DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Phlpp2

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001116066.2 Gene:Phlpp2 / 244650 MGIID:2444928 Length:1355 Species:Mus musculus


Alignment Length:1043 Identity:255/1043 - (24%)
Similarity:409/1043 - (39%) Gaps:269/1043 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 KVSASHSGPHPLPVEV----------------TAAEEE-----QAATFG---------------Q 45
            ::|.|.:|.|.||.::                ||..:|     |..:.|               .
Mouse   358 ELSLSCNGFHDLPSQIGKLLNLQTLSLDGNGLTALPDELGNLRQLTSLGISFNDFRHIPEVLEKL 422

  Fly    46 TSPQKLSLKGSQLG----GSI-----------------------LIGNYNYLTQLEVCENEMEVL 83
            |...|:::.|::|.    |::                       :.|| .::|.:::.:|::..|
Mouse   423 TMLDKVAMAGNRLEVLNLGALTRMSQVKHVDLRMNHLKTVITENMEGN-KHITHMDLRDNQLTDL 486

  Fly    84 DLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVPLKLQRIDISHNNFSE 148
            |||||..||.|.|.||:|.||.::|.:|:||.|..|   .::..|.:|||..|..:::|.|....
Mouse   487 DLSSLCSLEQLHCERNQLRELTLSGFSLRTLYASWN---RLTAVNVYPVPSLLTSLELSQNLLEC 548

  Fly   149 LPNWVGACASLTAINASHNRLNNVAVLLRNYRITELVSLD---LAYNDLKQLDQFPEGFSSIRSL 210
            :|:|......|..::.|||.|..|.:     ||...:||.   :.:|.:..|....|.. .:..|
Mouse   549 VPDWACEAKKLEILDISHNLLTEVPM-----RILSSLSLRKLMVGHNHIHVLPALVEHI-PLEVL 607

  Fly   211 QLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPR--YEQNNHAALVNLSLAGNHLNDSIFEP 273
            .:|.|.|..|||..|:.. ..|..||.|.|.|.:||.  ..:.:.:.|..|.|..|.|.|.....
Mouse   608 DIQHNTLSRLPDTLFSKA-LNLRYLNASANSLESLPSACAGEESLSVLQLLYLTSNLLTDQCIPV 671

  Fly   274 LHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLL 338
            |.....|||||||.|::...||:.:....:||.|.||||.|..:|..:|...:|..|....|.:.
Mouse   672 LVGHPHLRVLHLANNQLQTFPASKLNKLEQLEELNLSGNKLTAIPTTIANCKRLHTLVAHANNIS 736

  Fly   339 CTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWS 403
            ..|::.:|..::.:|||.|.|..:.:...:|: .|:.|||:||..|.::.:...:        :|
Mouse   737 IFPEILQLPQIQFVDLSCNDLTEILIPEALPA-TLQDLDLTGNTNLVLEHKTLDM--------FS 792

  Fly   404 LVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDCRKLSVYQLRAANYGGSDEA 468
            .:.....::..||.|         :...||..|:.|.||.  :|...||.|..|...|:.....|
Mouse   793 HITALKIDQKPLPAT---------DSAVTSTFWSHGLAEM--AGQRNKLCVSALAMDNFAEGVGA 846

  Fly   469 LYGMFEALEGRGRAAQEMSHL----VPDLMKQE-QMVKDSAVRDYMKFTLLAAQQQCG----SVR 524
            :||||:     |...:|:..|    :.|::.:| |...:..|  :|..|.|.:.::.|    .:.
Mouse   847 VYGMFD-----GDRNEELPRLLQCTMADVLLEEVQHSTNDTV--FMTNTFLVSHRKLGMAGQKLG 904

  Fly   525 SAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLTK-------PDVIQ--KD 580
            |:||....|   |....|..|  :.|.:|:.|...|.|.|....:.|:|       |:..|  ||
Mouse   905 SSALLCYIR---PDTADPTSS--FSLTVANVGMCQAVLCRGGKPVPLSKVFSLEHDPEEAQRVKD 964

  Fly   581 Q---------IHS-----------------MPDPHVLELILSNDDEYLVVGNAQLWSVMDIDRAA 619
            |         ::.                 :|.||:....|:..||.|::||..||..:....|.
Mouse   965 QKAIITEDNKVNGVTCCTRLLGCTYLYPWILPKPHIASTPLTIQDELLILGNKALWEHLSYLEAV 1029

  Fly   620 REIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDHLIRELK-------------Q 671
            ..:|..::.|.|||:|..:|||:...:::..:||   :|....:....|:.             .
Mouse  1030 NAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVV---YLNIGEEGCTCEMNGLTLPGPVGFASTA 1091

