DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phlpp and FLII

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	XP_005256612.1	Gene:	FLII / 2314	HGNCID:	3750	Length:	1296	Species:	Homo sapiens

Alignment Length:	553	Identity:	128/553 - (23%)
Similarity:	208/553 - (37%)	Gaps:	167/553 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LSLKGSQLGGSILIGNYNYLTQLEVCENEMEVL-----DLSSLAQLETLKCSRNKLMEL---IIN 107
            :.|.|:...|.....|...:|.|...:.....|     :|::|.:||.|..|.|.|..|   :.:
Human    13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSS 77

  Fly   108 GTNLQTLVADHNYLHNISTTNTHPVP---LKLQR---IDISHNNFSELPNWVGACASLTAINASH 166
            ..:|:.:||..|.|.|..      ||   .||..   :|:|||..:|.|..:....::..:|.||
Human    78 LPSLRAIVARANSLKNSG------VPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSH 136

  Fly   167 NRLNNVAVLLRNYRITELVSLDLAYNDLK-------------------------QLDQFPEGFSS 206
            |.::.:...| ...:|:|:.|||:.|.|:                         ||.|.| ..::
Human   137 NSIDTIPNQL-FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLP-AMTA 199

  Fly   207 IRSLQLQSNE--LPSLPDNFFAVTHARLETLNVSCNKLSTLPRYEQNNHAALVNLSLAGNHLNDS 269
            :::|.|:|.:  ..:||.:...:::  |..:::|||.|:.:|
Human   200 LQTLHLRSTQRTQSNLPTSLEGLSN--LADVDLSCNDLTRVP----------------------- 239

  Fly   270 IFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPEEVATLGQLRVL---- 330
              |.|:....||.|:|:.|:|..| :.|:..|..:|.|.||.|.|..||..:..|.:|:.|
Human   240 --ECLYTLPSLRRLNLSSNQITEL-SLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNS 301

  Fly   331 ----------------------RCCNNLLLCTPQLAKLAMLKVLDLSHNHL----DRVNLLALVP 369
                                  ...|||.|....|.:...|:.|.|:.|||    :.::.|.
Human   302 NKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLT--- 363

  Fly   370 SRNLKYLDLSGNLQLQVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSG 434
              .::.||:..|..|.:..:     .:.....|..:|.|                 .:||.:.:|
Human   364 --EIEVLDVRENPNLVMPPK-----PADRAAEWYNIDFS-----------------LQNQLRLAG 404

  Fly   435 --PWTMGFAETPGSGD----CRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDL 493
              |.|:..|...|||.    .||:   :||.......|:...   :.|:|....|||.:
Human   405 ASPATVAAAAAAGSGPKDPMARKM---RLRRRKDSAQDDQAK---QVLKGMSDVAQEKN------ 457

  Fly   494 MKQEQMVKDSA----VR-----------DYMKF 511
            .|||:.....|    ||           ||.:|
Human   458 KKQEESADARAPSGKVRRWDQGLEKPRLDYSEF 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	7/21 (33%)
		LRR_8	109..169	CDD:290566	20/65 (31%)
		leucine-rich repeat	111..135	CDD:275380	8/26 (31%)
		leucine-rich repeat	136..158	CDD:275380	7/24 (29%)
		leucine-rich repeat	159..183	CDD:275380	5/23 (22%)
		leucine-rich repeat	184..209	CDD:275380	10/49 (20%)
		LRR_8	205..266	CDD:290566	11/62 (18%)
		leucine-rich repeat	210..230	CDD:275380	5/21 (24%)
		leucine-rich repeat	232..255	CDD:275380	6/22 (27%)
		LRR_RI	<256..410	CDD:238064	41/183 (22%)
		leucine-rich repeat	256..276	CDD:275380	2/19 (11%)
		LRR_8	279..359	CDD:290566	29/105 (28%)
		leucine-rich repeat	280..303	CDD:275380	9/22 (41%)
		leucine-rich repeat	304..348	CDD:275380	16/69 (23%)
		leucine-rich repeat	349..372	CDD:275380	7/26 (27%)
		PP2Cc	461..655	CDD:294085	15/66 (23%)
FLII	XP_005256612.1	LRR_RI	<2..139	CDD:238064	36/131 (27%)
		leucine-rich repeat	10..34	CDD:275380	4/20 (20%)
		LRR_8	33..91	CDD:290566	16/57 (28%)
		leucine-rich repeat	35..57	CDD:275380	4/21 (19%)
		leucine-rich repeat	58..80	CDD:275380	7/21 (33%)
		leucine-rich repeat	83..105	CDD:275378	9/27 (33%)
		LRR_RI	89..374	CDD:238064	76/325 (23%)
		leucine-rich repeat	106..128	CDD:275380	6/21 (29%)
		leucine-rich repeat	129..152	CDD:275380	5/23 (22%)
		LRR_8	131..186	CDD:290566	12/55 (22%)
		leucine-rich repeat	153..175	CDD:275380	6/21 (29%)
		leucine-rich repeat	176..199	CDD:275380	4/23 (17%)
		leucine-rich repeat	200..224	CDD:275380	5/23 (22%)
		LRR_8	223..281	CDD:290566	22/85 (26%)
		leucine-rich repeat	225..247	CDD:275380	8/46 (17%)
		leucine-rich repeat	248..270	CDD:275380	9/22 (41%)
		leucine-rich repeat	271..293	CDD:275380	9/21 (43%)
		leucine-rich repeat	294..318	CDD:275380	2/23 (9%)
		leucine-rich repeat	319..339	CDD:275380	5/19 (26%)
		leucine-rich repeat	342..355	CDD:275378	6/12 (50%)
		gelsolin_S1_like	492..604	CDD:200446
		gelsolin_like	619..706	CDD:200436
		gelsolin_S3_like	723..837	CDD:200448
		gelsolin_like	<974..1034	CDD:200436
		gelsolin_S5_like	1053..1152	CDD:200444
		gelsolin_S6_like	1163..1289	CDD:200447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910