DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and PHLPP1

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	918	Identity:	225/918 - (24%)
Similarity:	372/918 - (40%)	Gaps:	188/918 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTTNTHPVP 133
            ::|||::.:|::..||......:|.|.|.||:|:.|.|.|..|:.|.|..|.|..:   :.:|||
Human   832 HVTQLDLRDNKLGDLDAMIFNNIEVLHCERNQLVTLDICGYFLKALYASSNELVQL---DVYPVP 893

  Fly   134 LKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNV-AVLLRNYRITELVSLDLAYNDLKQL 197
            ..|..:|:|.|....:|.||.....|..::..||::..: |.|..|..:.:|::   .:|   ||
Human   894 NYLSYMDVSRNRLENVPEWVCESRKLEVLDIGHNQICELPARLFCNSSLRKLLA---GHN---QL 952

  Fly   198 DQFPEGF--SSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLP--RYEQNNHAALVN 258
            .:.||..  :|:..|.:|.|:|..||.|......: |..||.|.|||.:||  ...:..::.|..
Human   953 ARLPERLERTSVEVLDVQHNQLLELPPNLLMKADS-LRFLNASANKLESLPPATLSEETNSILQE 1016

  Fly   259 LSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVAT 323
            |.|..|.|.|.....|.....|::||:||||:...||:.:....|||.:.||||.|:.:|..:..
Human  1017 LYLTNNSLTDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMN 1081

  Fly   324 LGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQLQVDE 388
            ..::..:...:|.:...|::.:|..:|.:|||.|.|..|.|...:|.: |:.|||:||.:|.:|.
Human  1082 CRRMHTVIAHSNCIEVFPEVMQLPEIKCVDLSCNELSEVTLPENLPPK-LQELDLTGNPRLVLDH 1145

  Fly   389 QQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGP---WTMGFAETPGSGDCR 450
            :..::.               ||   :...||.|.|.    ...||.   |:.|:.|  .||...
Human  1146 KTLELL---------------NN---IRCFKIDQPST----GDASGAPAVWSHGYTE--ASGVKN 1186

  Fly   451 KLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQ---EQMVKDSAVRDYMKFT 512
            ||.|..|...|:..:.|||||:|:     |....|:.:|:...|..   |::.|.....:||..|
Human  1187 KLCVAALSVNNFCDNREALYGVFD-----GDRNVEVPYLLQCTMSDILAEELQKTKNEEEYMVNT 1246

  Fly   513 LLAAQQQCGSV-----RSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQLRLT 572
            .:..|::.|:.     .:|.|.|:..    ..|.|..|  :.|..|:.|.....|.|....|.|:
Human  1247 FIVMQRKLGTAGQKLGGAAVLCHIKH----DPVDPGGS--FTLTSANVGKCQTVLCRNGKPLPLS 1305

  Fly   573 KPDVIQKDQ--------------------------------IHS--MPDPHVLELILSNDDEYLV 603
            :..::..::                                :|.  :|.|||..::|:..||:.:
Human  1306 RSYIMSCEEELKRIKQHKAIITEDGKVNGVTESTRILGYTFLHPSVVPRPHVQSVLLTPQDEFFI 1370

  Fly   604 VGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFR------------ 656
            :|:..||..:.::.|...:|...::|.|||:|..:|||:...:|:|.:||:..
Human  1371 LGSKGLWDSLSVEEAVEAVRNVPDALAAAKKLCTLAQSYGCHDSISAVVVQLSVTEDSFCCCELS 1435

  Fly   657 ---------------------------HLGT---------------DVDHLIRELKQSVRKKPQP 679
                                       .||.               ....:..|:..:...:|.|
Human  1436 AGGAVPPPSPGIFPPSVNMVIKDRPSDGLGVPSSSSGMASEISSELSTSEMSSEVGSTASDEPPP 1500

  Fly   680 VSLPLSSGSVCKRTCCDRSNACRHRAIEQEPLAGRSSPSGQSDRDLLAKDKDDE----------- 733
            .:|..:|.:......|.....|...:.::: |:..:..|..||..|   |.|||
Human  1501 GALSENSPAYPSEQRCMLHPICLSNSFQRQ-LSSATFSSAFSDNGL---DSDDEEPIEGVFTNGS 1561

  Fly   734 ----FVLAH-ARVLQEEQQLEMLDETESVSES--VLSEEQFKCWEYMLEQNTQLLFDKELNTISK 791
                .|..| :|..::|:|..:|......|:.  |:|..:.   |..|.:....   ..:.||.:
Human  1562 RVEVEVDIHCSRAKEKEKQQHLLQVPAEASDEGIVISANED---EPGLPRKADF---SAVGTIGR 1620

