DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Lrfn4

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_700437.2 Gene:Lrfn4 / 225875 MGIID:2385612 Length:636 Species:Mus musculus


Alignment Length:236 Identity:58/236 - (24%)
Similarity:87/236 - (36%) Gaps:71/236 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 NYNYLTQLEVCENEMEVLDLSSLAQLETLK---CSRNKLMEL----IINGTNLQTLVADHNYLHN 123
            |...|..|.:..|.:..:...|...||:|:   ...|:|:||    :....|||.|:...|.|..
Mouse    70 NMTGLVDLTLSRNAITRIGARSFGDLESLRSLHLDGNRLVELGSSSLRGPVNLQHLILSGNQLGR 134

  Fly   124 ISTTNTHPVPLKLQRIDISHNNFSELPNW--VGACASLTAINASHNRLNNVAVLLRNYRITELVS 186
            |:..........|:.:|:|:||..::| |  :|:..:|..:|..||                   
Mouse   135 IAPGAFDDFLDSLEDLDVSYNNLRQVP-WAGIGSMPALHTLNLDHN------------------- 179

  Fly   187 LDLAYNDLKQLDQFPEG----FSSIRSLQLQSNELPSL-PDNFFAVTHARLETLNVSCNKLSTLP 246
                     .:|..|.|    .|.:..|.|.||.|.:| ||..|                  :..
Mouse   180 ---------LIDALPPGVFAQLSQLSRLDLTSNRLATLAPDPLF------------------SRG 217

  Fly   247 RYEQNNHAALVNLSLAGNHLNDSIFEPLH-NAAKLRVLHLA 286
            |..:.:.:.|| ||.:||        ||| |...|.:..||
Mouse   218 RDAEASPSPLV-LSFSGN--------PLHCNCELLWLRRLA 249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380 7/25 (28%)
LRR_8 109..169 CDD:290566 19/61 (31%)
leucine-rich repeat 111..135 CDD:275380 6/23 (26%)
leucine-rich repeat 136..158 CDD:275380 8/23 (35%)
leucine-rich repeat 159..183 CDD:275380 4/23 (17%)
leucine-rich repeat 184..209 CDD:275380 4/28 (14%)
LRR_8 205..266 CDD:290566 17/61 (28%)
leucine-rich repeat 210..230 CDD:275380 9/20 (45%)
leucine-rich repeat 232..255 CDD:275380 1/22 (5%)
LRR_RI <256..410 CDD:238064 13/32 (41%)
leucine-rich repeat 256..276 CDD:275380 9/20 (45%)
LRR_8 279..359 CDD:290566 3/8 (38%)
leucine-rich repeat 280..303 CDD:275380 3/7 (43%)
leucine-rich repeat 304..348 CDD:275380
leucine-rich repeat 349..372 CDD:275380
PP2Cc 461..655 CDD:294085
Lrfn4NP_700437.2 LRR 39..>205 CDD:227223 39/163 (24%)
LRR 1 49..70 58/236 (25%)
leucine-rich repeat 50..73 CDD:275380 1/2 (50%)
LRR 2 73..94 4/20 (20%)
leucine-rich repeat 74..97 CDD:275380 5/22 (23%)
LRR 3 97..118 5/20 (25%)
leucine-rich repeat 98..121 CDD:275380 5/22 (23%)
LRR 4 121..142 7/20 (35%)
leucine-rich repeat 122..146 CDD:275380 6/23 (26%)
LRR 5 146..169 8/23 (35%)
leucine-rich repeat 147..170 CDD:275380 8/23 (35%)
LRR 6 170..191 7/48 (15%)
leucine-rich repeat 171..194 CDD:275380 7/50 (14%)
LRR 7 194..215 9/38 (24%)
leucine-rich repeat 195..213 CDD:275380 8/17 (47%)
LRRCT 234..278 CDD:214507 8/24 (33%)
Ig 295..368 CDD:386229
fn3 409..478 CDD:365830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..585
PDZ-binding 633..636
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X32
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.000

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