DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Adcy10

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_766617.2	Gene:	Adcy10 / 271639	MGIID:	2660854	Length:	1614	Species:	Mus musculus

Alignment Length:	904	Identity:	158/904 - (17%)
Similarity:	294/904 - (32%)	Gaps:	336/904 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 ENEMEVLDLSSLAQLETLKCSRNKLMELI-----INGTN---LQTLVADHNYLHNISTTNTHPVP 133
            :.::|.|.:..|||  |::  ..:::.:|     ::||:   ::.|:              ..:|
Mouse   620 QKQLEALFMKILAQ--TVR--EERIIFIIDEAQFVDGTSWAFIEKLI--------------RSMP 666

  Fly   134 LKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLDLAYNDL-KQL 197
            :   .|.:|...|||:|     ||:..||..:.|........::...|.:.|.:||:.:.: ::|
Mouse   667 I---FIVMSLAPFSEVP-----CAAANAIMKNRNTTYITLGTMQPQEIRDKVCVDLSVSSIPREL 723

  Fly   198 DQF-PEGFSSIRSLQLQSNELPSLPDNFFAVTHARLET---LNVSCN---KLSTLPRYEQNNHAA 255
            |.: .||...|   .....||....|:...:...:.||   .||:.|   |.|..|..:.....:
Mouse   724 DSYLVEGSCGI---PYYCEELLKNLDHHRVLLFQQAETEQKTNVTWNNMFKHSVRPTDDMQLFTS 785

  Fly   256 L------VNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNML 314
            :      |...::|..||:     |...|.|:.:.|.                :|:.:.||..||
Mouse   786 ISEGQKEVCYLVSGVRLNN-----LSPPASLKEISLV----------------QLDSMSLSHQML 829

  Fly   315 QQLPEEVATLGQLRVLRCCNNL-LLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDL 378
                           :||...: |..|.:|                    |..::|..|:|.:..
Mouse   830 ---------------VRCAAIIGLTFTTEL--------------------LFEILPCWNMKMMIK 859

  Fly   379 SGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAET 443
            :  |...|:...|...:|......:|       :..:||.::..
Mouse   860 A--LATLVESNVFNCFRSSKDLQLAL-------KQNVPTFEVHY--------------------- 894

  Fly   444 PGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMK--QEQMVKDSAVR 506
                  |.|::.......||..:|     ...:||.....:.:....|.:.|  .|..:||.
Mouse   895 ------RSLALKLKEGLTYGEEEE-----LREMEGEVVECRILRFCRPIMQKTAYELWLKDQ--- 945

  Fly   507 DYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRL 571
                                           .||..||..|::...|          .|.:..|
Mouse   946 -------------------------------KKVLHLKCARFLEESA----------HRCNHCR- 968

  Fly   572 TKPDVIQKDQIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRK------EENSLL 630
                     .:..:|..|.:..|..|              .:|:|...|.:..      ||.::.
Mouse   969 ---------NVDFIPYHHFIVDIRLN--------------TLDMDTVKRMVTSQGFKIDEEEAIF 1010

  Fly   631 AAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCC 695
            :..   ::.:.:...|:||:..:|.:.|.. .|::|.::|.|    |..: :||.|
Mouse  1011 SKS---ELPRKYKFPENLSITEIREKILHF-FDNVILKMKSS----PNDI-IPLES--------- 1057

  Fly   696 DRSNACRHRAIEQ---EPLAGRSSPSGQSDRDLLAKDKDDEFV-----LAHA-RVLQEEQQLEM- 750
                 |:.:.:.|   .|||          :..:|.:::::.:     ||.| .:|.:.....|
Mouse  1058 -----CQCKELLQIVILPLA----------QHFVALEENNKALYYFLELASAYLILGDNYNAYMY 1107

  Fly   751 LDETESVSESVLSEEQFKCWEYMLEQNT------QLLFDKELNTISKSFTKQ------RTVPNAI 803
            |.|.|.:.:|:.:|:.   |....|..|      ::.|:.....::|...::      |..|..:
Mouse  1108 LGEGERLLKSLTNEDS---WSQTFEYATFYSLKAEVCFNMGQMVLAKKMLRKALKLLNRMFPCNL 1169

  Fly   804 MAATVLPERNDFTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQAPPGHFGSALSFQQA 868
            :..|       |..::.:...:.|::..|.:           ||.       ||...:.|..|.:
Mouse  1170 LTLT-------FQMHVEKNRLSHFMNQHTQE-----------GSV-------PGKKLAQLYLQAS 1209

  Fly   869 ------HSYGYNLFDAKPRPKFHGGTVKRSAGPNSAYFGSLQRLMPYN----FEYDFAV 917
                  ..|..|.|       ||           ..|:|.|..:|..|    .:.||.:
Mouse  1210 CFSLLWRIYSLNFF-------FH-----------YKYYGHLAAMMEMNTSLETQNDFQI 1250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	3/23 (13%)
		LRR_8	109..169	CDD:290566	14/62 (23%)
		leucine-rich repeat	111..135	CDD:275380	2/23 (9%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	4/23 (17%)
		leucine-rich repeat	184..209	CDD:275380	8/26 (31%)
		LRR_8	205..266	CDD:290566	14/72 (19%)
		leucine-rich repeat	210..230	CDD:275380	3/19 (16%)
		leucine-rich repeat	232..255	CDD:275380	8/28 (29%)
		LRR_RI	<256..410	CDD:238064	27/160 (17%)
		leucine-rich repeat	256..276	CDD:275380	5/25 (20%)
		LRR_8	279..359	CDD:290566	12/80 (15%)
		leucine-rich repeat	280..303	CDD:275380	2/22 (9%)
		leucine-rich repeat	304..348	CDD:275380	10/44 (23%)
		leucine-rich repeat	349..372	CDD:275380	2/22 (9%)
		PP2Cc	461..655	CDD:294085	30/201 (15%)
Adcy10	NP_766617.2	CHD	40..214	CDD:143636
		CHD	292..461	CDD:143636
		COG3899	485..>959	CDD:226415	88/498 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900