DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phlpp and PHLPP2

DIOPT Version :9

Sequence 1:	NP_001260558.1	Gene:	Phlpp / 35178	FlyBaseID:	FBgn0032749	Length:	954	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	954	Identity:	243/954 - (25%)
Similarity:	393/954 - (41%)	Gaps:	218/954 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LIGNYNYLTQLEVCENEMEVLDLSSLAQLETLKCSRNKLMELIINGTNLQTLVADHNYLHNISTT 127
            |.|| .::|.:::.:|.:..||||||..||.|.|.||:|.||.::|.:|:||.|..|   .::..
Human   435 LEGN-KHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTLSGFSLRTLYASSN---RLTAV 495

  Fly   128 NTHPVPLKLQRIDISHNNFSELPNWVGACASLTAINASHNRLNNVAV-LLRNYRITELVSLDLAY 191
            |.:|||..|..:|:|.|....:|:|......:..::.|:|.|..|.| :|.:..:.:|:   |.:
Human   496 NVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLM---LGH 557

  Fly   192 NDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHARLETLNVSCNKLSTLPR--YEQNNHA 254
            |.::.|....|.. .:..|.||.|.|..|||..|:.. ..|..||.|.|.|.:||.  ..:.:.:
Human   558 NHVQNLPTLVEHI-PLEVLDLQHNALTRLPDTLFSKA-LNLRYLNASANSLESLPSACTGEESLS 620

  Fly   255 ALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQLPE 319
            .|..|.|..|.|.|.....|.....||:||||.|::...||:.:....:||.|.||||.|:.:|.
Human   621 MLQLLYLTNNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPT 685

  Fly   320 EVATLGQLRVLRCCNNLLLCTPQLAKLAMLKVLDLSHNHLDRVNLLALVPSRNLKYLDLSGNLQL 384
            .:|...:|..|...:|.:...|::.:|..::.:|||.|.|..:.:...:|: .|:.|||:||..|
Human   686 TIANCKRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPA-TLQDLDLTGNTNL 749

  Fly   385 QVDEQQFKVCQSQSQRHWSLVDVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGFAETPGSGDC 449
            .::.:...:        :|.:.....::..||||         :...||..|:.|.||.  :|..
Human   750 VLEHKTLDI--------FSHITTLKIDQKPLPTT---------DSTVTSTFWSHGLAEM--AGQR 795

  Fly   450 RKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHL----VPDLMKQE--QMVKDSAVRDY 508
            .||.|..|...::.....|:||||:     |...:|:..|    :.|::.:|  |...|:.   :
Human   796 NKLCVSALAMDSFAEGVGAVYGMFD-----GDRNEELPRLLQCTMADVLLEEVQQSTNDTV---F 852

  Fly   509 MKFTLLAAQQQCG----SVRSAALFHLTRTRAPSKVRPLKSKRYVLRMASTGGLDAYLIRRTSQL 569
            |..|.|.:.::.|    .:.|:||....|   |....|..|  :.|.:|:.|...|.|.|....:
Human   853 MANTFLVSHRKLGMAGQKLGSSALLCYIR---PDTADPASS--FSLTVANVGTCQAVLCRGGKPV 912

  Fly   570 RLTK-------PDVIQ--KDQ---------IHS-----------------MPDPHVLELILSNDD 599
            .|:|       |:..|  |||         ::.                 :|.||:....|:..|
Human   913 PLSKVFSLEQDPEEAQRVKDQKAIITEDNKVNGVTCCTRMLGCTYLYPWILPKPHISSTPLTIQD 977

  Fly   600 EYLVVGNAQLWSVMDIDRAAREIRKEENSLLAAKRLVDIAQSFAAAESLSVIVVRFRHLGTDVDH 664
            |.|::||..||..:....|...:|..::.|.|||:|..:|||:...:::..:||   :|....:.
Human   978 ELLILGNKALWEHLSYTEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVV---YLNIGEEG 1039

  Fly   665 LIRELK-------------QSVRKKPQPVSLPLSSG---------------SVCKRTCCDRSNAC 701
            ...|:.             .:::..|:|.:...|||               |....|..|..||.
Human  1040 CTCEMNGLTLPGPVGFASTTTIKDAPKPATPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNAG 1104

  Fly   702 -----------RHRAIEQEPLAG--RSSP------SGQSDRDLLAKDKDD----EFVLAHARVLQ 743
                       |..::...|.:|  :..|      |.|||..|   |.||    |.|:.:...::
Human  1105 GLDTALLPRPERRCSLHPTPTSGLFQRQPSSATFSSNQSDNGL---DSDDDQPVEGVITNGSKVE 1166

  Fly   744 EEQQLEM-----LDETESVSES---VLSEEQFK--CW---------------------EYMLEQN 777
            .|..:..     |:.:..:.||   :.|||..:  |:                     |.....:
Human  1167 VEVDIHCCRGRDLENSPPLIESSPTLCSEEHARGSCFGIRRQNSVNSGMLLPMSKDRMELQKSPS 1231

