DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_001257640.1	Gene:	Gucy1b2 / 25206	RGDID:	2770	Length:	742	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	109/584 - (18%)
Similarity:	195/584 - (33%)	Gaps:	218/584 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 DNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLA 286
            |.:|::.|.:: |.|:|                              ||.:.:::...|:
  Rat   307 DEYFSIIHPQV-TFNIS------------------------------SICKFINSQFVLK----- 335

  Fly   287 YNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKV 351
             .|..::|.| .::.|   :|.|.|.|:           .:..|||.  :.:|:|   ||..|:.
  Rat   336 -TRKEMMPKA-RKSQP---MLKLRGQMI-----------WMESLRCM--IFMCSP---KLRSLQE 379

  Fly   352 LDLSHNHL------DRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGN 410
            |:.|..||      |....|.|:..:.|..::||  .||:..:::.:|.               :
  Rat   380 LEESKMHLSDIAPHDTTRDLILLNQQRLAEMELS--CQLEKKKEELRVL---------------S 427

  Fly   411 NRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEA 475
            |..|:            .:.||.   |:.:|..|.            ..||            :.
  Rat   428 NHLAI------------EKKKTE---TLLYAMLPE------------HVAN------------QL 453

  Fly   476 LEGRGRAAQEMSHLVPDLMKQEQMVKDSAVRDYMKFTLLAAQQQCGSVRSAALFHLTRTRAPSKV 540
            .|||..||.|.....            ....|.:.||.:.|  .|..::...:.:    ...||.
  Rat   454 KEGRKVAAGEFETCT------------ILFSDVVTFTNICA--ACEPIQIVNMLN----SMYSKF 500

  Fly   541 RPLKSKRYVLRMASTGGLDAYLI------------RRTSQ----LRLTKPDVIQ---------KD 580
            ..|.|...|.::.:.|  |||::            :|.:.    :|::..:|:.         :.
  Rat   501 DRLTSVHDVYKVETIG--DAYMVVGGVPVPVESHAQRVANFALGMRISAKEVMNPVTGEPIQIRV 563

  Fly   581 QIHSMPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAA 645
            .||:.|       :|:.     |||:......:..|......|.|.:.|.:...|...|.  .|.
  Rat   564 GIHTGP-------VLAG-----VVGDKMPRYCLFGDTVNTASRMESHGLPSKVHLSPTAH--RAL 614

  Fly   646 ESLSVIVVR-----------------FRHLGTDVDHLI---------REL---KQSVRKKPQPVS 681
            ::....:||                 .::|....|.::         :|:   ...|||.|   :
  Rat   615 KNKGFEIVRRGEIEVKGKGKMTTYFLIQNLNATEDEIMGRPSAPADGKEVCTPGNQVRKSP---A 676

  Fly   682 LPLSSG---SVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDEFVLAHARVL 742
            :|.::.   .|.|....|.||..   .:...|:|||:|....:::.  :.|:....|:|...||
  Rat   677 VPRNTDHQQQVYKGDPADASNEV---TLAGSPVAGRNSTDAVNNQP--SPDETKTSVVASGPVL 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566	6/43 (14%)
		leucine-rich repeat	210..230	CDD:275380	2/7 (29%)
		leucine-rich repeat	232..255	CDD:275380	3/22 (14%)
		LRR_RI	<256..410	CDD:238064	32/159 (20%)
		leucine-rich repeat	256..276	CDD:275380	2/19 (11%)
		LRR_8	279..359	CDD:290566	19/79 (24%)
		leucine-rich repeat	280..303	CDD:275380	4/22 (18%)
		leucine-rich repeat	304..348	CDD:275380	11/43 (26%)
		leucine-rich repeat	349..372	CDD:275380	8/28 (29%)
		PP2Cc	461..655	CDD:294085	40/235 (17%)
Gucy1b2	NP_001257640.1	HNOB	2..163	CDD:285002
		HNOBA	267..453	CDD:285003	47/258 (18%)
		CYCc	432..622	CDD:214485	44/262 (17%)
		Guanylate_cyc	459..642	CDD:278633	36/216 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900