DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and Lrfn5

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_848829.2	Gene:	Lrfn5 / 238205	MGIID:	2144814	Length:	746	Species:	Mus musculus

Alignment Length:	349	Identity:	83/349 - (23%)
Similarity:	133/349 - (38%)	Gaps:	109/349 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMEL--IINGTNLQTLVADHNYLHNIS 125
            |||   ...:.::|........||  ..|.|| |::..|:.:  .|:...::..:|| |::.||.
Mouse    10 LIG---IAVRAQICPKRCVCQILS--PNLATL-CAKKGLLFVPPNIDRRTVELRLAD-NFVTNIK 67

  Fly   126 TTN----THPVPLKLQRIDISH---NNFSELPNWVGACASLTAINASHNRLNNVA---------- 173
            ..:    |..|.|.|.|..||.   :.|::|.|       |.|::.:.|||..:.
Mouse    68 RKDFANMTSLVDLTLSRNTISFITPHAFADLRN-------LRALHLNSNRLTKITNDMFSGLSNL 125

  Fly   174 --VLLRNYRIT-----------ELVSLDLAYNDLKQLD-QFPEGFSSIRSLQLQSNELPSLPDNF 224
              ::|.|.::|           .|..|||:||:|:.:. ...|...|:.:|.|..|.:.::|...
Mouse   126 HHLILNNNQLTLISSTAFDDVFALEELDLSYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGT 190

  Fly   225 FAVTHARLETLNVSCNKLSTLP------RYEQNNHAALVN-----LSLAGNHLNDSIFEPLH-NA 277
            |:..| ::..|:|:.|||..||      |.:....:.:::     ||..||        ||| |.
Mouse   191 FSHLH-KMTRLDVTSNKLQKLPPDPLFQRAQVLATSGIISPSTFALSFGGN--------PLHCNC 246

  Fly   278 AKLRVLHLAYNRIGVLPAACVRNWPELEI----LVLSGNMLQQLPEEVATLGQLRVLRCCNNLLL 338
            ..|.:..|:..             .:||.    .:|:|.....:|||.               .|
Mouse   247 ELLWLRRLSRE-------------DDLETCASPALLTGRYFWSIPEEE---------------FL 283

  Fly   339 CTPQLAKLAMLKVLDLSHNHLDRV 362
            |.|.|.         ..|.|..||
Mouse   284 CEPPLI---------TRHTHEMRV 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	6/20 (30%)
		LRR_8	109..169	CDD:290566	18/66 (27%)
		leucine-rich repeat	111..135	CDD:275380	7/27 (26%)
		leucine-rich repeat	136..158	CDD:275380	7/24 (29%)
		leucine-rich repeat	159..183	CDD:275380	8/46 (17%)
		leucine-rich repeat	184..209	CDD:275380	9/25 (36%)
		LRR_8	205..266	CDD:290566	19/71 (27%)
		leucine-rich repeat	210..230	CDD:275380	5/19 (26%)
		leucine-rich repeat	232..255	CDD:275380	8/28 (29%)
		LRR_RI	<256..410	CDD:238064	25/117 (21%)
		leucine-rich repeat	256..276	CDD:275380	7/25 (28%)
		LRR_8	279..359	CDD:290566	14/83 (17%)
		leucine-rich repeat	280..303	CDD:275380	2/22 (9%)
		leucine-rich repeat	304..348	CDD:275380	11/47 (23%)
		leucine-rich repeat	349..372	CDD:275380	4/14 (29%)
		PP2Cc	461..655	CDD:294085
Lrfn5	NP_848829.2	LRR 1	52..73		5/21 (24%)
		leucine-rich repeat	53..76	CDD:275380	5/23 (22%)
		LRR_8	55..111	CDD:338972	18/63 (29%)
		LRR 2	76..97		7/20 (35%)
		leucine-rich repeat	77..100	CDD:275380	8/22 (36%)
		LRR_8	100..159	CDD:338972	15/65 (23%)
		LRR 3	100..121		6/27 (22%)
		leucine-rich repeat	101..124	CDD:275380	5/22 (23%)
		LRR 4	124..145		3/20 (15%)
		leucine-rich repeat	125..148	CDD:275380	3/22 (14%)
		LRR 5	148..169		7/20 (35%)
		LRR_8	149..207	CDD:338972	18/58 (31%)
		leucine-rich repeat	149..172	CDD:275380	8/22 (36%)
		LRR 6	172..193		6/20 (30%)
		leucine-rich repeat	173..196	CDD:275380	6/23 (26%)
		LRR 7	196..217		7/20 (35%)
		leucine-rich repeat	197..215	CDD:275380	7/17 (41%)
		TPKR_C2	240..>272	CDD:387596	10/52 (19%)
		Ig_2	301..374	CDD:143241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..416
		fn3	421..493	CDD:365830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000