DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Gucy1b2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_011243363.2	Gene:	Gucy1b2 / 239134	MGIID:	2660873	Length:	829	Species:	Mus musculus

Alignment Length:	178	Identity:	37/178 - (20%)
Similarity:	67/178 - (37%)	Gaps:	65/178 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 DNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLA 286
            |.:|::.|.:: |.|:|                              ||.:.:::...|:
Mouse   420 DEYFSIVHPQV-TFNIS------------------------------SICKFINSQFILK----- 448

  Fly   287 YNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVLRCCNNLLLCTPQLAKLAMLKV 351
             .|..::|.|    |.....|.|.|.|:           .:..|:|.  :.:|:|   ||..|:.
Mouse   449 -TRREMMPEA----WKSQPTLKLRGQMI-----------WMESLKCM--VFMCSP---KLRSLQE 492

  Fly   352 LDLSHNHL------DRVNLLALVPSRNLKYLDLSGNLQLQVDEQQFKV 393
            |:.|..||      |....|.|:..:.|..::||  .||:..:::.:|
Mouse   493 LEESKMHLSDIAPHDTTRDLILLNQQRLAEMELS--CQLEKKKEELRV 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380
		LRR_8	109..169	CDD:290566
		leucine-rich repeat	111..135	CDD:275380
		leucine-rich repeat	136..158	CDD:275380
		leucine-rich repeat	159..183	CDD:275380
		leucine-rich repeat	184..209	CDD:275380
		LRR_8	205..266	CDD:290566	6/43 (14%)
		leucine-rich repeat	210..230	CDD:275380	2/7 (29%)
		leucine-rich repeat	232..255	CDD:275380	3/22 (14%)
		LRR_RI	<256..410	CDD:238064	31/144 (22%)
		leucine-rich repeat	256..276	CDD:275380	2/19 (11%)
		LRR_8	279..359	CDD:290566	18/79 (23%)
		leucine-rich repeat	280..303	CDD:275380	5/22 (23%)
		leucine-rich repeat	304..348	CDD:275380	10/43 (23%)
		leucine-rich repeat	349..372	CDD:275380	8/28 (29%)
		PP2Cc	461..655	CDD:294085
Gucy1b2	XP_011243363.2	HNOB	115..276	CDD:400167
		HNOBA	380..566	CDD:400168	37/178 (21%)
		Guanylate_cyc	572..754	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900