DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Lrrc4c

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001276671.1 Gene:Lrrc4c / 241568 MGIID:2442636 Length:640 Species:Mus musculus


Alignment Length:321 Identity:81/321 - (25%)
Similarity:131/321 - (40%) Gaps:90/321 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 LEVCENEMEVLDLSS---LAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVPL 134
            |.:.||:::::.::|   |..||.|:.|||.:..:.|..         .|.|.|::|        
Mouse    81 LNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGA---------FNGLANLNT-------- 128

  Fly   135 KLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAVLLRNY---RITELVSLDLAYNDLKQ 196
                :::..|..:.:||  ||...|:.:.....| ||....:.:|   ||..|..|||  .:||:
Mouse   129 ----LELFDNRLTTIPN--GAFVYLSKLKELWLR-NNPIESIPSYAFNRIPSLRRLDL--GELKR 184

  Fly   197 LDQFP----EGFSSIRSLQL---QSNELPSL--------------------PDNFFAVTHARLET 234
            |....    ||.|::|.|.|   ...|:|:|                    |.:|..:.|  |:.
Mouse   185 LSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMH--LQK 247

  Fly   235 LNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLN---DSIFEPLHNAAKLRVLHLAYNRIGVLPAA 296
            |.:..:::..:.|...:|..:||.::||.|:|.   ..:|.|||:   |..:||.:|     |..
Mouse   248 LWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHH---LERIHLHHN-----PWN 304

  Fly   297 CVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLC-TPQLAKLAMLKVLDLSH 356
            |     ..:||.||..:....|...|         ||..   | ||...|...:..||.::
Mouse   305 C-----NCDILWLSWWIRDMAPSNTA---------CCAR---CNTPPNLKGRYIGELDQNY 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 7/18 (39%)
LRR_8 109..169 CDD:290566 10/59 (17%)
leucine-rich repeat 111..135 CDD:275380 4/23 (17%)
leucine-rich repeat 136..158 CDD:275380 5/21 (24%)
leucine-rich repeat 159..183 CDD:275380 7/26 (27%)
leucine-rich repeat 184..209 CDD:275380 10/28 (36%)
LRR_8 205..266 CDD:290566 19/83 (23%)
leucine-rich repeat 210..230 CDD:275380 7/42 (17%)
leucine-rich repeat 232..255 CDD:275380 4/22 (18%)
LRR_RI <256..410 CDD:238064 30/105 (29%)
leucine-rich repeat 256..276 CDD:275380 9/22 (41%)
LRR_8 279..359 CDD:290566 20/79 (25%)
leucine-rich repeat 280..303 CDD:275380 6/22 (27%)
leucine-rich repeat 304..348 CDD:275380 12/44 (27%)
leucine-rich repeat 349..372 CDD:275380 2/8 (25%)
PP2Cc 461..655 CDD:294085
Lrrc4cNP_001276671.1 LRRNT 47..80 CDD:214470
PPP1R42 65..235 CDD:411060 44/179 (25%)
LRR 1 77..98 4/16 (25%)
leucine-rich repeat 78..101 CDD:275380 5/19 (26%)
LRR 2 101..122 7/29 (24%)
leucine-rich repeat 102..125 CDD:275380 9/31 (29%)
LRR 3 125..146 7/34 (21%)
leucine-rich repeat 126..149 CDD:275380 7/36 (19%)
LRR 4 149..170 4/21 (19%)
leucine-rich repeat 150..173 CDD:275380 6/23 (26%)
LRR 5 173..195 7/23 (30%)
leucine-rich repeat 174..198 CDD:275380 9/25 (36%)
LRR 6 198..219 6/20 (30%)
leucine-rich repeat 199..220 CDD:275380 6/20 (30%)
LRR_8 220..279 CDD:404697 12/60 (20%)
LRR 7 220..241 2/20 (10%)
leucine-rich repeat 221..244 CDD:275380 2/22 (9%)
LRR 8 244..265 4/22 (18%)
leucine-rich repeat 245..268 CDD:275380 4/22 (18%)
LRR_8 267..>301 CDD:404697 13/36 (36%)
LRR 9 268..289 7/20 (35%)
leucine-rich repeat 269..290 CDD:275380 7/20 (35%)
LRRCT 301..>339 CDD:214507 15/59 (25%)
IG 360..443 CDD:214652
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 463..482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X32
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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