  Fly   778 TQLLFDKELNTISKSFTKQRTVP-----NAIMAATVLPERND--FTSNLMRTVTNKFISTSTPQL 835
            |..|:.|:|:..|       .||     |.|..||.:|:|..  |.:.......::|:      :
Human  1232 TSCLYGKKLSNGS-------IVPLEDSLNLIEVATEVPKRKTGYFAAPTQMEPEDQFV------V 1283

  Fly   836 PQPITTSVPLGSYHQVKQ----------------APPGHFGSAL 863
            |..:...|.    .|:||                .||..|.:||
Human  1284 PHDLEEEVK----EQMKQHQDSRLEPEPHEEDRTEPPEEFDTAL 1323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phlpp	NP_001260558.1	leucine-rich repeat	91..110	CDD:275380	10/18 (56%)
		LRR_8	109..169	CDD:290566	17/59 (29%)
		leucine-rich repeat	111..135	CDD:275380	9/23 (39%)
		leucine-rich repeat	136..158	CDD:275380	6/21 (29%)
		leucine-rich repeat	159..183	CDD:275380	6/24 (25%)
		leucine-rich repeat	184..209	CDD:275380	5/24 (21%)
		LRR_8	205..266	CDD:290566	21/62 (34%)
		leucine-rich repeat	210..230	CDD:275380	9/19 (47%)
		leucine-rich repeat	232..255	CDD:275380	8/24 (33%)
		LRR_RI	<256..410	CDD:238064	45/153 (29%)
		leucine-rich repeat	256..276	CDD:275380	7/19 (37%)
		LRR_8	279..359	CDD:290566	28/79 (35%)
		leucine-rich repeat	280..303	CDD:275380	9/22 (41%)
		leucine-rich repeat	304..348	CDD:275380	15/43 (35%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		PP2Cc	461..655	CDD:294085	59/238 (25%)
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131
		LRR 1	250..271
		leucine-rich repeat	253..273	CDD:275380
		LRR 2	273..296
		leucine-rich repeat	274..300	CDD:275380
		LRR 3	300..321
		leucine-rich repeat	301..323	CDD:275380
		LRR_RI	313..606	CDD:238064	61/179 (34%)
		LRR_8	322..380	CDD:290566
		LRR 4	323..344
		leucine-rich repeat	324..346	CDD:275380
		LRR 5	346..368
		leucine-rich repeat	347..369	CDD:275380
		LRR 6	369..390
		leucine-rich repeat	370..416	CDD:275380
		LRR 7	392..412
		LRR 8	416..439		3/4 (75%)
		leucine-rich repeat	418..440	CDD:275380	3/5 (60%)
		LRR 9	440..460		7/19 (37%)
		leucine-rich repeat	442..461	CDD:275380	8/18 (44%)
		LRR 10	461..480		9/18 (50%)
		leucine-rich repeat	462..481	CDD:275380	10/18 (56%)
		LRR 11	481..502		8/23 (35%)
		leucine-rich repeat	482..503	CDD:275380	9/23 (39%)
		LRR 12	503..524		6/20 (30%)
		leucine-rich repeat	504..526	CDD:275380	6/21 (29%)
		LRR 13	526..547		6/20 (30%)
		leucine-rich repeat	527..549	CDD:275380	6/21 (29%)
		LRR_8	549..606	CDD:290566	19/61 (31%)
		LRR 14	549..570		5/23 (22%)
		leucine-rich repeat	550..565	CDD:275380	4/17 (24%)
		LRR 15	571..592		9/20 (45%)
		leucine-rich repeat	572..595	CDD:275380	9/23 (39%)
		LRR 16	595..616		8/20 (40%)
		leucine-rich repeat	596..645	CDD:275380	15/48 (31%)
		LRR 17	621..644		7/22 (32%)
		LRR_8	645..703	CDD:290566	22/57 (39%)
		LRR_4	645..685	CDD:289563	17/39 (44%)
		LRR 18	645..666		9/20 (45%)
		leucine-rich repeat	646..669	CDD:275380	9/22 (41%)
		LRR 19	669..690		10/20 (50%)
		leucine-rich repeat	670..692	CDD:275380	10/21 (48%)
		LRR 20	692..713		4/20 (20%)
		leucine-rich repeat	693..714	CDD:275380	5/20 (25%)
		LRR 21	714..735		5/20 (25%)
		leucine-rich repeat	715..734	CDD:275380	5/18 (28%)
		LRR 22	737..758		7/20 (35%)
		leucine-rich repeat	738..764	CDD:275380	8/33 (24%)
		PP2Cc	784..1033	CDD:238083	68/266 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157		22/99 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323		7/41 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172467at2759
OrthoFinder	1	1.000	-	-		FOG0003647
OrthoInspector	1	1.000	-	-		otm41480
orthoMCL	1	0.900	-	-		OOG6_102913
Panther	1	1.100	-	-	O	PTHR45752
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9772
SonicParanoid	1	1.000	-	-		X32
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.810