  Fly   672 SVRKKPQPVSLPLSSG---------------SVCKRTCCDRSNA--------------CR-HRA- 705
            :::..|:|.:...|||               |....|..|..|.              |. |.| 
Mouse  1092 ALKDTPKPTTPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNTVGLEASLLPRPERRCSLHPAS 1156

  Fly   706 ----IEQEPLAGRSSPSGQSDRDLLAKDKDD----EFVLAHARVLQEEQQLEML--DETESV--- 757
                .:::|.....| |.|||..|   |.||    |.|:.:...::.|..:...  .|.||.   
Mouse  1157 SAGVFQRQPSCATFS-SNQSDNGL---DSDDDQPVEGVITNGSRVEVEVDIHCCRGREPESSPPL 1217

  Fly   758 ---SESVLSEEQFK-----------------------CWEYMLEQNTQLLFDKELNTISKSFTKQ 796
               |.:..|||:.:                       ..|.....:|..|:.|:|:..|      
Mouse  1218 PKNSSNACSEERARGAGFGIRRQNSVNSGILLPANRDKMELQKSPSTSCLYGKKLSNGS------ 1276

  Fly   797 RTVP-----NAIMAATVLPERND--FTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSYHQVKQA 854
             .||     |.|..||..|:|..  |.:.......::|:      :|:.:...|.    .|:||.
Mouse  1277 -IVPLEDSLNLIEVATEAPKRKTGYFAAPTQLEPEDQFV------VPRDLEEEVK----EQMKQH 1330

  Fly   855 PPG 857
            ..|
Mouse  1331 QEG 1333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 10/18 (56%)
LRR_8 109..169 CDD:290566 18/59 (31%)
leucine-rich repeat 111..135 CDD:275380 9/23 (39%)
leucine-rich repeat 136..158 CDD:275380 5/21 (24%)
leucine-rich repeat 159..183 CDD:275380 8/23 (35%)
leucine-rich repeat 184..209 CDD:275380 5/27 (19%)
LRR_8 205..266 CDD:290566 20/62 (32%)
leucine-rich repeat 210..230 CDD:275380 8/19 (42%)
leucine-rich repeat 232..255 CDD:275380 8/24 (33%)
LRR_RI <256..410 CDD:238064 46/153 (30%)
leucine-rich repeat 256..276 CDD:275380 7/19 (37%)
LRR_8 279..359 CDD:290566 29/79 (37%)
leucine-rich repeat 280..303 CDD:275380 10/22 (45%)
leucine-rich repeat 304..348 CDD:275380 15/43 (35%)
leucine-rich repeat 349..372 CDD:275380 6/22 (27%)
PP2Cc 461..655 CDD:294085 60/237 (25%)
Phlpp2NP_001116066.2 PH_PHLPP-like 181..275 CDD:270131
leucine-rich repeat 285..305 CDD:275380
leucine-rich repeat 306..332 CDD:275380
LRR_RI 309..548 CDD:238064 48/193 (25%)
LRR_8 354..412 CDD:290566 11/53 (21%)
leucine-rich repeat 356..378 CDD:275380 6/19 (32%)
leucine-rich repeat 379..401 CDD:275380 3/21 (14%)
leucine-rich repeat 402..424 CDD:275380 1/21 (5%)
LRR_8 425..483 CDD:290566 8/58 (14%)
leucine-rich repeat 425..448 CDD:275380 4/22 (18%)
LRR_RI 447..714 CDD:238064 88/277 (32%)
leucine-rich repeat 449..472 CDD:275380 2/23 (9%)
leucine-rich repeat 474..493 CDD:275380 8/18 (44%)
leucine-rich repeat 494..513 CDD:275380 10/18 (56%)
leucine-rich repeat 514..535 CDD:275380 9/23 (39%)
LRR_8 536..592 CDD:290566 16/60 (27%)
leucine-rich repeat 536..558 CDD:275380 5/21 (24%)
leucine-rich repeat 559..581 CDD:275380 8/26 (31%)
leucine-rich repeat 582..597 CDD:275380 3/14 (21%)
LRR_8 604..664 CDD:290566 20/60 (33%)
leucine-rich repeat 604..627 CDD:275380 8/23 (35%)
leucine-rich repeat 628..653 CDD:275380 8/24 (33%)
leucine-rich repeat 654..677 CDD:275380 7/22 (32%)
LRR_8 676..735 CDD:290566 23/58 (40%)
leucine-rich repeat 678..701 CDD:275380 10/22 (45%)
leucine-rich repeat 702..724 CDD:275380 10/21 (48%)
leucine-rich repeat 747..768 CDD:275380 5/20 (25%)
PP2Cc 816..1065 CDD:238083 69/265 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172467at2759
OrthoFinder 1 1.000 - - FOG0003647
OrthoInspector 1 1.000 - - otm43529
orthoMCL 1 0.900 - - OOG6_102913
Panther 1 1.100 - - O PTHR45752
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9772
SonicParanoid 1 1.000 - - X32
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.810

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