  Fly   792 -----SFTKQRTVPNAIMAATVLPERND---FTSNLMRTVTNKFISTSTPQLPQPITTSVPLGSY 848
                 |...|....|.|..||..|.|..   |.:.......::||  ..|:|.:.:...:.....
Human  1621 RRANGSVAPQERSHNVIEVATDAPLRKPGGYFAAPAQPDPDDQFI--IPPELEEEVKEIMKHHQE 1683

  Fly   849 HQVKQAPP 856
            .|.:|.||
Human  1684 QQQQQQPP 1691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	9/18 (50%)
		LRR_8	109..169	CDD:290566	18/59 (31%)
		leucine-rich repeat	111..135	CDD:275380	8/23 (35%)
		leucine-rich repeat	136..158	CDD:275380	7/21 (33%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	7/26 (27%)
		LRR_8	205..266	CDD:290566	21/62 (34%)
		leucine-rich repeat	210..230	CDD:275380	7/19 (37%)
		leucine-rich repeat	232..255	CDD:275380	9/24 (38%)
		LRR_RI	<256..410	CDD:238064	45/153 (29%)
		leucine-rich repeat	256..276	CDD:275380	7/19 (37%)
		LRR_8	279..359	CDD:290566	26/79 (33%)
		leucine-rich repeat	280..303	CDD:275380	9/22 (41%)
		leucine-rich repeat	304..348	CDD:275380	11/43 (26%)
		leucine-rich repeat	349..372	CDD:275380	9/22 (41%)
		PP2Cc	461..655	CDD:294085	56/235 (24%)
PHLPP1	NP_919431.2	leucine-rich repeat	1107..1129	CDD:275380	9/21 (43%)
		PP2Cc	1168..1420	CDD:214625	65/264 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1510		7/51 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1673..1717		4/19 (21%)
		PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1715..1717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..470
		PH_PHLPP-like	535..631	CDD:270131
		PH	555..636	CDD:278594
		LRR_RI	625..929	CDD:238064	33/99 (33%)
		LRR_8	638..703	CDD:290566
		LRR 1	638..659
		leucine-rich repeat	641..661	CDD:275380
		LRR 2	661..682
		leucine-rich repeat	662..692	CDD:275380
		LRR 3	692..712
		leucine-rich repeat	693..738	CDD:275380
		LRR_8	714..770	CDD:290566
		LRR 4	715..736
		LRR 5	738..760
		leucine-rich repeat	739..761	CDD:275380
		LRR 6	761..783
		leucine-rich repeat	762..784	CDD:275380
		LRR 7	784..804
		leucine-rich repeat	785..808	CDD:275380
		LRR 8	808..831
		leucine-rich repeat	810..832	CDD:275380	225/918 (25%)
		LRR_RI	814..1074	CDD:238064	83/251 (33%)
		LRR 9	832..853		6/20 (30%)
		leucine-rich repeat	833..853	CDD:275380	6/19 (32%)
		leucine-rich repeat	854..895	CDD:275380	17/43 (40%)
		LRR 10	873..894		7/23 (30%)
		LRR 11	895..916		7/20 (35%)
		leucine-rich repeat	896..918	CDD:275380	7/21 (33%)
		LRR 12	918..939		5/20 (25%)
		leucine-rich repeat	919..941	CDD:275380	6/21 (29%)
		LRR 13	941..962		6/26 (23%)
		leucine-rich repeat	942..963	CDD:275380	6/26 (23%)
		LRR_8	962..1024	CDD:290566	21/62 (34%)
		LRR 14	963..984		8/20 (40%)
		leucine-rich repeat	964..987	CDD:275380	7/22 (32%)
		LRR 15	987..1008		9/21 (43%)
		leucine-rich repeat	988..1011	CDD:275380	9/22 (41%)
		LRR 16	1013..1033		6/19 (32%)
		LRR_8	1014..1072	CDD:290566	23/57 (40%)
		leucine-rich repeat	1014..1037	CDD:275380	7/22 (32%)
		LRR 17	1037..1058		9/20 (45%)
		leucine-rich repeat	1038..1061	CDD:275380	9/22 (41%)
		LRR 18	1061..1082		9/20 (45%)
		Interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1076..1205		40/153 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	72	1.000	Domainoid score	I9414
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5072
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172467at2759
OrthoFinder	1	1.000	-	-		FOG0003647
OrthoInspector	1	1.000	-	-		otm41480
orthoMCL	1	0.900	-	-		OOG6_102913
Panther	1	1.100	-	-	O	PTHR45752
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760