DRSC/TRiP Functional Genomics Resources

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Protein Alignment Phlpp and Adcy5

DIOPT Version :9

Sequence 1:NP_001260558.1 Gene:Phlpp / 35178 FlyBaseID:FBgn0032749 Length:954 Species:Drosophila melanogaster
Sequence 2:NP_001012783.3 Gene:Adcy5 / 224129 MGIID:99673 Length:1262 Species:Mus musculus


Alignment Length:342 Identity:63/342 - (18%)
Similarity:127/342 - (37%) Gaps:70/342 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   218 PSLPDNFFAVTHARLET---LNVSCNKLSTLPRYEQNNHA----ALVNLSLAGNHLNDSIFEPLH 275
            |.|...:.||..|.:..   :.|.||:.:    :.|::..    ||:.:.||...:  .:..|..
Mouse   265 PPLQIAYLAVLAAAVGVILIMAVLCNRAA----FHQDHMGLACYALIAVVLAVQVV--GLLLPQP 323

  Fly   276 NAAKLRV---LHLAYNRIGVLPAACVRNWPELEILVLSGNMLQQL---------PEEVATLGQL- 327
            .:|...:   :...|....:||.       .:...||||.:|..|         .::...|.|| 
Mouse   324 RSASEGIWWTVFFIYTIYTLLPV-------RMRAAVLSGVLLSALHLAISLHTNSQDQFLLKQLV 381

  Fly   328 ---RVLRCCNNLLLCTPQLAKLAMLKVLDLSHN------HLDRVN------LLALVPSRNLKYLD 377
               .:..|.|.:.:||...|:::..:....:..      |..|.|      ||:::| |::. ::
Mouse   382 SNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLP-RHVA-ME 444

  Fly   378 LSGNLQLQVDEQQFKVCQSQSQRHWSLV--DVSGNNRAALPTTKIRQVSAQRNQNKTSGPWTMGF 440
            :..::..:.::..|.....|...:.|::  |:.|.      |:...|.:|| ....|.......|
Mouse   445 MKADINAKQEDMMFHKIYIQKHDNVSILFADIEGF------TSLASQCTAQ-ELVMTLNELFARF 502

  Fly   441 AETPGSGDCRKLSVYQLRAANYGGSDEALYGMFEALEGRGRAAQEMSHLVPDLMKQEQMVKD-SA 504
            .:......|.::.:       .|.....:.|:.||.........||.   .|:::...:|:: :.
Mouse   503 DKLAAENHCLRIKI-------LGDCYYCVSGLPEARADHAHCCVEMG---MDMIEAISLVREVTG 557

  Fly   505 VRDYMKFTLLAAQQQCG 521
            |...|:..:.:.:..||
Mouse   558 VNVNMRVGIHSGRVHCG 574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PhlppNP_001260558.1 leucine-rich repeat 91..110 CDD:275380
LRR_8 109..169 CDD:290566
leucine-rich repeat 111..135 CDD:275380
leucine-rich repeat 136..158 CDD:275380
leucine-rich repeat 159..183 CDD:275380
leucine-rich repeat 184..209 CDD:275380
LRR_8 205..266 CDD:290566 13/54 (24%)
leucine-rich repeat 210..230 CDD:275380 4/11 (36%)
leucine-rich repeat 232..255 CDD:275380 4/29 (14%)
LRR_RI <256..410 CDD:238064 33/183 (18%)
leucine-rich repeat 256..276 CDD:275380 4/19 (21%)
LRR_8 279..359 CDD:290566 17/101 (17%)
leucine-rich repeat 280..303 CDD:275380 3/25 (12%)
leucine-rich repeat 304..348 CDD:275380 14/56 (25%)
leucine-rich repeat 349..372 CDD:275380 6/34 (18%)
PP2Cc 461..655 CDD:294085 12/62 (19%)
Adcy5NP_001012783.3 AC_N 1..459 CDD:292831 39/208 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..194
CYCc 425..620 CDD:214485 29/169 (17%)
Guanylate_cyc 461..622 CDD:278633 23/131 (18%)
DUF1053 669..761 CDD:283888
CYCc 1037..1238 CDD:214485
Guanylate_cyc 1063..1257 CDD:278633
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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