rich repeat	304..348	CDD:275380	16/46 (35%)
		leucine-rich repeat	349..372	CDD:275380	5/27 (19%)
		PP2Cc	461..655	CDD:294085	5/29 (17%)
Flii	NP_001008280.1	LRR_RI	<2..139	CDD:238064	36/131 (27%)
		leucine-rich repeat	10..34	CDD:275380	4/20 (20%)
		LRR_8	33..91	CDD:290566	16/57 (28%)
		leucine-rich repeat	35..57	CDD:275380	4/21 (19%)
		leucine-rich repeat	58..80	CDD:275380	7/21 (33%)
		leucine-rich repeat	83..105	CDD:275380	9/27 (33%)
		LRR_RI	89..375	CDD:238064	78/333 (23%)
		leucine-rich repeat	106..128	CDD:275380	6/21 (29%)
		leucine-rich repeat	129..152	CDD:275380	5/23 (22%)
		LRR_8	131..186	CDD:290566	12/55 (22%)
		leucine-rich repeat	153..175	CDD:275380	6/21 (29%)
		leucine-rich repeat	176..199	CDD:275380	4/23 (17%)
		leucine-rich repeat	200..224	CDD:275380	4/23 (17%)
		LRR_8	223..281	CDD:290566	22/85 (26%)
		leucine-rich repeat	225..247	CDD:275380	8/46 (17%)
		leucine-rich repeat	248..270	CDD:275380	8/22 (36%)
		LRR_8	270..352	CDD:290566	25/87 (29%)
		leucine-rich repeat	271..318	CDD:275380	16/46 (35%)
		leucine-rich repeat	319..341	CDD:275380	5/27 (19%)
		gelsolin_S1_like	492..604	CDD:200446
		gelsolin_like	619..703	CDD:200436
		gelsolin_S3_like	723..837	CDD:200448
		gelsolin_like	<976..1036	CDD:200436
		gelsolin_S5_like	1054..1153	CDD:200444
		gelsolin_S6_like	1164..1263	CDD:200447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910