DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Gucy1b1

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_036901.2 Gene:Gucy1b1 / 25202 RGDID:2769 Length:619 Species:Rattus norvegicus


Alignment Length:300 Identity:61/300 - (20%)
Similarity:107/300 - (35%) Gaps:95/300 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   599 DEYLVV---GNAQLWSVMDIDRAAREIRKEENSLLAAKRLV----DIAQSFAAAESLSVIVVRFR 656
            |..|||   |||       |.|...:::..:.|||:...||    ||:.....:...:|.|:|.:
  Rat   224 DRDLVVTQCGNA-------IYRVLPQLQPGKCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSK 281

  Fly   657 HLGTDVDHLIRELK------QSVRKKPQPVSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGR- 714
            ....||:.|..|.:      ..:|.|.|.:.||.:...:.         .|....:..:.|..| 
  Rat   282 EGLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSILF---------LCSPSVMNLDDLTRRG 337

  Fly   715 ----SSPSGQSDRD--LLAKDKDDEFVLAHARVLQEEQQLEMLDETESVSESVLSEEQFKCWEYM 773
                ..|...:.||  ||.:...:|:.|.        |:||:|.:...::...|.:|:.|....:
  Rat   338 LYLSDIPLHDATRDLVLLGEQFREEYKLT--------QELEILTDRLQLTLRALEDEKKKTDTLL 394

  Fly   774 LE---------------------QNTQLLFD-------------------KELNTISKSFTKQRT 798
            ..                     .|..:||.                   |.:|.::..:|:..|
  Rat   395 YSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDT 459

  Fly   799 VPNAIMAATVLPERNDFTSNLMRTVTNKFISTSTPQLPQP 838
            :.::        .:|.|... :.||.:|:::.|  .||:|
  Rat   460 LTDS--------RKNPFVYK-VETVGDKYMTVS--GLPEP 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380
leucine-rich repeat 184..209 CDD:275380
LRR_8 205..266 CDD:290566
leucine-rich repeat 210..230 CDD:275380
leucine-rich repeat 232..255 CDD:275380
LRR_RI <256..410 CDD:238064
leucine-rich repeat 256..276 CDD:275380
LRR_8 279..359 CDD:290566
leucine-rich repeat 280..303 CDD:275380
leucine-rich repeat 304..348 CDD:275380
leucine-rich repeat 349..372 CDD:275380
PP2Cc 461..655 CDD:294085 18/62 (29%)
Gucy1b1NP_036901.2 HNOB 2..166 CDD:285002
HNOBA 207..406 CDD:285003 45/205 (22%)
CYCc 385..584 CDD:214485 17/114 (15%)
Guanylate_cyc 412..605 CDD:278633 15/87 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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