DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Npr1

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_036745.1 Gene:Npr1 / 24603 RGDID:3195 Length:1057 Species:Rattus norvegicus


Alignment Length:301 Identity:52/301 - (17%)
Similarity:110/301 - (36%) Gaps:80/301 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KATRKQADPYKSKLKVSASHSGPHPLPVEVTAAEEEQAATFGQTSPQKLSLK--GSQLGGSILIG 65
            :.||.:..|::..:.:.:.......|.....|.:.::...|.|.   :|:|:  ..:...:||  
  Rat   750 RVTRGEQPPFRPSMDLQSHLEELGQLMQRCWAEDPQERPPFQQI---RLALRKFNKENSSNIL-- 809

  Fly    66 NYNYLTQLEVCENEM-EVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNT 129
             .|.|:::|...|.: |:::..:.|.||..:.:...|.:::                       .
  Rat   810 -DNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQIL-----------------------P 850

  Fly   130 HPVPLKLQRID-ISHNNFSELPNWVGACASLTAINASHNRLNNVAVL----------LRNYRITE 183
            |.|..:|:|.: :....|..:..:.......||::|....:..|.:|          :.|:.:.:
  Rat   851 HSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYK 915

  Fly   184 LVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELP----SLPD--NFFAVTHARLETLNVS---- 238
            :.::..||..:..|        .:|:.||.:.|:.    :|.|  ..|.:.|...|.|.:.    
  Rat   916 VETIGDAYMVVSGL--------PVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIH 972

  Fly   239 ----------------C---NKLSTLPRYEQNNHAALVNLS 260
                            |   :.::|..|.|.|..|..::||
  Rat   973 TGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLS 1013

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 3/18 (17%)
LRR_8 109..169 CDD:290566 8/60 (13%)
leucine-rich repeat 111..135 CDD:275380 2/23 (9%)
leucine-rich repeat 136..158 CDD:275380 3/22 (14%)
leucine-rich repeat 159..183 CDD:275380 6/33 (18%)
leucine-rich repeat 184..209 CDD:275380 3/24 (13%)
LRR_8 205..266 CDD:290566 18/85 (21%)
leucine-rich repeat 210..230 CDD:275380 6/25 (24%)
leucine-rich repeat 232..255 CDD:275380 7/45 (16%)
LRR_RI <256..410 CDD:238064 2/5 (40%)
leucine-rich repeat 256..276 CDD:275380 2/5 (40%)
LRR_8 279..359 CDD:290566
leucine-rich repeat 280..303 CDD:275380
leucine-rich repeat 304..348 CDD:275380
leucine-rich repeat 349..372 CDD:275380
PP2Cc 461..655 CDD:294085
Npr1NP_036745.1 PBP1_NPR_A 32..439 CDD:107380
ANF_receptor 50..410 CDD:279440
PK_GC-A_B 530..803 CDD:270944 9/55 (16%)
TyrKc 543..797 CDD:197581 8/49 (16%)
HNOBA <812..857 CDD:285003 10/67 (15%)
CYCc 836..1025 CDD:214485 34/209 (16%)
Guanylate_cyc 863..1049 CDD:278633 28/159 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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