DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and Gucy2c

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_037302.1	Gene:	Gucy2c / 25711	RGDID:	2771	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	839	Identity:	162/839 - (19%)
Similarity:	290/839 - (34%)	Gaps:	244/839 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 KLMELI-----INGTNLQTLVADHNYLHNISTTNTHPVPL--KLQRIDISHNNFSELPNW---VG 154
            |||..:     :|....:|...:.:|::.   ..:.|...  .|..::...:.|||:.::   :.
  Rat   165 KLMYFLVDFWKVNNAPFKTFSWNSSYVYK---NGSEPEDCFWYLNALEAGVSYFSEVLSFKDVLR 226

  Fly   155 ACASLTAINASHNRLNNVAVLLRN----YRI---------TELVSLDLAYNDLKQLD-QFPEGFS 205
            .......|....||.:||.|:...    |.:         |.::.:||..|...:.| :.||...
  Rat   227 RSEQFQEILMGRNRKSNVIVMCGTPETFYNVKGDLKVADDTVVILVDLFSNHYFEDDTRAPEYMD 291

  Fly   206 SIRSLQLQ----------SNELPSLPDNFFAVTHARLETLNVSCNKLSTL---------PRYEQN 251
            ::..|.|.          |...||...:|   :.|.||...:..:.|.|.         |::.:
  Rat   292 NVLVLTLPPEKFIANASVSGRFPSERSDF---SLAYLEGTLLFGHMLQTFLENGESVTTPKFAR- 352

  Fly   252 NHAALVNLSLAGNH----LNDS---------IFEPLHNAAKLRVLHLAY--NRIGVLPAACVRN- 300
               |..||:..|..    |:||         ::..| :..|.:|| :||  ::...:|.|...|
  Rat   353 ---AFRNLTFQGLEGPVTLDDSGDIDNIMCLLYVSL-DTRKYKVL-MAYDTHKNQTIPVATSPNF 412

  Fly   301 -WPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNL 364
             |..           .:||.:|..||...::.....|......|..:|:|.:.....:|..|...
  Rat   413 IWKN-----------HRLPNDVPGLGPQILMIAVFTLTGIVVVLLLIALLVLRKYRRDHELRQKK 466

  Fly   365 LALVPSRNLKYLDL--SGNLQLQVDE-------QQFKVCQSQSQ-------RHWSLVDVSGNNRA 413
            .:.:||.|:..|:.  :.::.|::|:       |:.:.|:...:       :|   .|.:.:.:.
  Rat   467 WSHIPSENIFPLETNETNHVSLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKH---CDGNFSEKQ 528

  Fly   414 ALPTTKIRQVSAQRNQNKTSGPWTM-----GFAETPGSGDCRKLSVYQLRAANYGGSDEALY--G 471
            .:...|:.| |...|..|..|...:     |..|....|..|::.           :|...|  |
  Rat   529 KIELNKLLQ-SDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVL-----------NDTISYPDG 581

  Fly   472 MFEALEGR----GRAAQEMSHL------VPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSA 526
            .|...|.:    ...|:.||:|      |...:|....|.||  |..:|.|...    |.|:
  Rat   582 TFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDS--RMVVKITDFG----CNSI--- 637

  Fly   527 ALFHLTRTRAPSKVRPLKSKRYVLRMA--STGGLDAY---------LIRRTSQLRLTKPDVIQKD 580
                     .|.| :.|.:....||.|  |..| |.|         ::|:.:...|:..|  |.:
  Rat   638 ---------LPPK-KDLWTAPEHLRQATISQKG-DVYSFSIIAQEIILRKETFYTLSCRD--QNE 689

  Fly   581 QIHSMPD-----PHVLELILSNDDE-----YLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRL 635
            :|..:.:     |...:|.|...||     ||:|.:.  |   :.|...|...|:..|.||  ::
  Rat   690 KIFRVENSYGTKPFRPDLFLETADEKELEVYLLVKSC--W---EEDPEKRPDFKKIESTLA--KI 747

  Fly   636 VDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELKQSVRKKPQPVSLPLSSGSVCKRTCCDRSNA 700
            ..:.........:..::.|.:....:::||:.|..|..:.:
  Rat   748 FGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAE------------------------ 788

  Fly   701 CRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDD--EFVLAHARVLQEEQQLEMLDETESVSESVLS 763
                                       :|:.|  .|:|....|::..::..:: |.|...|..:.
  Rat   789 ---------------------------RDRADHLNFMLLPRLVVKSLKEKGIV-EPELYEEVTIY 825

  Fly   764 EEQFKCWEYMLEQNTQLLFDKELNTISKSFT---------KQRTVPNAIMAATVLPERN 813
            ......:..:.:.:|.:.....||.|.|||.         |..|:.:|.:.|:.||.||
  Rat   826 FSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRN 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	4/14 (29%)
		LRR_8	109..169	CDD:290566	9/64 (14%)
		leucine-rich repeat	111..135	CDD:275380	3/25 (12%)
		leucine-rich repeat	136..158	CDD:275380	4/24 (17%)
		leucine-rich repeat	159..183	CDD:275380	7/36 (19%)
		leucine-rich repeat	184..209	CDD:275380	6/25 (24%)
		LRR_8	205..266	CDD:290566	16/83 (19%)
		leucine-rich repeat	210..230	CDD:275380	6/29 (21%)
		leucine-rich repeat	232..255	CDD:275380	5/31 (16%)
		LRR_RI	<256..410	CDD:238064	37/186 (20%)
		leucine-rich repeat	256..276	CDD:275380	7/32 (22%)
		LRR_8	279..359	CDD:290566	18/83 (22%)
		leucine-rich repeat	280..303	CDD:275380	8/26 (31%)
		leucine-rich repeat	304..348	CDD:275380	7/43 (16%)
		leucine-rich repeat	349..372	CDD:275380	5/22 (23%)
		PP2Cc	461..655	CDD:294085	49/226 (22%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141	53/260 (20%)
		PKc_like	479..749	CDD:304357	65/313 (21%)
		STYKc	501..744	CDD:214568	60/284 (21%)
		CYCc	787..978	CDD:214485	23/150 (15%)
		Guanylate_cyc	814..1001	CDD:278633	18/72 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900