DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Npr2

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_776149.1 Gene:Npr2 / 230103 MGIID:97372 Length:1047 Species:Mus musculus


Alignment Length:327 Identity:63/327 - (19%)
Similarity:106/327 - (32%) Gaps:110/327 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 KQADPYKSK--LKVSASHSGPHPLP-VEVTAAEEEQAATFGQTSPQKLSLKGSQLGGSILIGNYN 68
            ::||.|...  |:..|..|||..|. ::::..|..|....||....:.|:..:||       |..
Mouse   703 QKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQL-------NEE 760

  Fly    69 YLTQLEVC-----------------------ENEMEVLDLSSLAQLETLKCSRNKLMELIINGTN 110
            .:..:|.|                       |....:||              |.|:.:.....|
Mouse   761 LVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILD--------------NLLLRMEQYANN 811

  Fly   111 LQTLVADHN--YLHNISTTNT-------HPVPLKLQRID-ISHNNFSELPNWVGACASLTAINAS 165
            |:.||.:..  ||........       |.|..:|:|.: :....|..:..:.......||::|.
Mouse   812 LEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAE 876

  Fly   166 HNRLNNVAVLLRNYRITELVSLDLAYNDLKQLDQFPEGFSSIRSLQLQSNELPSLPDNFFAVTHA 230
            ...:..|.:|                |||...                   ..::.|||...   
Mouse   877 STPMQVVTLL----------------NDLYTC-------------------FDAIIDNFDVY--- 903

  Fly   231 RLETLNVSCNKLSTLPRYEQNNHA-ALVNLSLAGNHLNDSIFEPLHNAAKLRVLHLAYN----RI 290
            ::||:..:...:|.||......|| .:..::||   |.|::       :..|:.|..::    ||
Mouse   904 KVETIGDAYMVVSGLPGRNGQRHAPEIARMALA---LLDAV-------SSFRIRHRPHDQLRLRI 958

  Fly   291 GV 292
            ||
Mouse   959 GV 960

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 2/18 (11%)
LRR_8 109..169 CDD:290566 14/69 (20%)
leucine-rich repeat 111..135 CDD:275380 7/32 (22%)
leucine-rich repeat 136..158 CDD:275380 3/22 (14%)
leucine-rich repeat 159..183 CDD:275380 5/23 (22%)
leucine-rich repeat 184..209 CDD:275380 3/24 (13%)
LRR_8 205..266 CDD:290566 12/61 (20%)
leucine-rich repeat 210..230 CDD:275380 3/19 (16%)
leucine-rich repeat 232..255 CDD:275380 7/23 (30%)
LRR_RI <256..410 CDD:238064 10/41 (24%)
leucine-rich repeat 256..276 CDD:275380 4/19 (21%)
LRR_8 279..359 CDD:290566 6/18 (33%)
leucine-rich repeat 280..303 CDD:275380 6/17 (35%)
leucine-rich repeat 304..348 CDD:275380
leucine-rich repeat 349..372 CDD:275380
PP2Cc 461..655 CDD:294085
Npr2NP_776149.1 PBP1_NPR_B 26..421 CDD:380607
PK_GC-A_B 518..792 CDD:270944 19/95 (20%)
HNOBA <798..846 CDD:369471 12/61 (20%)
CYCc 825..1009 CDD:214485 33/184 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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